메뉴 건너뛰기




Volumn 18, Issue 6, 2006, Pages 643-649

Genetics of autoimmune neuroinflammation

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN KINASE C ALPHA;

EID: 33750967383     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2006.08.001     Document Type: Review
Times cited : (20)

References (67)
  • 2
    • 23944499790 scopus 로고    scopus 로고
    • A high-density screen for linkage in multiple sclerosis
    • SNP-based typing, in the largest linkage analysis done to date, has failed to show any significant loci in non-HLA gene regions, suggesting low odds ratios of regulating genes, and that future genetics in MS will largely depend on association analysis in very large cohorts, either based on candidate genes or whole genome.
    • Sawcer S., Ban M., Maranian M., Yeo T.W., Compston A., Kirby A., Daly M.J., De Jager P.L., Walsh E., Lander E.S., et al. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet 77 (2005) 454-467. SNP-based typing, in the largest linkage analysis done to date, has failed to show any significant loci in non-HLA gene regions, suggesting low odds ratios of regulating genes, and that future genetics in MS will largely depend on association analysis in very large cohorts, either based on candidate genes or whole genome.
    • (2005) Am J Hum Genet , vol.77 , pp. 454-467
    • Sawcer, S.1    Ban, M.2    Maranian, M.3    Yeo, T.W.4    Compston, A.5    Kirby, A.6    Daly, M.J.7    De Jager, P.L.8    Walsh, E.9    Lander, E.S.10
  • 3
    • 33645775067 scopus 로고    scopus 로고
    • An utter refutation of the 'Fundamental Theorem of the HapMap'
    • This study critically assesses on theoretical grounds the potential of using a HapMap approach, with linkage disequilibrium as a requisite, to detect genes underlying complex diseases and gives examples on how relevant genes might go undetected with this approach.
    • Terwilliger J.D., and Hiekkalinna T. An utter refutation of the 'Fundamental Theorem of the HapMap'. Eur J Hum Genet 14 (2006) 426-437. This study critically assesses on theoretical grounds the potential of using a HapMap approach, with linkage disequilibrium as a requisite, to detect genes underlying complex diseases and gives examples on how relevant genes might go undetected with this approach.
    • (2006) Eur J Hum Genet , vol.14 , pp. 426-437
    • Terwilliger, J.D.1    Hiekkalinna, T.2
  • 4
    • 0027492226 scopus 로고
    • Multiple sclerosis is associated with genes within or close to the HLA-DR-DQ subregion on a normal DR15,DQ6,Dw2 haplotype
    • Hillert J., and Olerup O. Multiple sclerosis is associated with genes within or close to the HLA-DR-DQ subregion on a normal DR15,DQ6,Dw2 haplotype. Neurology 43 (1993) 163-168
    • (1993) Neurology , vol.43 , pp. 163-168
    • Hillert, J.1    Olerup, O.2
  • 5
    • 27144538977 scopus 로고    scopus 로고
    • A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis
    • Dense SNP typing of the HLA complex in large cohorts demonstrated strong association only with the class II genes.
    • Lincoln M.R., Montpetit A., Cader M.Z., Saarela J., Dyment D.A., Tiislar M., Ferretti V., Tienari P.J., Sadovnick A.D., Peltonen L., et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet 37 (2005) 1108-1112. Dense SNP typing of the HLA complex in large cohorts demonstrated strong association only with the class II genes.
    • (2005) Nat Genet , vol.37 , pp. 1108-1112
    • Lincoln, M.R.1    Montpetit, A.2    Cader, M.Z.3    Saarela, J.4    Dyment, D.A.5    Tiislar, M.6    Ferretti, V.7    Tienari, P.J.8    Sadovnick, A.D.9    Peltonen, L.10
  • 6
    • 0030822571 scopus 로고    scopus 로고
    • Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles
    • Marrosu M.G., Murru M.R., Costa G., Cucca F., Sotgiu S., Rosati G., and Muntoni F. Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles. Am J Hum Genet 61 (1997) 454-457
    • (1997) Am J Hum Genet , vol.61 , pp. 454-457
    • Marrosu, M.G.1    Murru, M.R.2    Costa, G.3    Cucca, F.4    Sotgiu, S.5    Rosati, G.6    Muntoni, F.7
  • 8
    • 26444469579 scopus 로고    scopus 로고
    • Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
    • A large family-based study establishes both predisposing and protective Class II gene alleles, as well as complex interactions in the region.
    • Dyment D.A., Herrera B.M., Cader M.Z., Willer C.J., Lincoln M.R., Sadovnick A.D., Risch N., and Ebers G.C. Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. Hum Mol Genet 14 (2005) 2019-2026. A large family-based study establishes both predisposing and protective Class II gene alleles, as well as complex interactions in the region.
    • (2005) Hum Mol Genet , vol.14 , pp. 2019-2026
    • Dyment, D.A.1    Herrera, B.M.2    Cader, M.Z.3    Willer, C.J.4    Lincoln, M.R.5    Sadovnick, A.D.6    Risch, N.7    Ebers, G.C.8
  • 10
    • 0033975139 scopus 로고    scopus 로고
    • Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease
    • Fogdell-Hahn A., Ligers A., Gronning M., Hillert J., and Olerup O. Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens 55 (2000) 140-148
    • (2000) Tissue Antigens , vol.55 , pp. 140-148
    • Fogdell-Hahn, A.1    Ligers, A.2    Gronning, M.3    Hillert, J.4    Olerup, O.5
  • 14
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a Phase II clinical trial with an altered peptide ligand
    • Bielekova B., Goodwin B., Richert N., Cortese I., Kondo T., Afshar G., Gran B., Eaton J., Antel J., Frank J.A., et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a Phase II clinical trial with an altered peptide ligand. Nat Med 6 (2000) 1167-1175
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10
  • 15
    • 27344459905 scopus 로고    scopus 로고
    • HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice
    • Mice transgenically expressing different human DQ and DR alleles were subjected to MOG immunization. DRB1*15-carrying mice displayed conspicuous demyelination, with modulatory influences by two different DQ alleles.
    • Khare M., Mangalam A., Rodriguez M., and David C.S. HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice. J Neuroimmunol 169 (2005) 1-12. Mice transgenically expressing different human DQ and DR alleles were subjected to MOG immunization. DRB1*15-carrying mice displayed conspicuous demyelination, with modulatory influences by two different DQ alleles.
    • (2005) J Neuroimmunol , vol.169 , pp. 1-12
    • Khare, M.1    Mangalam, A.2    Rodriguez, M.3    David, C.S.4
  • 16
    • 0033405037 scopus 로고    scopus 로고
    • Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity
    • de Graaf K.L., Weissert R., Kjellen P., Holmdahl R., and Olsson T. Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity. Int Immunol 11 (1999) 1981-1988
    • (1999) Int Immunol , vol.11 , pp. 1981-1988
    • de Graaf, K.L.1    Weissert, R.2    Kjellen, P.3    Holmdahl, R.4    Olsson, T.5
  • 17
    • 0035877212 scopus 로고    scopus 로고
    • MHC class II-regulated central nervous system autoaggression and T cell responses in peripheral lymphoid tissues are dissociated in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    • Weissert R., de Graaf K.L., Storch M.K., Barth S., Linington C., Lassmann H., and Olsson T. MHC class II-regulated central nervous system autoaggression and T cell responses in peripheral lymphoid tissues are dissociated in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Immunol 166 (2001) 7588-7599
    • (2001) J Immunol , vol.166 , pp. 7588-7599
    • Weissert, R.1    de Graaf, K.L.2    Storch, M.K.3    Barth, S.4    Linington, C.5    Lassmann, H.6    Olsson, T.7
  • 18
    • 0027448605 scopus 로고
    • The major histocompatibility complex influences myelin basic protein 63-88-induced T cell cytokine profile and experimental autoimmune encephalomyelitis
    • Mustafa M., Vingsbo C., Olsson T., Ljungdahl A., Hojeberg B., and Holmdahl R. The major histocompatibility complex influences myelin basic protein 63-88-induced T cell cytokine profile and experimental autoimmune encephalomyelitis. Eur J Immunol 23 (1993) 3089-3095
    • (1993) Eur J Immunol , vol.23 , pp. 3089-3095
    • Mustafa, M.1    Vingsbo, C.2    Olsson, T.3    Ljungdahl, A.4    Hojeberg, B.5    Holmdahl, R.6
  • 19
    • 0028070131 scopus 로고
    • Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles
    • Mustafa M., Vingsbo C., Olsson T., Issazadeh S., Ljungdahl A., and Holmdahl R. Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles. J Immunol 153 (1994) 3337-3344
    • (1994) J Immunol , vol.153 , pp. 3337-3344
    • Mustafa, M.1    Vingsbo, C.2    Olsson, T.3    Issazadeh, S.4    Ljungdahl, A.5    Holmdahl, R.6
  • 20
    • 0030982033 scopus 로고    scopus 로고
    • Major histocompatibility complex-controlled protective influences on experimental autoimmune encephalomyelitis are peptide specific
    • Issazadeh S., Kjellen P., Olsson T., Mustafa M., and Holmdahl R. Major histocompatibility complex-controlled protective influences on experimental autoimmune encephalomyelitis are peptide specific. Eur J Immunol 27 (1997) 1584-1587
    • (1997) Eur J Immunol , vol.27 , pp. 1584-1587
    • Issazadeh, S.1    Kjellen, P.2    Olsson, T.3    Mustafa, M.4    Holmdahl, R.5
  • 22
    • 13544265645 scopus 로고    scopus 로고
    • Association of haplotypes in the β-chemokine locus with multiple sclerosis
    • Starting from both weak linkage at human 17q and influence from a syntenic region in both mouse and rat EAE, the authors establish association to a cluster of CCL chemokines to MS. Precise identification of discrete genes require further work.
    • Vyshkina T., Shugart Y.Y., Birnbaum G., Leist T.P., and Kalman B. Association of haplotypes in the β-chemokine locus with multiple sclerosis. Eur J Hum Genet 13 (2005) 240-247. Starting from both weak linkage at human 17q and influence from a syntenic region in both mouse and rat EAE, the authors establish association to a cluster of CCL chemokines to MS. Precise identification of discrete genes require further work.
    • (2005) Eur J Hum Genet , vol.13 , pp. 240-247
    • Vyshkina, T.1    Shugart, Y.Y.2    Birnbaum, G.3    Leist, T.P.4    Kalman, B.5
  • 23
    • 20144388185 scopus 로고    scopus 로고
    • Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis
    • Around 70 candidate genes where chosen for SNP typing on the basis of the presence of suggestive linkage peaks and/or immunological function in a fairly large case-control material. Two significantly associated genes came out: IL7R and LAG3. Both genes encode for immunologically active molecules. These associations need confirmation in independent materials.
    • Zhang Z., Duvefelt K., Svensson F., Masterman T., Jonasdottir G., Salter H., Emahazion T., Hellgren D., Falk G., Olsson T., et al. Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes Immun 6 (2005) 145-152. Around 70 candidate genes where chosen for SNP typing on the basis of the presence of suggestive linkage peaks and/or immunological function in a fairly large case-control material. Two significantly associated genes came out: IL7R and LAG3. Both genes encode for immunologically active molecules. These associations need confirmation in independent materials.
    • (2005) Genes Immun , vol.6 , pp. 145-152
    • Zhang, Z.1    Duvefelt, K.2    Svensson, F.3    Masterman, T.4    Jonasdottir, G.5    Salter, H.6    Emahazion, T.7    Hellgren, D.8    Falk, G.9    Olsson, T.10
  • 24
    • 0029011132 scopus 로고
    • Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis
    • Sundvall M., Jirholt J., Yang H.T., Jansson L., Engstrom A., Pettersson U., and Holmdahl R. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat Genet 10 (1995) 313-317
    • (1995) Nat Genet , vol.10 , pp. 313-317
    • Sundvall, M.1    Jirholt, J.2    Yang, H.T.3    Jansson, L.4    Engstrom, A.5    Pettersson, U.6    Holmdahl, R.7
  • 27
    • 0029120178 scopus 로고
    • Genetic analysis of experimental allergic encephalomyelitis in mice
    • Baker D., Rosenwasser O.A., O'Neill J.K., and Turk J.L. Genetic analysis of experimental allergic encephalomyelitis in mice. J Immunol 155 (1995) 4046-4051
    • (1995) J Immunol , vol.155 , pp. 4046-4051
    • Baker, D.1    Rosenwasser, O.A.2    O'Neill, J.K.3    Turk, J.L.4
  • 29
    • 0030931223 scopus 로고    scopus 로고
    • Polygenic control of experimental allergic encephalomyelitis in Biozzi ABH and BALB/c mice
    • Croxford J.L., O'Neill J.K., and Baker D. Polygenic control of experimental allergic encephalomyelitis in Biozzi ABH and BALB/c mice. J Neuroimmunol 74 (1997) 205-211
    • (1997) J Neuroimmunol , vol.74 , pp. 205-211
    • Croxford, J.L.1    O'Neill, J.K.2    Baker, D.3
  • 31
    • 0033104698 scopus 로고    scopus 로고
    • Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct
    • Butterfield R.J., Blankenhorn E.P., Roper R.J., Zachary J.F., Doerge R.W., Sudweeks J., Rose J., and Teuscher C. Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. J Immunol 162 (1999) 3096-3102
    • (1999) J Immunol , vol.162 , pp. 3096-3102
    • Butterfield, R.J.1    Blankenhorn, E.P.2    Roper, R.J.3    Zachary, J.F.4    Doerge, R.W.5    Sudweeks, J.6    Rose, J.7    Teuscher, C.8
  • 32
    • 0034654320 scopus 로고    scopus 로고
    • Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints
    • Blankenhorn E.P., Butterfield R.J., Rigby R., Cort L., Giambrone D., McDermott P., McEntee K., Solowski N., Meeker N.D., Zachary J.F., et al. Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints. J Immunol 164 (2000) 3420-3425
    • (2000) J Immunol , vol.164 , pp. 3420-3425
    • Blankenhorn, E.P.1    Butterfield, R.J.2    Rigby, R.3    Cort, L.4    Giambrone, D.5    McDermott, P.6    McEntee, K.7    Solowski, N.8    Meeker, N.D.9    Zachary, J.F.10
  • 33
    • 0033887729 scopus 로고    scopus 로고
    • Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis
    • Butterfield R.J., Blankenhorn E.P., Roper R.J., Zachary J.F., Doerge R.W., and Teuscher C. Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis. Am J Pathol 157 (2000) 637-645
    • (2000) Am J Pathol , vol.157 , pp. 637-645
    • Butterfield, R.J.1    Blankenhorn, E.P.2    Roper, R.J.3    Zachary, J.F.4    Doerge, R.W.5    Teuscher, C.6
  • 34
    • 0035118184 scopus 로고    scopus 로고
    • Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis
    • Encinas J.A., Lees M.B., Sobel R.A., Symonowicz C., Weiner H.L., Seidman C.E., Seidman J.G., and Kuchroo V.K. Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol 13 (2001) 257-264
    • (2001) Int Immunol , vol.13 , pp. 257-264
    • Encinas, J.A.1    Lees, M.B.2    Sobel, R.A.3    Symonowicz, C.4    Weiner, H.L.5    Seidman, C.E.6    Seidman, J.G.7    Kuchroo, V.K.8
  • 35
    • 0036150686 scopus 로고    scopus 로고
    • Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus
    • Jirholt J., Lindqvist A.K., Karlsson J., Andersson A., and Holmdahl R. Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus. Int Immunol 14 (2002) 79-85
    • (2002) Int Immunol , vol.14 , pp. 79-85
    • Jirholt, J.1    Lindqvist, A.K.2    Karlsson, J.3    Andersson, A.4    Holmdahl, R.5
  • 36
    • 0141425572 scopus 로고    scopus 로고
    • Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis
    • Fillmore P.D., Brace M., Troutman S.A., Blankenhorn E.P., Diehl S., Rincon M., and Teuscher C. Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis. Am J Pathol 163 (2003) 1623-1632
    • (2003) Am J Pathol , vol.163 , pp. 1623-1632
    • Fillmore, P.D.1    Brace, M.2    Troutman, S.A.3    Blankenhorn, E.P.4    Diehl, S.5    Rincon, M.6    Teuscher, C.7
  • 37
    • 26444593052 scopus 로고    scopus 로고
    • Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease
    • Mazon Pelaez I., Vogler S., Strauss U., Wernhoff P., Pahnke J., Brockmann G., Moch H., Thiesen H.J., Rolfs A., and Ibrahim S.M. Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease. Hum Mol Genet 14 (2005) 1977-1989
    • (2005) Hum Mol Genet , vol.14 , pp. 1977-1989
    • Mazon Pelaez, I.1    Vogler, S.2    Strauss, U.3    Wernhoff, P.4    Pahnke, J.5    Brockmann, G.6    Moch, H.7    Thiesen, H.J.8    Rolfs, A.9    Ibrahim, S.M.10
  • 38
    • 33644781695 scopus 로고    scopus 로고
    • eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter
    • Teuscher C., Doerge R.W., Fillmore P.D., and Blankenhorn E.P. eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter. Genetics 172 (2006) 1147-1153
    • (2006) Genetics , vol.172 , pp. 1147-1153
    • Teuscher, C.1    Doerge, R.W.2    Fillmore, P.D.3    Blankenhorn, E.P.4
  • 39
    • 0037438369 scopus 로고    scopus 로고
    • Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations
    • Karlsson J., Zhao X., Lonskaya I., Neptin M., Holmdahl R., and Andersson A. Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol 170 (2003) 1019-1026
    • (2003) J Immunol , vol.170 , pp. 1019-1026
    • Karlsson, J.1    Zhao, X.2    Lonskaya, I.3    Neptin, M.4    Holmdahl, R.5    Andersson, A.6
  • 40
    • 0033105381 scopus 로고    scopus 로고
    • Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9
    • Dahlman I., Jacobsson L., Glaser A., Lorentzen J.C., Andersson M., Luthman H., and Olsson T. Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9. J Immunol 162 (1999) 2581-2588
    • (1999) J Immunol , vol.162 , pp. 2581-2588
    • Dahlman, I.1    Jacobsson, L.2    Glaser, A.3    Lorentzen, J.C.4    Andersson, M.5    Luthman, H.6    Olsson, T.7
  • 41
    • 0032725297 scopus 로고    scopus 로고
    • Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18
    • Dahlman I., Wallstrom E., Weissert R., Storch M., Kornek B., Jacobsson L., Linington C., Luthman H., Lassmann H., and Olsson T. Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18. Hum Mol Genet 8 (1999) 2183-2190
    • (1999) Hum Mol Genet , vol.8 , pp. 2183-2190
    • Dahlman, I.1    Wallstrom, E.2    Weissert, R.3    Storch, M.4    Kornek, B.5    Jacobsson, L.6    Linington, C.7    Luthman, H.8    Lassmann, H.9    Olsson, T.10
  • 42
    • 0033557725 scopus 로고    scopus 로고
    • A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10
    • Roth M.P., Viratelle C., Dolbois L., Delverdier M., Borot N., Pelletier L., Druet P., Clanet M., and Coppin H. A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10. J Immunol 162 (1999) 1917-1922
    • (1999) J Immunol , vol.162 , pp. 1917-1922
    • Roth, M.P.1    Viratelle, C.2    Dolbois, L.3    Delverdier, M.4    Borot, N.5    Pelletier, L.6    Druet, P.7    Clanet, M.8    Coppin, H.9
  • 43
    • 0034141543 scopus 로고    scopus 로고
    • Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis
    • Bergsteinsdottir K., Yang H.T., Pettersson U., and Holmdahl R. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. J Immunol 164 (2000) 1564-1568
    • (2000) J Immunol , vol.164 , pp. 1564-1568
    • Bergsteinsdottir, K.1    Yang, H.T.2    Pettersson, U.3    Holmdahl, R.4
  • 45
    • 1542784426 scopus 로고    scopus 로고
    • Adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in experimental allergic encephalomyelitis
    • Fillmore P.D., Blankenhorn E.P., Zachary J.F., and Teuscher C. Adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in experimental allergic encephalomyelitis. Am J Pathol 164 (2004) 167-175
    • (2004) Am J Pathol , vol.164 , pp. 167-175
    • Fillmore, P.D.1    Blankenhorn, E.P.2    Zachary, J.F.3    Teuscher, C.4
  • 46
    • 7244261723 scopus 로고    scopus 로고
    • Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis: implications for the genetics of multiple sclerosis
    • Teuscher C., Bunn J.Y., Fillmore P.D., Butterfield R.J., Zachary J.F., and Blankenhorn E.P. Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis: implications for the genetics of multiple sclerosis. Am J Pathol 165 (2004) 1593-1602
    • (2004) Am J Pathol , vol.165 , pp. 1593-1602
    • Teuscher, C.1    Bunn, J.Y.2    Fillmore, P.D.3    Butterfield, R.J.4    Zachary, J.F.5    Blankenhorn, E.P.6
  • 47
    • 3142756413 scopus 로고    scopus 로고
    • An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci
    • This study represents the first application of advanced intercross line mapping (AIL) in rats, demonstrating clustering of EAE-regulating genes within Eae18 QTL.
    • Jagodic M., Becanovic K., Sheng J.R., Wu X., Backdahl L., Lorentzen J.C., Wallstrom E., and Olsson T. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. J Immunol 173 (2004) 1366-1373. This study represents the first application of advanced intercross line mapping (AIL) in rats, demonstrating clustering of EAE-regulating genes within Eae18 QTL.
    • (2004) J Immunol , vol.173 , pp. 1366-1373
    • Jagodic, M.1    Becanovic, K.2    Sheng, J.R.3    Wu, X.4    Backdahl, L.5    Lorentzen, J.C.6    Wallstrom, E.7    Olsson, T.8
  • 48
    • 11844298443 scopus 로고    scopus 로고
    • Resolution of a 16.8-Mb autoimmunity-regulating rat chromosome 4 region into multiple encephalomyelitis quantitative trait loci and evidence for epistasis
    • This study represents one of the first demonstrations of epistatic interactions between regions that regulate neuroinflammation.
    • Jagodic M., Marta M., Becanovic K., Sheng J.R., Nohra R., Olsson T., and Lorentzen J.C. Resolution of a 16.8-Mb autoimmunity-regulating rat chromosome 4 region into multiple encephalomyelitis quantitative trait loci and evidence for epistasis. J Immunol 174 (2005) 918-924. This study represents one of the first demonstrations of epistatic interactions between regions that regulate neuroinflammation.
    • (2005) J Immunol , vol.174 , pp. 918-924
    • Jagodic, M.1    Marta, M.2    Becanovic, K.3    Sheng, J.R.4    Nohra, R.5    Olsson, T.6    Lorentzen, J.C.7
  • 50
    • 2542541258 scopus 로고    scopus 로고
    • Parent-of-origin effect in multiple sclerosis: observations in half-siblings
    • Ebers G.C., Sadovnick A.D., Dyment D.A., Yee I.M., Willer C.J., and Risch N. Parent-of-origin effect in multiple sclerosis: observations in half-siblings. Lancet 363 (2004) 1773-1774
    • (2004) Lancet , vol.363 , pp. 1773-1774
    • Ebers, G.C.1    Sadovnick, A.D.2    Dyment, D.A.3    Yee, I.M.4    Willer, C.J.5    Risch, N.6
  • 52
    • 2942724439 scopus 로고    scopus 로고
    • The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis
    • Greve B., Vijayakrishnan L., Kubal A., Sobel R.A., Peterson L.B., Wicker L.S., and Kuchroo V.K. The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J Immunol 173 (2004) 157-163
    • (2004) J Immunol , vol.173 , pp. 157-163
    • Greve, B.1    Vijayakrishnan, L.2    Kubal, A.3    Sobel, R.A.4    Peterson, L.B.5    Wicker, L.S.6    Kuchroo, V.K.7
  • 55
    • 33746389790 scopus 로고    scopus 로고
    • Definition of a 1.06 Mb region linked to neuroinflammation in humans, rats and mice
    • This study demonstrates a combined effort of in silico intergenomic mapping and advanced intercrossed line mapping that resolves QTL to a region containing 13 candidate genes for the regulation of neuroinflammation in humans, rats and mice.
    • Ockinger J., Serrano-Fernandez P., Moller S., Ibrahim S.M., Olsson T., and Jagodic M. Definition of a 1.06 Mb region linked to neuroinflammation in humans, rats and mice. Genetics 173 (2006) 1539-1545. This study demonstrates a combined effort of in silico intergenomic mapping and advanced intercrossed line mapping that resolves QTL to a region containing 13 candidate genes for the regulation of neuroinflammation in humans, rats and mice.
    • (2006) Genetics , vol.173 , pp. 1539-1545
    • Ockinger, J.1    Serrano-Fernandez, P.2    Moller, S.3    Ibrahim, S.M.4    Olsson, T.5    Jagodic, M.6
  • 56
    • 20944445879 scopus 로고    scopus 로고
    • MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    • By positional cloning of Vra4, a QTL on rat chromosome 10 that regulates MHC class II expression after nerve injury, the authors have identified the regulatory gene, MHC class II transactivator (Mhc2ta). The polymorphism in the type III promoter of Mhc2ta confers susceptibility to several common complex diseases with inflammatory components, including multiple sclerosis, rheumatoid arthritis and myocardial infarction.
    • Swanberg M., Lidman O., Padyukov L., Eriksson P., Akesson E., Jagodic M., Lobell A., Khademi M., Borjesson O., Lindgren C.M., et al. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat Genet 37 (2005) 486-494. By positional cloning of Vra4, a QTL on rat chromosome 10 that regulates MHC class II expression after nerve injury, the authors have identified the regulatory gene, MHC class II transactivator (Mhc2ta). The polymorphism in the type III promoter of Mhc2ta confers susceptibility to several common complex diseases with inflammatory components, including multiple sclerosis, rheumatoid arthritis and myocardial infarction.
    • (2005) Nat Genet , vol.37 , pp. 486-494
    • Swanberg, M.1    Lidman, O.2    Padyukov, L.3    Eriksson, P.4    Akesson, E.5    Jagodic, M.6    Lobell, A.7    Khademi, M.8    Borjesson, O.9    Lindgren, C.M.10
  • 57
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • This study identifies an autoimmunity-predisposing gene both in humans and mice. The study implicates common allelic variation in the expression levels of alternative splice forms of a key negative regulator of the T lymphocyte immune response, CTLA4, regulating Graves' disease, autoimmune hypothyroidism and type 1 diabetes in humans and diabetes in mice.
    • Ueda H., Howson J.M., Esposito L., Heward J., Snook H., Chamberlain G., Rainbow D.B., Hunter K.M., Smith A.N., Di Genova G., et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423 (2003) 506-511. This study identifies an autoimmunity-predisposing gene both in humans and mice. The study implicates common allelic variation in the expression levels of alternative splice forms of a key negative regulator of the T lymphocyte immune response, CTLA4, regulating Graves' disease, autoimmune hypothyroidism and type 1 diabetes in humans and diabetes in mice.
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5    Chamberlain, G.6    Rainbow, D.B.7    Hunter, K.M.8    Smith, A.N.9    Di Genova, G.10
  • 58
    • 32844460938 scopus 로고    scopus 로고
    • Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
    • The authors identify a susceptibility gene to immunologically mediated glomerulonephritis, Fcgr3, and demonstrate that copy number variation of the orthologous rat and human genes is predisposing for the disease.
    • Aitman T.J., Dong R., Vyse T.J., Norsworthy P.J., Johnson M.D., Smith J., Mangion J., Roberton-Lowe C., Marshall A.J., Petretto E., et al. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439 (2006) 851-855. The authors identify a susceptibility gene to immunologically mediated glomerulonephritis, Fcgr3, and demonstrate that copy number variation of the orthologous rat and human genes is predisposing for the disease.
    • (2006) Nature , vol.439 , pp. 851-855
    • Aitman, T.J.1    Dong, R.2    Vyse, T.J.3    Norsworthy, P.J.4    Johnson, M.D.5    Smith, J.6    Mangion, J.7    Roberton-Lowe, C.8    Marshall, A.J.9    Petretto, E.10
  • 59
    • 0029982537 scopus 로고    scopus 로고
    • Genetic analysis of autoimmune disease
    • Vyse T.J., and Todd J.A. Genetic analysis of autoimmune disease. Cell 85 (1996) 311-318
    • (1996) Cell , vol.85 , pp. 311-318
    • Vyse, T.J.1    Todd, J.A.2
  • 61
    • 0027447712 scopus 로고
    • Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive
    • Sedgwick J.D., Schwender S., Gregersen R., Dorries R., and ter Meulen V. Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive. J Exp Med 177 (1993) 1145-1152
    • (1993) J Exp Med , vol.177 , pp. 1145-1152
    • Sedgwick, J.D.1    Schwender, S.2    Gregersen, R.3    Dorries, R.4    ter Meulen, V.5
  • 62
    • 0031013236 scopus 로고    scopus 로고
    • Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats
    • Popovich P.G., Wei P., and Stokes B.T. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 377 (1997) 443-464
    • (1997) J Comp Neurol , vol.377 , pp. 443-464
    • Popovich, P.G.1    Wei, P.2    Stokes, B.T.3
  • 64
    • 0035952354 scopus 로고    scopus 로고
    • Neurodegeneration and glial activation patterns after mechanical nerve injury are differentially regulated by non-MHC genes in congenic inbred rat strains
    • Lundberg C., Lidman O., Holmdahl R., Olsson T., and Piehl F. Neurodegeneration and glial activation patterns after mechanical nerve injury are differentially regulated by non-MHC genes in congenic inbred rat strains. J Comp Neurol 431 (2001) 75-87
    • (2001) J Comp Neurol , vol.431 , pp. 75-87
    • Lundberg, C.1    Lidman, O.2    Holmdahl, R.3    Olsson, T.4    Piehl, F.5
  • 65
    • 0242609171 scopus 로고    scopus 로고
    • Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS
    • Lidman O., Swanberg M., Horvath L., Broman K.W., Olsson T., and Piehl F. Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS. J Neurosci 23 (2003) 9817-9823
    • (2003) J Neurosci , vol.23 , pp. 9817-9823
    • Lidman, O.1    Swanberg, M.2    Horvath, L.3    Broman, K.W.4    Olsson, T.5    Piehl, F.6
  • 66
    • 33644974688 scopus 로고    scopus 로고
    • Secondary progressive multiple sclerosis: current knowledge and future challenges
    • Rovaris M., Confavreux C., Furlan R., Kappos L., Comi G., and Filippi M. Secondary progressive multiple sclerosis: current knowledge and future challenges. Lancet Neurol 5 (2006) 343-354
    • (2006) Lancet Neurol , vol.5 , pp. 343-354
    • Rovaris, M.1    Confavreux, C.2    Furlan, R.3    Kappos, L.4    Comi, G.5    Filippi, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.