Herpes simplex virus vectors for gene transfer to the nervous system

Journal of NeuroVirology

Volumn 3, Issue SUPPL. 1, 1997, Pages

  Goins, William F ^a   Krisky, Dave ^a   Marconi, Peggy ^a   Oligino, Tom ^a   Ramakrishnan, Ramesh ^a   Poliani, P Luigi ^a   Fink, David J ^a   Glorioso, Joseph C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Gene therapy; Gene transfer; Herpes simplex virus; Latency; Neurons

Indexed keywords

EXTRACHROMOSOMAL DNA; VIRUS VECTOR;

ANIMAL CELL; CELL METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; DEFECTIVE VIRUS; GENE EXPRESSION; GENE FUNCTION; GENE THERAPY; GENE TRANSFER; GENETIC ENGINEERING; HERPES SIMPLEX VIRUS; IMMEDIATE EARLY GENE; MOLECULAR BIOLOGY; NEUROLOGIC DISEASE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; TRANSGENE; VIRUS GENE; VIRUS LATENCY; VIRUS RECOMBINANT; VIRUS REPLICATION;

ANIMALS; DNA REPLICATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; GENETIC VECTORS; GENOME, VIRAL; HUMANS; MODELS, BIOLOGICAL; NERVOUS SYSTEM; NEURONS; SIMPLEXVIRUS; TRANSFECTION; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0030919279     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (91)

1. Ackland-Berglund C, Davido D, Leib DA (1995). The role of the cAMP-response element and TATA box in expression of the herpes simplex virus type 1 latency-associated transcripts. Virology 210: 141-151.
2. Anderson J, Garber D, Meaney C, Breakfield X (1992). Gene transfer into mammalian central nervous system using herpes virus vectors; extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter. Hum Gene Ther 3: 487-499.
3. Axelrod JD, Reagan MS, Majors J (1993). GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo. Genes Dev 7: 857-869.
4. Batchelor AH, O'Hare PO (1990). Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1. J Virol 64: 3269-3279.
5. Batchelor AH, O'Hare PO (1992). Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity. J Virol 66: 3573-3582.
6. Batchelor AH, Wilcox KW, O'Hare P (1994). Binding and repression of the latency-associated promoter of herpes simplex virus by the immediate early 175K protein. J Gen Virol 75: 753-767.
7. Batterson W, Roizman B (1983). Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha-genes. J Virol 46: 371-377.
8. Bloom D, Hill J, Devi-Rao G, Wagner E, Feldman L, Stevens J (1996). A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation. J Virol 70: 2449-2459.
9. Bossone SA, Asselin C, Patel AJ, Marcu KB (1992). MAZ a zinc finger protein binds to c-MYC and C2 gene sequences regulating transcriptionally initiation and termination. Proc Natl Acad Sci USA 89: 7452-7456.
10. Campadelli G, Brandimarti R, Lazzaro CD, Ward P, Roizman B, Torrisi M (1993). Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through Golgi following infection with herpes simplex virus 1. Proc Natl Acad Sci USA 90: 2798-2802.
11. Carey M, Leatherwood J, Ptashne M (1990). A potent GAL4 derivative activates transcription at a distance in vitro. Science 247: 710-712.
12. Chasman DI, Leatherwood M, Carey M, Ptashne M, Kornberg RD (1989). Activation of yeast polymerase II transcription by herpes virus VP16 and GAL4 derivative in vitro. Mol Cell Biol 9: 4746-4749.
13. Chen X, Schmidt M, Goins W, Fink D, Hendricks R, Glorioso J (1997). HSV-1 vector-mediated lacZ gene transfer to the nervous system: long-term gene expression using the viral latency-active promoter. Gene Ther (submitted).
14. Chen X, Schmidt MC, Goins WF, Glorioso JC (1995). Two herpes simplex virus type-1 latency active promoters differ in their contribution to latency-associated transcript expression during lytic and latent infection. J Virol 69: 7899-7908.
15. Cook ML, Stevens JG (1973). Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence of intraaxonal transport of infection. Infect Immun 7: 272-288.
16. Croen KD, Ostrove JM, Dragovic LJ, Smialek JE, Straus SE (1987). Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene 'anti-sense' transcript by in situ hybridization. New Engl J Med 317: 1427-1432.
17. Deiss L, Chou J, Frenkel N (1986). Functional domains within the sequence involved in the cleavage-packaging of herpes simplex virus DNA. J Virol 57: 605-618.
18. DeLuca NA, McCarthy AM, Schaffer PA (1985). Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J Virol 56: 558-570.
19. DeLuca NA, Schaffer PA (1985). Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4. Mol. Cell. Biol 5: 1997-2008.
20. Deshmane SL, Fraser NW (1989). During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure. J Virol 63: 943-947.
21. Devi-Rao GB, Goddart SA, Hecht LM, Rochford R, Rice MK, Wagner EK (1991). Relationship between polyadenylated and nonpolyadenylated, HSV type 1 latency-associated transcripts. J Gen Virol 65: 2179-2190.
22. Dobson AT, Margolis TP, Gomes WA, Feldman LT (1995). In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter. J Virol 69: 2264-2270.
23. Dobson AT, Sederati F, Devi-Rao G, Flanagan WM, Farrell MJ, Stevens JG, Wagner EK, Feldman LT (1989). Identification of the latency-associated transcript promoter by expression of rabbit β-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J Virol 63: 3844-3851.
24. Efstathiou S, Minson A, Field H, Anderson J, Wildy P (1986). Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in human. J Virol 57: 446-455.
25. Farrell MJ, Dobson AT, Feldman LT (1991). Herpes simplex virus latency-associated transcript is a stable intron. Proc Natl Acad Sci USA 88: 790-794.
26. Farrell MJ, Margolis TP, Gomes WA, Feldman LT (1994). Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo. J Virol 68: 5337-5343.
27. Fink DJ, Sternberg LR, Weber PC, Mata M, Goins WF, Glorioso JC (1992). In vivo expression of β-galactosidase in hippocampal neurons by HSV-mediated gene transfer. Hum Gene Ther 3: 11-19.
28. French S, Goins W, Montesanti D, Kinniburgh A, Schmidt M, Glorioso J (1997). In vitro studies of the TATA-less latency active promoter (LAP2) of herpes simplex virus type-1 identify essential promoter elements which form non-B-DNA structures. J Gen Virol (submitted).
29. French SW, Schmidt MA, Glorioso JC (1996). Involvement of a high-mobility-group protein in the transcriptional activity of herpes simplex virus latency-active promoter 2. Mol Cell Biol 16: 5393-5399.
30. Goins WF, Sternberg LR, Croen KD, Krause PR, Hendricks RL, Fink DJ, Straus SE, Levine M, Glorioso JC (1994). A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J Virol 68: 2239-2252.
31. Hill JM, Sedarati F, Javier RT, Wagner EK, Stevens JG (1990). Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174: 117-125.
32. Ho DY, Mocarski ES (1989). Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc Natl Acad Sci USA 86: 7596-7600.
33. Holland LE, Anderson KP, Shipman C, Wagner EK (1980). Viral DNA synthesis is required for efficient expression of specific herpes simplex virus type 1 mRNA. Virology 101: 10-24.
34. Honess R, Roizman B (1974). Regulation of herpes simplex virus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J Virol 14: 8-19.
35. Johnson D, Spear P (1982). Monensin inhibits the processing of herpes simplex virus glycoproteins, their transport to the cell surface, and the egress of virions from infected cells. J Virol 43: 1102-1112.
36. Johnson P, Miyanohara A, Levine F, Cahill T, Friedmann T (1992). Cytotoxicity of a replication-defective mutant herpes simplex virus type 1. J Virol 66: 2952-2965.
37. Johnson P, Wang M, Friedmann T (1994). Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the viron host shutoff function. J Virol 68: 6347-6362.
38. Kenny JI, Krebs FC, Hartle HT, Gartner AE, Chatton B, Leiden JM, Hoeffler JP, Weber PC, Wigdahl B (1994). Identification of a second ATF/CREB-like element in the herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) promoter. Virology 200: 220-235.
39. Kolluri R, Torrey TA, Kinniburgh AJ (1992). A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif. Nucleic Acids Res 20: 111-116.
40. Krisky DM, Marconi PC, Ramakrishnan R, Mata M, Rouse RJD, Fink DJ, Glorioso JC (1997). Deletion of multiple immediate early genes from herpes simplex virus reduces cytotoxicity and improves gene transfer to neurons in culture. J Virol (submitted).
41. Kristie T, Sharp P (1993). Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by herpes simplex virus α-trans-induction factor (VP16). J Biol Chem 268: 6525-6534.
42. Kwong AD, Kruper JA, Frenkel N (1988). Herpes simplex virus virion host shutoff function. J Virol 62: 912-921.
43. Leib DA, Nadeau KC, Rundle SA, Schaffer PA (1991). Promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Proc Natl Acad Sci USA 88: 48-52.
44. Leiden J, Frenkel N, Rapp F (1980). Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines. J Virol 33: 272-285.
45. Lokensgard JR, Bloom DC, Dobson AT, Feldman LT (1994). Long-term promoter activity during herpes simplex virus latency. J Virol 68: 7148-7158.
46. Maggioncalda J, Mehta A, Fraser NW, Block TM (1994). Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5′ end of the 2.0-kilobase transcript. J Virol 68: 7816-7824.
47. Marconi P, Krisky D, Oligino T, Poliani PL, Ramakrishnan R, Goins WF, Fink DJ, Glorioso JC (1996). Replication-defective HSV vectors for gene transfer in vivo. Proc Natl Acad Sci USA 93: 11319-11320.
48. Margolis TP, Bloom DC, Dobson AT, Feldman LT, Stevens JG (1993). Decreased reporter gene expression during latent infection with HSV LAT promoter constructs. Virology 197: 585-592.
49. Mavromara-Nazos P, Roizman B (1987). Activation of herpes simplex virus 1 γ2 genes by viral DNA replication. Virology 161: 593-598.
50. McCarthy AM, McMahan L, Schaffer PA (1989). Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient. J Virol 63: 18-27.
51. Mellerick DM, Fraser N (1987). Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state. Virology 158: 265-275.
52. Newcomb W, Brown J (1994). Induced extrusion of DNA from the capsid of herpes simplex virus type 1. J Virol 68: 443-440.
53. Nicosia M, Deshmane SL, Zabolotny JM, Valyi-Nagy T, Fraser NW (1993). Herpes simplex virus type 1 Latency-Associated Transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J Virol 67: 7276-7283.
54. Oligino T, Poliani PL, Marconi P, Bender MA, Schmidt MC, Fink DJ, Glorioso JC (1996). In vivo transgene activation from an HSV-based gene vector by GAL4:VP16. Gene Ther 3: 892-899.
55. Oligino T, Poliani PL, Wang Y, Tsai SY, O'Malley BW, Glorioso JC (1997). Drug inducible transgene expression in brain using a herpes simplex virus vector. J Virol (submitted).
56. Oroskar A, Read G (1989). Control of mRNA stability by the virion host shutoff function of herpes simplex virus. J Virol 63: 1897-1906.
57. Palella T, Hidaka Y, Silverman L, Levine M, Glorioso J, Kelley W (1989). Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus type 1 vector. Gene 80: 137-144.
58. Perng G-C, Chokephaibulkit K, Thompson R, Sawtell N, Slanina S, Ghiasi H, Nesburn A, Wechsler S (1996). The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. J Virol 70: 282-291.
59. Postel EH, Mango SE, Flint SJ (1989). A nuclease-hypersensitive element of the human c-myc promoter interacts with a transcription initiation factor. Mol Cell Biol 9: 5123-5133.
60. Preston C, Frame M, Campbell M (1988). A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence. Cell 52: 425-434.
61. Pyrc JJ, Moberg KH, Hall DJ (1992). Isolation of a Novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter. Biochemistry 31: 4102-4110.
62. Radar KA, Ackland-Berglund CE, Miller JK, Pepose JS, Leib DA (1993). In vivo characterization of site-directed mutations in the promoter of the herpes simplex vius type 1 latency-associated transcripts. J. Gen. Virol. 74: 1859-1869.
63. Ramakrishnan R, Krisky D, Marconi P, Poliani PL, Laquerre S, Schmidt M, Fink DJ, Glorioso JC (1997). HSV immediate early proteins participate in promoter silencing during the establishment of latency. Science (submitted).
64. Ramakrishnan R, Levine M, Fink D (1994). PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J Virol 68: 7083-7091.
65. Rasty S, Thatikunta P, Gordon J, Khalili K, Amini S, Glorioso JC (1996). Human immunodeficiency virus tat gene transfer to the murine central nervous system using a replication-defective herpes simplex virus vector stimulates transforming growth factor beta 1 gene expression. Proc Natl Acad Sci USA 93: 6073-6078.
66. Read GS, Frenkel N (1983). Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of α (immediate early) viral polypeptides. J Virol 46: 498-512.
67. Rice S, Long M, Lam V, Spencer C (1994). RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection. J Virol 68: 988-1001.
68. Rivera-Gonzalez R, Imbalzano AN, Gu B, DeLuca NA (1994). The role of ICP4 repressor activity in the temporal regulation of the IE-3 and latency-associated transcript promoter during herpes simplex virus type-1 infection. Virology 202: 550-564.
69. Rock D, Fraser N (1985). Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region. J Virol 55: 849-852.
70. Roizman B, Sears A (1996). Herpes simplex viruses and their replication. In: Fields Virology (B.N. Fields, D.M. Knipe, P.M. Howley, R.M. Chanock, M.S. Hirsch, J.L. Melnick, T.P. Monath and B. Roizman, eds.). Lippincott-Raven: Philadelphia, PA, pp 2231-2295.
71. Sacks W, Greene C, Aschman D, Schaffer P (1985). Herpes simplex virus type 1 ICP27 is essential regulatory protein. J Virol 55: 796-805.
72. Sadowski I, Ma J, Triezenberg S, Ptashne M (1988). GAL4/VP16 is an unusually potent transcriptional activator. Nature 335: 563-564.
73. Sandri-Goldin R, Hibbard M (1996). The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-sm antiserum, and the C terminus appears to be required for this interaction. J Virol 70: 108-118.
74. Sawtell NM, Thompson RL (1992). Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. J Virol 66: 2157-2169.
75. Soares MK, Hwang D-Y, Schmidt MC, Fink DJ, Glorioso JC (1996). Cis-acting elements involved in transcriptional regulation of the herpes simplex virus type-1 latency-associated promoter 1 (LAP1) in vitro and in vivo. J Virol 70: 5384-5394.
76. Spear P (1993). Membrane fusion induced by herpes simplex virus. In: Viral Fusion Mechanisms (J. Bentz, ed.). CRC Press: Boca Raton, pp 201-32.
77. Spivack JG, Fraser NW (1987). Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J Virol 61: 3841-3847.
78. Spivack JG, Woods GM, Fraser NW (1991). Identification of a novel latency-specific splice donor signal within HSV type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT. J Virol 65: 6800-6810.
79. Stevens JG (1989). Human herpesviruses: a consideration of the latent state. Microbiol Rev 53: 318-332.
80. Stevens JG, Wagner EK, Devi-Rao GB, Cook ML, Feldman LT (1987). RNA complementary to a herpesviruses α gene mRNA is prominent in latently infected neurons. Science 255: 1056-1059.
81. Stinski MF, Roehr TJ (1985). Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virus-specific trans-acting components. J Virol 55: 431-441.
82. Thomsen DR, Sternberg RM, Goins WF, Stinski MF (1984). Promoter regulatory region of the major immediate early gene of human cytomegalovirus. Proc Natl Acad Sci USA 81: 659-663.
83. Varmuza SL, Smiley JR (1985). Signals for site-specific cleavage of HSV DNA: maturation involves two separate cleavage events at sites distal to the recognition site. Cell 41: 792-802.
84. Wagner EK, Flanagan WM, Devi-Rao GB, Zhang YF, Hill JM, Anderson KP, Stevens JG (1988). The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J Virol 62: 4577-4585.
85. Wang K, Krause PR, Straus SE (1995). Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts. J Virol 69: 2873-2880.
86. Wang Y, BW O'Malley Jr, Tsai S, O'Malley B (1994). A novel regulatory system for gene transfer. Proc Natl Acad Sci USA 91: 8180-8184.
87. Werstuck G, Capone J (1993). An unusual cellular factor potentiates protein-DNA complex assembly Oct-1 and Vmw65. J Biol Chem 268: 1272-1278.
88. Wu N, Watkins SC, Schaffer PA, DeLuca NA (1996). Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in immediate-early genes encoding ICP4, ICP27, and ICP22. J Virol 70: 6358-6368.
89. Xu L, Schaffner W, Rungger D (1993). Transcription activation by recombinant GAL4/VP16 in the Xenopus oocyte. Nucl Acids Res 21: 2775.
90. Zwaagstra J, Ghiasi H, Nesburn AB, Wechsler SL (1989). In vitro promoter activity associated with the latency-associated transcript gene of herpes simplex virus type 1. J Gen Virol 70: 2163-2169.
91. Zwaagstra JC, Ghiasi H, Nesburn AB, Wechsler SL (1991). Identification of a major regulatory sequence in the latency-associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1). Virology 182: 287-297.