Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 10, 2004, Pages 2401-2405

  Kim, Dae Kee ^a   Kim, Joonseop ^a   Park, Hyun Ju ^b  

^a Ewha Womans University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

2 Pyridinyl 1,2,3 triazoles; ALK5; Inhibitors; TGF 1 type 1 receptor

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ENZYME INHIBITOR; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PYRIDINE DERIVATIVE; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ANALYSIS;

ACTIVIN RECEPTORS, TYPE I; BINDING SITES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROSIS; GENES, REPORTER; HUMANS; LUCIFERASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRIAZOLES;

EID: 1942534588     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.024     Document Type: Article

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