NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and FcεRI aggregation

Blood

Volumn 104, Issue 1, 2004, Pages 207-214

  Tkaczyk, Christine ^b   Horejsi, Vaclav ^b   Iwaki, Shoko ^b   Draber, Petr ^b   Samelson, Lawrence E ^b   Satterthwaite, Anne B ^b   Nahm, Dong Ho ^b   Metcalfe, Dean D ^b   Gilfillan, Alasdair M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; FC RECEPTOR; LAT PROTEIN; MONOCLONAL ANTIBODY; NON T CELL ACTIVATION LINKER; NTAL PROTEIN; OLIGONUCLEOTIDE; RNA; SMALL INTERFERING RNA; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MAST CELL; MAST CELL DEGRANULATION; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 3042830452     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-08-2769     Document Type: Article

References (37)

1. Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev. 1997;77:1033-1079.
2. Galli SJ. New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity, Lab Invest. 1990;62:5-33.
3. Galli SJ, Tsai M, Wershill BK. The c-kit receptor, stem cell factor, and mast cells: what each is teaching us about the others. Am J Pathol. 1993;142:965-974.
4. Bischoff SC, Dahinden CA. C-kit ligand: a unique potentiator of mediator release by human lung mast cells. J Exp Med. 1992;175:237-244.
5. Benhamou M, Siraganian R. Protein-tyrosine phosphorylation: an essential early component of FcεRI signalling. Immunol Today. 1992;13:195-201.
6. Welham MJ, Schrader JW. Steel factor-induced tyrosine phosphorylation in murine mast cells: common elements with IL-3 induced signal transduction pathways. J Immunol. 1992;149:2772-2783.
7. Benhamou M, Ryba NJP, Kihara H, et al. Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. J Biol Chem. 1993;268:23318-23324.
8. Jouvin MHE, Adamczewski M, Numerof R, et al. Differential control of the tyrosine kinases lyn and syk by the two signalling chains of the high affinity immunoglobulin E receptor. J Biol Chem. 1994;269:5918-5925.
9. Rivera J. Molecular adapters in Fc(epsilon)RI signaling and the allergic response. Curr Opin Immunol. 2002;14:688-693.
10. Yarden Y, Kuang WJ, Yang-Feng T, et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. Embo J. 1987;6:3341-3351.
11. Majumder S, Brown K, Qiu FH, et al. C-kit protein, a transmembrane kinase: identification in tissues and characterization. Mol Cell Biol. 1988;8:4896-4903.
12. Linnekin D. Early signaling pathways activated by c-kit in hematopoietic cells. Int J Biochem Cell Biol. 1999;31:1053-1074.
13. Tkaczyk C, Metcalfe DD, Gilfillan AM. Determination of protein phosphorylation in FcepsilonRI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditions. J Immunol Met. 2002;268:239-243.
14. Brdicka T, Imrich M, Angelisova P, et al. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med. 2002;196:1617-1626.
15. Janssen E, Zhu M, Zhang W, et al. LAB: a new transmembrane-associated adaptor molecule in B cell activation. Nat Immunol. 2003;4:117-123.
16. + and expresses aminopeptidase N (CD13). Blood. 1999;94:2333-2342.
17. Parravicini V, Gadina M, Kovarova M, et al. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol. 2002;3:741-748.
18. Okayama Y, Kirshenbaum AS, Metcalfe DD. Expression of a functional high-affinity IgG receptor, FcγRI, on human mast cells: up-regulation by IFN-γ. J Immunol. 2000;164:4332-4339.
19. Kawakami Y, Kitaura J, Satterthwaite AB, et al. Redundant and opposing functions of two tyrosine kinases, Btk and lyn, in mast cell activation. J Immunol. 2000;165:1210-1219.
20. Chaves-Dias C, Hundley TR, Gilfillan AM, et al. Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines. J Immunol. 2001;166:6647-6656.
21. Yamashita T, Kairiyama L, Araki M, et al. Evidence for involvement of two isoforms of syk protein-tyrosine kinase in signal transduction through the high affinity IgE receptor on rat basophilic leukemia cells. J Biochem. 1998;123:1199-1207.
22. Minoguchi K, Benhamou M, Swaim WD, et al. Activation of protein tyrosine kinase p72syk by Fc epsilon RI aggregation in rat basophilic leukemia cells: p72syk is a minor component but the major protein tyrosine kinase of pp72. J Biol Chem. 1994;269:16902-16908.
23. Pivniouk VI, Martin TR, Lu-Kuo JM, et al. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999;103:1737-1743.
24. Beaven MA, Baumgartner RA. Downstream signals initiated in mast cells by FcεRI and other receptors. Curr Opin Immunol. 1996;8:766-772.
25. Barker SA, Caldwell KK, Pfeiffer JR, et al. Wortmannin-sensitive phosphorylation, translocation, and activation of PLC-γ1, but not PLC-γ2, in antigen-stimulated RBL-2H3 mast cells. Mol Biol Cell. 1998;6:1145-1158.
26. Hanke JH, Gardner JP, Dow RL, et al. Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor. J Biol Chem. 1996;271:695-701.
27. Oliver JM, Burg DL, Wilson BS, et al. Inhibition of mast cell FcεRI-mediated signaling and effector function by the syk-selective inhibitor, piceatannol. J Biol Chem. 1994;269:29697-29703.
28. Tatton L, Morley JM, Chopra R, et al. The Src-selective inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. J Biol Chem. 2003;278:4847-4853.
29. O'Laughlin-Bunner B, Radosevic N, Taylor ML, et al. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001;98:343-350.
30. Kawakami Y, Yao L, Tashiro M, et al. Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells. J Immunol. 1995;155:3556-3562.
31. Bunnell SC, Diehn M, Yaffe MB, et al. Biochemical interactions integrating Itk with the T cell receptor initiated signaling cascade. J Biol Chem. 2000;275:2219-2230.
32. Ching KA, Grasis JA, Tailor P, et al. TCR/CD3-induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the src homology 2 domain. J Immunol. 2000;165:256-262.
33. Hata D, Kawakami Y, Inagaki N, et al. Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. J Exp Med. 1998;187:1235-1247.
34. Samelson LE. Signal transduction mediated by T cell antigen receptor: the role of adapter proteins. Annu Rev Immunol. 2002;20:371-394.
35. Saitoh S, Odom S, Gomez G, et al. The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J Exp Med. 2003;198:831-843.
36. Saitoh S, Arudchandran R, Manetz TS, et al. LAT is essential for FcεRI-mediated mast cell activation. Immunity. 2000;12:525-535.
37. + human primary erythroid cells from apoptosis. Exp Hemathol. 2001;29:833-841.