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Volumn 55, Issue 4, 2007, Pages 219-229

Negative signals from FcεRI engagement attenuate mast cell functions

Author keywords

Fc RI; Mast cell; Negative regulation; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; HIGH AFFINITY RECEPTOR FOR IMMUNOGLOBULIN E; LAT PROTEIN; LIPID PHOSPHATASE; PHOSPHATASE; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; RAB PROTEIN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; PROTEIN SUBUNIT; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 34547878349     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-007-0028-4     Document Type: Review
Times cited : (16)

References (75)
  • 1
    • 0037255263 scopus 로고    scopus 로고
    • Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor
    • Abramson J., Rozenblum G. and Pecht I. (2003): Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor. Eur. J. Immunol., 33, 85-91.
    • (2003) Eur. J. Immunol , vol.33 , pp. 85-91
    • Abramson, J.1    Rozenblum, G.2    Pecht, I.3
  • 2
    • 0036033110 scopus 로고    scopus 로고
    • An unusual inhibitory receptor-the mast cell function-associated antigen (MAFA)
    • Abramson J., Xu R. and Pecht I. (2002): An unusual inhibitory receptor-the mast cell function-associated antigen (MAFA). Mol. Immunol., 38, 1307-1313.
    • (2002) Mol. Immunol , vol.38 , pp. 1307-1313
    • Abramson, J.1    Xu, R.2    Pecht, I.3
  • 3
    • 10344222887 scopus 로고    scopus 로고
    • The ins and outs of IgE - dependent mast-cell exocytosis
    • Blank U. and Rivera J. (2004): The ins and outs of IgE - dependent mast-cell exocytosis. Trends Immunol., 25, 266-273.
    • (2004) Trends Immunol , vol.25 , pp. 266-273
    • Blank, U.1    Rivera, J.2
  • 5
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley L. C. and Neel B. G. (1999): New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA, 96, 4240-4245.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 6
    • 0030472724 scopus 로고    scopus 로고
    • Critical role for the tyrosine kinase Syk in signaling through the high affinity IgE receptor of mast cells
    • Costello P. S., Turner M., Walters A. E., Cunningham C. N., Bauer P. H., Downward J. and Tybulewicz V. L. (1996): Critical role for the tyrosine kinase Syk in signaling through the high affinity IgE receptor of mast cells. Oncogene, 13, 2595-2605.
    • (1996) Oncogene , vol.13 , pp. 2595-2605
    • Costello, P.S.1    Turner, M.2    Walters, A.E.3    Cunningham, C.N.4    Bauer, P.H.5    Downward, J.6    Tybulewicz, V.L.7
  • 7
    • 1342292522 scopus 로고    scopus 로고
    • Phosphoinositide 3 - kinase: Diverse roles in immune cell activation
    • Deane J. A. and Fruman D.A. (2004): Phosphoinositide 3 - kinase: diverse roles in immune cell activation. Annu. Rev. Immunol., 22, 563-598.
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 563-598
    • Deane, J.A.1    Fruman, D.A.2
  • 8
    • 0037010186 scopus 로고    scopus 로고
    • CIN85/CMS family of adaptor molecules
    • Dikic I. (2002): CIN85/CMS family of adaptor molecules. FEBS Lett., 529, 110-115.
    • (2002) FEBS Lett , vol.529 , pp. 110-115
    • Dikic, I.1
  • 9
    • 3142726114 scopus 로고    scopus 로고
    • The Cbl family and other ubiquitin ligases: Destructive forces in control of antigen receptor signaling
    • Duan L., Reddi A. L., Ghosh A., Dimri M. and Band H. (2004): The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity, 21, 7-17.
    • (2004) Immunity , vol.21 , pp. 7-17
    • Duan, L.1    Reddi, A.L.2    Ghosh, A.3    Dimri, M.4    Band, H.5
  • 10
    • 23144449583 scopus 로고    scopus 로고
    • Delivery of ubiquitinated substrates to protein-unfolding machines
    • Elsasser S. and Finley D. (2005). Delivery of ubiquitinated substrates to protein-unfolding machines. Nat. Cell Biol., 7, 742-710.
    • (2005) Nat. Cell Biol , vol.7 , pp. 742-710
    • Elsasser, S.1    Finley, D.2
  • 11
    • 33646007018 scopus 로고    scopus 로고
    • Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival
    • Furumoto Y., Brooks S., Olivera A., Takagi Y., Miyagishi M., Taira K., Casellas R., Beaven M. A., Gilfillan A. M. and Rivera J. (2006): Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J. Immunol., 176, 5167-5171.
    • (2006) J. Immunol , vol.176 , pp. 5167-5171
    • Furumoto, Y.1    Brooks, S.2    Olivera, A.3    Takagi, Y.4    Miyagishi, M.5    Taira, K.6    Casellas, R.7    Beaven, M.A.8    Gilfillan, A.M.9    Rivera, J.10
  • 12
    • 10344245562 scopus 로고    scopus 로고
    • The FcepsilonRIbeta immunoreceptor tyrosine - based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production
    • Furumoto Y., Nunomura S., Terada T., Rivera J. and Ra C. (2004): The FcepsilonRIbeta immunoreceptor tyrosine - based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. J. Biol. Chem., 279, 49177-49187.
    • (2004) J. Biol. Chem , vol.279 , pp. 49177-49187
    • Furumoto, Y.1    Nunomura, S.2    Terada, T.3    Rivera, J.4    Ra, C.5
  • 14
    • 33751047873 scopus 로고    scopus 로고
    • Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation
    • Gibbs B. F., Rathling A., Zillikens D., Huber M. and Haas H. (2006): Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation. J. Allergy Clin. Immunol., 118, 1060-1067.
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 1060-1067
    • Gibbs, B.F.1    Rathling, A.2    Zillikens, D.3    Huber, M.4    Haas, H.5
  • 15
    • 33344470236 scopus 로고    scopus 로고
    • Integrated pathways for mast-cell activation
    • Gilfillan A. M. and Tkaczyk C. (2006): Integrated pathways for mast-cell activation. Nat. Rev. Immunol., 6, 218-230.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 218-230
    • Gilfillan, A.M.1    Tkaczyk, C.2
  • 16
    • 10844230204 scopus 로고    scopus 로고
    • SHIP down-regulates FcepsilonR1 - induced degranulation at supraoptimal IgE or antigen levels
    • Gimborn K., Lessmann E., Kuppig S., Krystal G. and Huber M. (2005): SHIP down-regulates FcepsilonR1 - induced degranulation at supraoptimal IgE or antigen levels. J. Immunol., 174, 507-516.
    • (2005) J. Immunol , vol.174 , pp. 507-516
    • Gimborn, K.1    Lessmann, E.2    Kuppig, S.3    Krystal, G.4    Huber, M.5
  • 17
    • 28244493479 scopus 로고    scopus 로고
    • Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells
    • Gomez G., Gonzalez-Espinosa C., Odom S., Baez G., Cid M. E., Ryan J. J. and Rivera J. (2005): Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J. Immunol., 175, 7602-7610.
    • (2005) J. Immunol , vol.175 , pp. 7602-7610
    • Gomez, G.1    Gonzalez-Espinosa, C.2    Odom, S.3    Baez, G.4    Cid, M.E.5    Ryan, J.J.6    Rivera, J.7
  • 19
    • 33750327245 scopus 로고    scopus 로고
    • Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells
    • Gustin S. E., Thien C. B. and Langdon W. Y. (2006): Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells. J. Immunol., 177, 5980-5989.
    • (2006) J. Immunol , vol.177 , pp. 5980-5989
    • Gustin, S.E.1    Thien, C.B.2    Langdon, W.Y.3
  • 22
    • 33846908740 scopus 로고    scopus 로고
    • The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation
    • Herzog S. and Jumaa H. (2007): The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation. J. Immunol., 178, 2336-2343.
    • (2007) J. Immunol , vol.178 , pp. 2336-2343
    • Herzog, S.1    Jumaa, H.2
  • 23
    • 0035293622 scopus 로고    scopus 로고
    • Protein regulation by monoubiquitin
    • Hicke L. (2001): Protein regulation by monoubiquitin. Nat. Rev. Mol. Cell Biol., 2, 195-201.
    • (2001) Nat. Rev. Mol. Cell Biol , vol.2 , pp. 195-201
    • Hicke, L.1
  • 24
    • 0032530195 scopus 로고    scopus 로고
    • The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation
    • Huber M., Helgason C. D., Damen J. E., Liu L., Humphries R. K. and Krystal G. (1998): The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc. Natl. Acad. Sci. USA, 95, 11330-13335.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11330-13335
    • Huber, M.1    Helgason, C.D.2    Damen, J.E.3    Liu, L.4    Humphries, R.K.5    Krystal, G.6
  • 25
    • 0036569406 scopus 로고    scopus 로고
    • SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity
    • Kalesnikoff J., Baur N., Leitges M., Hughes M. R., Damen J. E., Huber M. and Krystal G. (2002): SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. J. Immunol., 168, 4737-4746.
    • (2002) J. Immunol , vol.168 , pp. 4737-4746
    • Kalesnikoff, J.1    Baur, N.2    Leitges, M.3    Hughes, M.R.4    Damen, J.E.5    Huber, M.6    Krystal, G.7
  • 26
    • 34249989118 scopus 로고    scopus 로고
    • Roles of RabGEF1/Rabex-5 domains in regulating FcepsilonRI surface expression and FcepsilonRI-dependent responses in mast cells
    • in press
    • Kalesnikoff J., Rios E. J., Chen C. C., Barbieri M. A., Tsai M., Tam S. Y. and Galli S. J. (2007): Roles of RabGEF1/Rabex-5 domains in regulating FcepsilonRI surface expression and FcepsilonRI-dependent responses in mast cells. Blood (in press).
    • (2007) Blood
    • Kalesnikoff, J.1    Rios, E.J.2    Chen, C.C.3    Barbieri, M.A.4    Tsai, M.5    Tam, S.Y.6    Galli, S.J.7
  • 27
    • 0036888570 scopus 로고    scopus 로고
    • Inhibitory receptors and allergy
    • Katz H. R. (2002): Inhibitory receptors and allergy. Curr. Opin. Immunol., 14, 698-704.
    • (2002) Curr. Opin. Immunol , vol.14 , pp. 698-704
    • Katz, H.R.1
  • 29
    • 0030946792 scopus 로고    scopus 로고
    • The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor
    • Kimura T., Sakamoto H., Appella E. and Siraganian R. P. (1997): The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor. J. Biol.Chem., 272, 13991-13996.
    • (1997) J. Biol.Chem , vol.272 , pp. 13991-13996
    • Kimura, T.1    Sakamoto, H.2    Appella, E.3    Siraganian, R.P.4
  • 30
    • 0031279370 scopus 로고    scopus 로고
    • Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor
    • Kimura T., Zhang J., Sagawa K., Sakaguchi K., Appella E. and Siraganian R. P. (1997): Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor. J. Immunol., 159, 4426-4434.
    • (1997) J. Immunol , vol.159 , pp. 4426-4434
    • Kimura, T.1    Zhang, J.2    Sagawa, K.3    Sakaguchi, K.4    Appella, E.5    Siraganian, R.P.6
  • 31
    • 33646673117 scopus 로고    scopus 로고
    • Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness
    • Kovarova M., Wassif C. A., Odom S., Liao K., Porter F. D. and Rivera J. (2006): Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness. J. Exp. Med., 203, 1161-1171.
    • (2006) J. Exp. Med , vol.203 , pp. 1161-1171
    • Kovarova, M.1    Wassif, C.A.2    Odom, S.3    Liao, K.4    Porter, F.D.5    Rivera, J.6
  • 32
    • 0142155218 scopus 로고    scopus 로고
    • Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation
    • Kyo S., Sada K., Qu X., Maeno K., Miah S. M., Kawauchi-Kamata K. and Yamamura H. (2003): Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation. Genes Cells, 8, 825-836.
    • (2003) Genes Cells , vol.8 , pp. 825-836
    • Kyo, S.1    Sada, K.2    Qu, X.3    Maeno, K.4    Miah, S.M.5    Kawauchi-Kamata, K.6    Yamamura, H.7
  • 33
    • 0035853045 scopus 로고    scopus 로고
    • Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling
    • Lafont F. and Simons K. (2001): Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling. Proc. Natl. Acad. Sci. USA, 98, 3180-3184.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 3180-3184
    • Lafont, F.1    Simons, K.2
  • 34
    • 0033553532 scopus 로고    scopus 로고
    • Substrate targeting in the ubiquitin system
    • Laney J. D. and Hochstrasser M. (1999): Substrate targeting in the ubiquitin system. Cell, 97, 427-430.
    • (1999) Cell , vol.97 , pp. 427-430
    • Laney, J.D.1    Hochstrasser, M.2
  • 35
    • 0030604541 scopus 로고    scopus 로고
    • The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma- mediated cell activation signals
    • Lin S., Cicala C., Scharenberg A. M. and Kinet J.-P. (1996): The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma- mediated cell activation signals. Cell, 85, 985-995.
    • (1996) Cell , vol.85 , pp. 985-995
    • Lin, S.1    Cicala, C.2    Scharenberg, A.M.3    Kinet, J.-P.4
  • 36
    • 0016379987 scopus 로고
    • Histamine release: In vitro studies of the inhibitory region of the dose - response curve
    • Magro A. M. and Alexander A. (1974): Histamine release: in vitro studies of the inhibitory region of the dose - response curve. J. Immunol., 112, 1762-1765.
    • (1974) J. Immunol , vol.112 , pp. 1762-1765
    • Magro, A.M.1    Alexander, A.2
  • 38
    • 5044238408 scopus 로고    scopus 로고
    • Mast-cell responses to pathogens
    • Marshall J. S. (2004): Mast-cell responses to pathogens. Nat. Rev. Immunol., 4, 787-799.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 787-799
    • Marshall, J.S.1
  • 39
    • 0026611231 scopus 로고
    • The receptor with high affinity for IgE
    • Metzger H. (1992): The receptor with high affinity for IgE. Immunol. Rev., 125, 37-48.
    • (1992) Immunol. Rev , vol.125 , pp. 37-48
    • Metzger, H.1
  • 41
    • 0027361087 scopus 로고
    • Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals
    • Monteiro R. C., Hostoffer R. W., Cooper M. D., Bonner J. R., Gartland G. L. and Kubagawa H. (1993): Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals. J. Clin. Invest., 92, 1681-1685.
    • (1993) J. Clin. Invest , vol.92 , pp. 1681-1685
    • Monteiro, R.C.1    Hostoffer, R.W.2    Cooper, M.D.3    Bonner, J.R.4    Gartland, G.L.5    Kubagawa, H.6
  • 42
    • 33846471122 scopus 로고    scopus 로고
    • Proteasome-independent functions of ubiquitn in endocytosis and signaling
    • Mukhopadhyay D. and Riezman H. (2007): Proteasome-independent functions of ubiquitn in endocytosis and signaling. Science, 315, 201-205.
    • (2007) Science , vol.315 , pp. 201-205
    • Mukhopadhyay, D.1    Riezman, H.2
  • 43
    • 0033753014 scopus 로고    scopus 로고
    • Signal transduction by the high-affinity immunoglobulin E receptor Fcepsilon RI: Coupling form to function
    • Nadler M. J., Matthews S. A., Turner H. and Kinet J.-P. (2000): Signal transduction by the high-affinity immunoglobulin E receptor Fcepsilon RI: coupling form to function. Adv. Immunol., 76, 325-355.
    • (2000) Adv. Immunol , vol.76 , pp. 325-355
    • Nadler, M.J.1    Matthews, S.A.2    Turner, H.3    Kinet, J.-P.4
  • 45
    • 33845932895 scopus 로고    scopus 로고
    • Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung
    • Oh S. Y., Zheng T., Bailey M. L., Barber D. L., Schroeder J. T., Kim Y. K. and Zhu Z. (2007): Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung. J. Allergy Clin. Immunol., 119, 123-131.
    • (2007) J. Allergy Clin. Immunol , vol.119 , pp. 123-131
    • Oh, S.Y.1    Zheng, T.2    Bailey, M.L.3    Barber, D.L.4    Schroeder, J.T.5    Kim, Y.K.6    Zhu, Z.7
  • 46
    • 0024293527 scopus 로고
    • Possible orientational constraints determine secretory signals induced by aggregation of IgE receptors on mast cells
    • Ortega E., Schweitzer-Stenner R. and Pecht I. (1988): Possible orientational constraints determine secretory signals induced by aggregation of IgE receptors on mast cells. EMBO J., 7, 4101-4109.
    • (1988) EMBO J , vol.7 , pp. 4101-4109
    • Ortega, E.1    Schweitzer-Stenner, R.2    Pecht, I.3
  • 47
    • 0029852837 scopus 로고    scopus 로고
    • Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells
    • Ota Y., Beitz L. O., Scharenberg A. M., Donovan J. A., Kinet J.-P. and Samelson L. E. (1996): Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. J. Exp. Med., 184, 1713-1723.
    • (1996) J. Exp. Med , vol.184 , pp. 1713-1723
    • Ota, Y.1    Beitz, L.O.2    Scharenberg, A.M.3    Donovan, J.A.4    Kinet, J.-P.5    Samelson, L.E.6
  • 48
    • 0030889218 scopus 로고    scopus 로고
    • The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase
    • Ota Y. and Samelson L E. (1997): The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. Science, 276, 418-420.
    • (1997) Science , vol.276 , pp. 418-420
    • Ota, Y.1    Samelson, L.E.2
  • 49
    • 0027458572 scopus 로고
    • Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors
    • Paolini R. and Kinet J.-P. (1993): Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors. EMBO J., 12, 779-786.
    • (1993) EMBO J , vol.12 , pp. 779-786
    • Paolini, R.1    Kinet, J.-P.2
  • 53
    • 0037075606 scopus 로고    scopus 로고
    • The endophilin - CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met
    • Petrelli A., Gilestro G. F., Lanzardo S., Comoglio P. M., Migone N. and Giordano S. (2002): The endophilin - CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature, 416, 187-190.
    • (2002) Nature , vol.416 , pp. 187-190
    • Petrelli, A.1    Gilestro, G.F.2    Lanzardo, S.3    Comoglio, P.M.4    Migone, N.5    Giordano, S.6
  • 54
    • 1442308053 scopus 로고    scopus 로고
    • Negative regulation of FcepsilonRI - mediated mast cell activation by a ubiquitin-protein ligase Cbl-b
    • Qu X., Sada K., Kyo S., Maeno K., Miah S. M. and Yamamura H. (2004): Negative regulation of FcepsilonRI - mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Blood, 103, 1779-1786.
    • (2004) Blood , vol.103 , pp. 1779-1786
    • Qu, X.1    Sada, K.2    Kyo, S.3    Maeno, K.4    Miah, S.M.5    Yamamura, H.6
  • 55
    • 33646933031 scopus 로고    scopus 로고
    • Molecular regulation of mast cell activation
    • Rivera J. and Gilfillan A. M. (2006): Molecular regulation of mast cell activation. J. Allergy Clin. Immunol., 117, 1214-1225.
    • (2006) J. Allergy Clin. Immunol , vol.117 , pp. 1214-1225
    • Rivera, J.1    Gilfillan, A.M.2
  • 56
    • 0022568938 scopus 로고
    • Cross-linking of immunoglobulin E-receptor complexes induces their interaction with the cytoskeleton of rat basophilic leukemia cells
    • Robertson D., Holowka D. and Baird B. (1986): Cross-linking of immunoglobulin E-receptor complexes induces their interaction with the cytoskeleton of rat basophilic leukemia cells. J. Immunol., 136, 4565-4572.
    • (1986) J. Immunol , vol.136 , pp. 4565-4572
    • Robertson, D.1    Holowka, D.2    Baird, B.3
  • 57
    • 32344451150 scopus 로고    scopus 로고
    • Regulating the regulator: Negative regulation of Cbl ubiquitin ligases
    • Ryan P. E., Davies G. C., Nau M. M. and Lipkowitz S. (2006): Regulating the regulator: negative regulation of Cbl ubiquitin ligases. Trends Biochem. Sci., 31, 79-88.
    • (2006) Trends Biochem. Sci , vol.31 , pp. 79-88
    • Ryan, P.E.1    Davies, G.C.2    Nau, M.M.3    Lipkowitz, S.4
  • 58
    • 0042886047 scopus 로고    scopus 로고
    • The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation
    • Saitoh S., Odom S., Gomez G., Sommers C. L., Young H. A., Rivera J. and Samelson L. E. (2003): The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J. Exp. Med., 198, 831-843.
    • (2003) J. Exp. Med , vol.198 , pp. 831-843
    • Saitoh, S.1    Odom, S.2    Gomez, G.3    Sommers, C.L.4    Young, H.A.5    Rivera, J.6    Samelson, L.E.7
  • 59
    • 13544271663 scopus 로고    scopus 로고
    • Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities
    • Schmidt M. H., Dikic I. and Bogler O. (2005): Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. J. Biol. Chem., 280, 3414-3425.
    • (2005) J. Biol. Chem , vol.280 , pp. 3414-3425
    • Schmidt, M.H.1    Dikic, I.2    Bogler, O.3
  • 60
    • 0242659390 scopus 로고    scopus 로고
    • Mast cell signal transduction from the high-affinity IgE receptor
    • Siraganian R. P. (2003): Mast cell signal transduction from the high-affinity IgE receptor. Curr. Opin. Immunol., 15, 639-646.
    • (2003) Curr. Opin. Immunol , vol.15 , pp. 639-646
    • Siraganian, R.P.1
  • 61
    • 0037075547 scopus 로고    scopus 로고
    • Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
    • Soubeyran P., Kowanetz K., Szymkiewicz I., Langdon W. Y. and Dikic I. (2002): Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature, 416, 183-187.
    • (2002) Nature , vol.416 , pp. 183-187
    • Soubeyran, P.1    Kowanetz, K.2    Szymkiewicz, I.3    Langdon, W.Y.4    Dikic, I.5
  • 64
    • 27444445613 scopus 로고    scopus 로고
    • c-Cbl and Cbl-b ubiquitin ligases: Substrate diversity and the negative regulation of signaling responses
    • Thien C. B. and Langdon W. Y. (2005): c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signaling responses. Biochem. J., 391, 153-166.
    • (2005) Biochem. J , vol.391 , pp. 153-166
    • Thien, C.B.1    Langdon, W.Y.2
  • 65
    • 0034602845 scopus 로고    scopus 로고
    • Recognition of the polyubiquitin proteolytic signal
    • Thrower J. S., Hoffman L., Rechsteiner M. and Pickart C. M. (2000): Recognition of the polyubiquitin proteolytic signal. EMBO J., 19, 94-102.
    • (2000) EMBO J , vol.19 , pp. 94-102
    • Thrower, J.S.1    Hoffman, L.2    Rechsteiner, M.3    Pickart, C.M.4
  • 66
    • 3042830452 scopus 로고    scopus 로고
    • NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and FcepsilonRI aggregation
    • Tkaczyk C., Horejsi V., Iwaki S., Draber P., Samelson L. E., Satterthwaite A. B., Nahm D. H., Metcalfe D. D. and Gilfillan A. M. (2004): NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and FcepsilonRI aggregation. Blood, 104, 207-214.
    • (2004) Blood , vol.104 , pp. 207-214
    • Tkaczyk, C.1    Horejsi, V.2    Iwaki, S.3    Draber, P.4    Samelson, L.E.5    Satterthwaite, A.B.6    Nahm, D.H.7    Metcalfe, D.D.8    Gilfillan, A.M.9
  • 67
    • 0032562995 scopus 로고    scopus 로고
    • An unusual mechanism for ligand antagonism
    • Torigoe C., Inman J. K. and Metzger H. (1998): An unusual mechanism for ligand antagonism. Science, 281, 568-572.
    • (1998) Science , vol.281 , pp. 568-572
    • Torigoe, C.1    Inman, J.K.2    Metzger, H.3
  • 69
    • 0035179517 scopus 로고    scopus 로고
    • Src homology 2 domain-containing inositol 5′ phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils
    • Vonakis B. M., Gibbons S. Jr., Sora R., Langdon J. M. and MacDonald S. M. (2001): Src homology 2 domain-containing inositol 5′ phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils. J. Allergy Clin. Immunol., 108, 822-831.
    • (2001) J. Allergy Clin. Immunol , vol.108 , pp. 822-831
    • Vonakis, B.M.1    Gibbons Jr., S.2    Sora, R.3    Langdon, J.M.4    MacDonald, S.M.5
  • 70
    • 0035292759 scopus 로고    scopus 로고
    • Themes and variations on ubiquitylation
    • Weissman A. M. (2001): Themes and variations on ubiquitylation. Nat. Rev. Mol. Cell. Biol., 2, 169-178.
    • (2001) Nat. Rev. Mol. Cell. Biol , vol.2 , pp. 169-178
    • Weissman, A.M.1
  • 72
    • 3242804262 scopus 로고    scopus 로고
    • Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor
    • Zhang J., Chiang Y. J., Hodes R. J. and Siraganian R. P. (2004): Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor. J. Immunol., 173, 1811-1818.
    • (2004) J. Immunol , vol.173 , pp. 1811-1818
    • Zhang, J.1    Chiang, Y.J.2    Hodes, R.J.3    Siraganian, R.P.4
  • 73
    • 0037195902 scopus 로고    scopus 로고
    • Molecular cloning of a novel gene encoding a membrane - associated adaptor protein (LAX) in lymphocyte signaling
    • Zhu M., Janssen E., Leung K. and Zhang W. (2002): Molecular cloning of a novel gene encoding a membrane - associated adaptor protein (LAX) in lymphocyte signaling. J. Biol. Chem., 277, 46151-46158.
    • (2002) J. Biol. Chem , vol.277 , pp. 46151-46158
    • Zhu, M.1    Janssen, E.2    Leung, K.3    Zhang, W.4
  • 74
    • 7244226091 scopus 로고    scopus 로고
    • Positive and negative regulation of FcepsilonRI - mediated signaling by the adaptor protein LAB/NTAL
    • Zhu M., Liu Y., Koonpaew S., Granillo O. and Zhang W. (2004): Positive and negative regulation of FcepsilonRI - mediated signaling by the adaptor protein LAB/NTAL. J. Exp. Med., 200, 991-1000.
    • (2004) J. Exp. Med , vol.200 , pp. 991-1000
    • Zhu, M.1    Liu, Y.2    Koonpaew, S.3    Granillo, O.4    Zhang, W.5
  • 75
    • 33745843997 scopus 로고    scopus 로고
    • Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX
    • Zhu M., Rhee I., Liu Y. and Zhang W. (2006): Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. J. Biol. Chem., 281, 18408-18413.
    • (2006) J. Biol. Chem , vol.281 , pp. 18408-18413
    • Zhu, M.1    Rhee, I.2    Liu, Y.3    Zhang, W.4


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