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Volumn 5, Issue 8, 2004, Pages 844-852

RabGEF1 is a negative regulator of mast cell activation and skin inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN E; LIPID; PROTEIN KINASE; RAS PROTEIN; REGULATOR PROTEIN;

EID: 4444341368     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1093     Document Type: Article
Times cited : (60)

References (50)
  • 1
    • 0026611231 scopus 로고
    • The receptor with high affinity for IgE
    • Metzger, H. The receptor with high affinity for IgE. Immunol. Rev. 125, 37-48 (1992).
    • (1992) Immunol. Rev. , vol.125 , pp. 37-48
    • Metzger, H.1
  • 3
    • 0032970154 scopus 로고    scopus 로고
    • The high-affinity IgE receptor (FcERI): From physiology to pathology
    • Kinet, J.P. The high-affinity IgE receptor (FcERI): from physiology to pathology. Annu. Rev. Immunol. 17, 931-972 (1999).
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 931-972
    • Kinet, J.P.1
  • 5
    • 0033989686 scopus 로고    scopus 로고
    • Mast cells and basophils
    • Galli, S.J. Mast cells and basophils. Curr. Opin. Hematol. 7, 32-39 (2000).
    • (2000) Curr. Opin. Hematol. , vol.7 , pp. 32-39
    • Galli, S.J.1
  • 6
    • 0033965301 scopus 로고    scopus 로고
    • Mast cells in innate immunity
    • Mekori, Y.A. & Metcalfe, D.D. Mast cells in innate immunity. Immunol. Rev. 173, 131-140 (2000).
    • (2000) Immunol. Rev. , vol.173 , pp. 131-140
    • Mekori, Y.A.1    Metcalfe, D.D.2
  • 7
    • 0036888683 scopus 로고    scopus 로고
    • Molecular adapters in FcERI signaling and the allergic response
    • Rivera, J. Molecular adapters in FcERI signaling and the allergic response. Curr. Opin. Immunol. 14, 688-693 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 688-693
    • Rivera, J.1
  • 8
    • 0036780841 scopus 로고    scopus 로고
    • Regulation of mast-cell and basophil function and survival by IgE
    • Kawakami, T. & Galli, S.J. Regulation of mast-cell and basophil function and survival by IgE. Nat. Rev. Immunol. 2, 773-786 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 773-786
    • Kawakami, T.1    Galli, S.J.2
  • 9
    • 0028916595 scopus 로고
    • A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by FcER1 is not shared by a G protein-coupled receptor
    • Hirasawa, N., Scharenberg, A., Yamamura, H., Beaven, M.A. & Kinet, J.P. A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by FcER1 is not shared by a G protein-coupled receptor. J. Biol. Chem. 270, 10960-10967 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 10960-10967
    • Hirasawa, N.1    Scharenberg, A.2    Yamamura, H.3    Beaven, M.A.4    Kinet, J.P.5
  • 10
    • 0029014963 scopus 로고
    • Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules
    • Hirasawa, N., Santini, F. & Beaven, M.A. Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules. J. Immunol. 154, 5391-5402 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 5391-5402
    • Hirasawa, N.1    Santini, F.2    Beaven, M.A.3
  • 11
    • 0030018795 scopus 로고    scopus 로고
    • Syk-dependent phosphorylation of Shc. A potential link between FcERI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2
    • Jabril-Cuenod, B. et al. Syk-dependent phosphorylation of Shc. A potential link between FcERI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2. J. Biol. Chem. 271, 16268-16272 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 16268-16272
    • Jabril-Cuenod, B.1
  • 12
    • 0030457522 scopus 로고    scopus 로고
    • Downstream signals initiated in mast cells by FcERI and other receptors
    • Beaven, M.A. & Baumgartner, R.A. Downstream signals initiated in mast cells by FcERI and other receptors. Curr. Opin. Immunol. 8, 766-772 (1996).
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 766-772
    • Beaven, M.A.1    Baumgartner, R.A.2
  • 13
    • 0242659390 scopus 로고    scopus 로고
    • Mast cell signal transduction from the high-affinity IgE receptor
    • Siraganian, R.P. Mast cell signal transduction from the high-affinity IgE receptor. Curr. Opin. Immunol. 15, 639-646 (2003).
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 639-646
    • Siraganian, R.P.1
  • 14
    • 0042925283 scopus 로고    scopus 로고
    • A Ras activation pathway dependent on Syk phosphorylation of protein kinase C
    • Kawakami, Y. et al. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc. Natl. Acad. Sci. USA 100, 9470-9475 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9470-9475
    • Kawakami, Y.1
  • 15
    • 0031043776 scopus 로고    scopus 로고
    • Signal transduction from multiple Ras effectors
    • Katz, M.E. & McCormick, F. Signal transduction from multiple Ras effectors. Curr. Opin. Genet. Dev. 7, 75-79 (1997).
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 75-79
    • Katz, M.E.1    McCormick, F.2
  • 17
    • 0026601947 scopus 로고
    • Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases
    • Eiseman, E. & Bolen, J.B. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355, 78-80 (1992).
    • (1992) Nature , vol.355 , pp. 78-80
    • Eiseman, E.1    Bolen, J.B.2
  • 18
    • 0028035310 scopus 로고
    • Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation
    • Pribluda, V.S., Pribluda, C. & Metzger, H. Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc. Natl. Acad. Sci. USA 91, 11246-11250 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11246-11250
    • Pribluda, V.S.1    Pribluda, C.2    Metzger, H.3
  • 19
    • 0028244668 scopus 로고
    • Activation of protein tyrosine kinase p72syk by FcERI aggregation in rat basophilic leukemia cells. p72syk is a minor component but the major protein tyrosine kinase of pp72
    • Minoguchi, K. et al. Activation of protein tyrosine kinase p72syk by FcERI aggregation in rat basophilic leukemia cells. p72syk is a minor component but the major protein tyrosine kinase of pp72. J. Biol. Chem. 269, 16902-16908 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 16902-16908
    • Minoguchi, K.1
  • 20
  • 21
    • 0033678973 scopus 로고    scopus 로고
    • LAT is essential for FcERI-mediated mast cell activation
    • Saitoh, S. et al. LAT is essential for FcERI-mediated mast cell activation. Immunity 12, 525-535 (2000).
    • (2000) Immunity , vol.12 , pp. 525-535
    • Saitoh, S.1
  • 22
    • 0036347746 scopus 로고    scopus 로고
    • Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
    • Parravicini, V. et al. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol. 3, 741-748 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 741-748
    • Parravicini, V.1
  • 23
    • 17344377424 scopus 로고    scopus 로고
    • A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function
    • Horiuchi, H. et al. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90, 1149-1159 (1997).
    • (1997) Cell , vol.90 , pp. 1149-1159
    • Horiuchi, H.1
  • 24
    • 0035171352 scopus 로고    scopus 로고
    • Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex
    • Lippe, R., Miaczynska, M., Rybin, V., Runge, A. & Zerial, M. Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. Mol. Biol. Cell 12, 2219-2228 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2219-2228
    • Lippe, R.1    Miaczynska, M.2    Rybin, V.3    Runge, A.4    Zerial, M.5
  • 25
    • 0025771976 scopus 로고
    • Expression of three mammalian cDNAs that interfere with Ras function in Saccharomyces cerevisiae
    • Colicelli, J. et al. Expression of three mammalian cDNAs that interfere with Ras function in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 88, 2913-2917 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2913-2917
    • Colicelli, J.1
  • 26
    • 0029977573 scopus 로고    scopus 로고
    • A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins
    • Burd, C.G., Mustol, P.A., Schu, P.V. & Emr, S.D. A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Mol. Cell. Biol. 16, 2369-2377 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2369-2377
    • Burd, C.G.1    Mustol, P.A.2    Schu, P.V.3    Emr, S.D.4
  • 27
    • 0033591319 scopus 로고    scopus 로고
    • Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport
    • Hama, H., Tall, G.G. & Horazdovsky, B.F. Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J. Biol. Chem. 274, 15284-15291 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 15284-15291
    • Hama, H.1    Tall, G.G.2    Horazdovsky, B.F.3
  • 28
    • 0035408008 scopus 로고    scopus 로고
    • Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1
    • Tall, G.G., Barbieri, M.A., Stahl, RD. & Horazdovsky, B.F. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. Dev. Cell 1, 73-82 (2001).
    • (2001) Dev. Cell , vol.1 , pp. 73-82
    • Tall, G.G.1    Barbieri, M.A.2    Stahl, R.D.3    Horazdovsky, B.F.4
  • 29
    • 0036479314 scopus 로고    scopus 로고
    • A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5
    • Saito, K. et al. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. J. Biol. Chem. 277, 3412-3418 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 3412-3418
    • Saito, K.1
  • 30
    • 0028859266 scopus 로고
    • A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1
    • Han, L. & Colicelli, J. A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. Mol. Cell. Biol. 15, 1318-1323 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1318-1323
    • Han, L.1    Colicelli, J.2
  • 31
    • 0030911355 scopus 로고    scopus 로고
    • Protein binding and signaling properties of RIN1 suggest a unique effector function
    • Han, L. et al. Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc. Natl. Acad. Sci. USA 94, 4954-4959 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4954-4959
    • Han, L.1
  • 32
    • 0036142091 scopus 로고    scopus 로고
    • The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins
    • Wang, Y. et al. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. Mol. Cell. Biol. 22, 916-926 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 916-926
    • Wang, Y.1
  • 33
    • 0030830220 scopus 로고    scopus 로고
    • Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
    • Frost, J.A. et al. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. Embo J. 16, 6426-6438 (1997).
    • (1997) Embo J. , vol.16 , pp. 6426-6438
    • Frost, J.A.1
  • 34
    • 0032511882 scopus 로고    scopus 로고
    • The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
    • King, A.J. et al. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396, 180-183 (1998).
    • (1998) Nature , vol.396 , pp. 180-183
    • King, A.J.1
  • 35
    • 0036333485 scopus 로고    scopus 로고
    • Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
    • Eblen, S.T., Slack, J.K., Weber, M.J. & Catling, A.D. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol. Cell. Biol. 22, 6023-6033 (2002).
    • (2002) Mol. Cell Biol. , vol.22 , pp. 6023-6033
    • Eblen, S.T.1    Slack, J.K.2    Weber, M.J.3    Catling, A.D.4
  • 36
    • 0035796397 scopus 로고    scopus 로고
    • ras and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro
    • ras and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. J. Exp. Med. 194, 57-69 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 57-69
    • Ingram, D.A.1
  • 37
    • 0042858153 scopus 로고    scopus 로고
    • The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis
    • Barbieri, M.A., Kong, C., Chen, P.I., Horazdovsky, B.F. & Stahl, P.D. The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis. J. Biol. Chem. 278, 32027-32036 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 32027-32036
    • Barbieri, M.A.1    Kong, C.2    Chen, P.I.3    Horazdovsky, B.F.4    Stahl, P.D.5
  • 38
    • 0035854367 scopus 로고    scopus 로고
    • Endocytosis and signaling. an inseparable partnership
    • Di Fiore, P.P. & De Camilli, P. Endocytosis and signaling. an inseparable partnership. Cell 106, 1-4 (2001).
    • (2001) Cell , vol.106 , pp. 1-4
    • Di Fiore, P.P.1    De Camilli, P.2
  • 39
    • 0032584602 scopus 로고    scopus 로고
    • Protein kinase B/akt and rab5 mediate Ras activation of endocytosis
    • Barbieri, M.A., Kohn, A.D., Roth, R.A. & Stahl, P.D. Protein kinase B/akt and rab5 mediate Ras activation of endocytosis. J. Biol. Chem. 273, 19367-19370 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 19367-19370
    • Barbieri, M.A.1    Kohn, A.D.2    Roth, R.A.3    Stahl, P.D.4
  • 40
    • 0032562579 scopus 로고    scopus 로고
    • Catalytic domain of the p120 Ras GAP binds to Rab5 and stimulates its GTPase activity
    • Liu, K. & Li, G. Catalytic domain of the p120 Ras GAP binds to Rab5 and stimulates its GTPase activity. J. Biol. Chem. 273, 10087-10090 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 10087-10090
    • Liu, K.1    Li, G.2
  • 41
    • 0342762061 scopus 로고    scopus 로고
    • Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1
    • Afar, D.E. et al. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Immunity 6, 773-782 (1997).
    • (1997) Immunity , vol.6 , pp. 773-782
    • Afar, D.E.1
  • 42
    • 0037321304 scopus 로고    scopus 로고
    • The RAS effector RIN1 modulates the formation of aversive memories
    • Dhaka, A. et al. The RAS effector RIN1 modulates the formation of aversive memories. J. Neurosci. 23, 748-757 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 748-757
    • Dhaka, A.1
  • 43
    • 0033178734 scopus 로고    scopus 로고
    • Cutting edge: Extracellular signal-regulated kinase activates syk: A new potential feedback regulation of FcE receptor signaling
    • Xu, R., Seger, R. & Pecht, I. Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of FcE receptor signaling. J. Immunol. 163, 1110-1114 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 1110-1114
    • Xu, R.1    Seger, R.2    Pecht, I.3
  • 44
    • 0034948480 scopus 로고    scopus 로고
    • Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
    • Kalesnikoff, J. et al. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 14, 801-811 (2001).
    • (2001) Immunity , vol.14 , pp. 801-811
    • Kalesnikoff, J.1
  • 45
    • 0034948713 scopus 로고    scopus 로고
    • Regulation of mast cell survival by IgE
    • Asai, K. et al. Regulation of mast cell survival by IgE. Immunity 14, 791-800 (2001).
    • (2001) Immunity , vol.14 , pp. 791-800
    • Asai, K.1
  • 46
    • 0242331616 scopus 로고    scopus 로고
    • Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcERI
    • Kitaura, J. et al. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcERI. Proc. Natl. Acad. Sci. USA 100, 12911-12916 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12911-12916
    • Kitaura, J.1
  • 47
    • 0030902218 scopus 로고    scopus 로고
    • Differential release of mast cell interleukin-6 via c-kit
    • Gagari, E., Tsai, M., Lantz, C.S., Fox, L.G. & Galli, S.J. Differential release of mast cell interleukin-6 via c-kit. Blood 89, 2654-2663 (1997).
    • (1997) Blood , vol.89 , pp. 2654-2663
    • Gagari, E.1    Tsai, M.2    Lantz, C.S.3    Fox, L.G.4    Galli, S.J.5
  • 48
    • 0023514041 scopus 로고
    • Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor
    • Young, J.D., Liu, C.C., Butler, G., Cohn, Z.A. & Galli, S.J. Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor. Proc. Natl. Acad. Sci. USA 84, 9175-9179 (1987).
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 9175-9179
    • Young, J.D.1    Liu, C.C.2    Butler, G.3    Cohn, Z.A.4    Galli, S.J.5
  • 49
    • 33749101463 scopus 로고    scopus 로고
    • The CI.MC/C57.1(C57) mouse mast cell line is of BALB/c origin and is tumorigenic in BALB/c mice
    • Tsai, M. et al. The CI.MC/C57.1(C57) mouse mast cell line is of BALB/c origin and is tumorigenic in BALB/c mice. FASEB J. 10, A1268 (1996).
    • (1996) FASEB J. , vol.10
    • Tsai, M.1
  • 50
    • 0024789004 scopus 로고
    • Mast cell stimulation by monoclonal antibodies specific for the FcE receptor yields distinct responses of arachidonic acid and leukotriene C4 secretion
    • Ortega, E., Hazan, B., Zor, U. & Pecht, I. Mast cell stimulation by monoclonal antibodies specific for the FcE receptor yields distinct responses of arachidonic acid and leukotriene C4 secretion. Eur. J. Immunol. 19, 2251-2256 (1989).
    • (1989) Eur. J. Immunol. , vol.19 , pp. 2251-2256
    • Ortega, E.1    Hazan, B.2    Zor, U.3    Pecht, I.4


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