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Coordination Chemistry Reviews

Volumn 232, Issue 1-2, 2002, Pages 127-135

Mechanisms of cytotoxicity and antitumor activity of gold(I) phosphine complexes: The possible role of mitochondria

(3) McKeage, Mark J a Maharaj, Lenushka a Berners Price, Susan J b

a UNIVERSITY OF AUCKLAND (New Zealand)

b UNIVERSITY OF WESTERN AUSTRALIA (Australia)

Author keywords

Antitumor agents; Cytotoxicity; Gold(I) phosphines; Mitochondria; Mode of action; Selective toxicity

Indexed keywords

AURANOFIN; BIS[1,2 BIS(DI N PYRIDYLPHOSPHINO)ETHANE]GOLD CHLORIDE COMPLEX; DNA POLYMERASE; GOLD BIS[1,2 BIS(DIPHENYLPHOSPHINO)ETHANE] CHLORIDE; GOLD COMPLEX; GOLD DERIVATIVE; GOLD PHOSPHINE COMPLEX; PHOSPHINE DERIVATIVE; PYRIDINE DERIVATIVE; TRIETHYLPHOSPHINE GOLD; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTHRITIS; ARTICLE; COLONY FORMATION; COMPLEX FORMATION; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; HYDROPHILICITY; LEUKEMIA CELL; LIFESPAN; LIPOPHILICITY; LIVER CELL; METAL BINDING; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROCESS OPTIMIZATION; PROTEIN CROSS LINKING; PROTEIN DNA INTERACTION; RAT; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION;

EID: 0036783521 PISSN: 00108545 EISSN: None Source Type: Journal
DOI: 10.1016/S0010-8545(02)00048-6 Document Type: Review

Times cited : (239)

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