SCOPUS 정보 검색 플랫폼

Volumn , Issue 12, 2007, Pages 1893-1896

Synthesis of new chiral 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazines from α-amino acid derivatives under mild conditions

(5) Mohapatra, Debendra K a Maity, Pradip K a Gonnade, Rajesh G a Chorghade, Mukund S a Gurjar, Mukund K a

a NATIONAL CHEMICAL LABORATORY (India)

Author keywords

amino acid; 1,2,3 triazole; 1,3 dipolar cycloaddition; Click chemistry; Pyrazine

Indexed keywords

4,5,6,7 TETRAHYDRO[1,2,3]TRIAZOLO[1,5-A]PYRAZINE DERIVATIVE; ALPHA AMINO ACID; PYRAZINE DERIVATIVE; SOLVENT; TRIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOSELECTIVITY; EVAPORATION; PURIFICATION; SYNTHESIS;

EID: 34547626838 PISSN: 09365214 EISSN: None Source Type: Journal
DOI: 10.1055/s-2007-984537 Document Type: Article

Times cited : (28)

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- Analytical and Spectral Data Compound 3a: [α] D25 -47.76 (c 1.2, CHCl3, IR (CHCl 3, 3023, 1696, 1497, 1223 cm-1. 1H NMR (200 MHz, CDCl3, δ, 0.92 (d, 3 H, J, 6.6 Hz, 0.99 (d, 3 H, J, 6.5 Hz, 1.50 (s, 9 H, 1.53-1.65 (m, 1 H, 4.22 (dd, 1 H, J, 14.0, 4.5 Hz, 4.33 (m, 2 H, 4.76 (d, 1 H, J, 12.5 Hz, 5.13 (m, 1 H, 7.53 (s, 1 H, 13C NMR (50 MHz, CDCl3, δ, 18.7, 19.5, 26.6, 27.8, 36.1, 46.3, 54.3, 55.6, 80.6, 128.6, 128.9, 153.8. ESI-MS: m/z, 267 [M, H, Anal. Calcd, ) for C 13H22N4O2: C, 58.62; H, 8.33; N, 21.04. Found: C, 58.51; H, 8.47; N, 20.88. Compound 3c: [α] D25 -40.21 (c 1.1, CHCl3, IR (CHCl 3, 2980, 1697, 1395, 1218, 1167 cm-1. 1H NMR 400 MHz, CDCl
- 4: C, 58.52; H, 7.37; N, 34.12. Found: C, 58.37; H, 7.11; N, 33.98.

54
- 34547641524
- X-ray intensity data was collected on Bruker SMART APEX CCD diffractometer with graphite-monochromated (MoKα, 0.71073 Å) radiation at r.t. All the data were corrected for Lorentzian, polarization and absorption effects using Bruker's SAINT and SADABS programs. SHELX-97 (ShelxTL)25 was used for structure solution and full matrix least squares refinement on F2. Hydrogen atoms were included in the refinement as per the riding model
- 2. Hydrogen atoms were included in the refinement as per the riding model.

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56
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- Crystallographic data for the structures in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 633496 for 3i. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK [fax: +44(1223)336033; or e-mail: deposit@ccdc.cam.ac.uk
- Crystallographic data for the structures in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 633496 for 3i. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK [fax: +44(1223)336033; or e-mail: deposit@ccdc.cam.ac.uk].

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