p53-mediated downregulation of Chk1 abrogates the DNA damage-induced G2M checkpoint in K562 cells, resulting in increased apoptosis

British Journal of Haematology

Volumn 116, Issue 2, 2002, Pages 421-428

  Cummings, Michele ^a   Siitonen, Timo ^a   Higginbottom, Karen ^a   Newland, Adrian C ^a   Allen, Paul D ^a  

^a INSTITUTE OF UROLOGY AND NEPHROLOGY   (United Kingdom)

Author keywords

Apoptosis; Chk1 downregulation; G2 arrest abrogation; K562 cells; p53

Indexed keywords

CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 1; ETOPOSIDE; NOCODAZOLE; PROTEIN KINASE; PROTEIN P52; TYROSINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL STRAIN K 562; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; FUSION GENE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOSIS; MITOSIS INDEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; ETOPOSIDE; G2 PHASE; GENE EXPRESSION REGULATION; GENES, P53; HUMANS; K562 CELLS; PHOSPHORYLATION; PROTEIN KINASES; TRANSFECTION;

EID: 0036179154     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03262.x     Document Type: Article

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