Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes

Cancer Chemotherapy and Pharmacology

Volumn 46, Issue 5, 2000, Pages 343-350

  McKeage, Mark J ^a   Berners Price, Susan J ^b   Galettis, Peter ^a   Bowen, Richard J ^b   Brouwer, Wandy ^a   Ding, Li ^a   Zhuang, Li ^c   Baguley, Bruce C ^c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b GRIFFITH UNIVERSITY   (Australia)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Cellular uptake; Hydrophobicity; Lipophilic cation; Mitochondria; Protein binding

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; GOLD BIS[1,2 BIS(DIPHENYLPHOSPHINO)ETHANE] CHLORIDE; GOLD COMPLEX; PHOSPHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GRAFT; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG UPTAKE; HUMAN; LIPOPHILICITY; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL;

EID: 0033748259     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800000166     Document Type: Article

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