Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k-Akt signaling pathway

Cancer Letters

Volumn 255, Issue 1, 2007, Pages 117-126

  Baek, Sang Hyun ^a   Kim, Mi Yeon ^a   Mo, Jung Soon ^a   Ann, Eun Jung ^a   Lee, Kyu Shik ^a   Park, Ji Hye ^a   Kim, Jin Young ^a   Seo, Mi Sun ^a   Choi, Eui Ju ^b   Park, Hee Sae ^a  

^a Chonnam National University   (South Korea)

^b Korea University   (South Korea)

Author keywords

Akt; Cytoplasmic retention; LY294002; Notch intracellular domain; Phosphatidylinositol 3 kinase; RBP Jk; Wortmannin; Zinc

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA GALACTOSIDASE; GLUTATHIONE TRANSFERASE; LUCIFERASE; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT ENZYME; WORTMANNIN; ZINC; ZINC CHLORIDE;

ARTICLE; CELL STRAIN HEK293; CYTOPLASM; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; CELL LINE; CHROMONES; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MORPHOLINES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; ZINC;

EID: 34547652560     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.04.002     Document Type: Article

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