Efficient synthesis of biologically important chiral 2-alkylamino benzoxazinones

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 19, 1997, Pages 2527-2530

  Mohapatra, Debendra K ^a   Datta, Apurba ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BENZOXAZINONE DERIVATIVE; CHYMOTRYPSIN; ENZYME INHIBITOR; SERINE PROTEINASE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030855882     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10010-5     Document Type: Article

References (16)

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12. 2O (5 mmol) in dioxan (5 mL) and the mixture stirred for 4 h. The reaction mixture was then concentrated and the residual oil purified by column chromatography (silica gel, petroleum ether/ethyl acetate) affording the product 5.
13. Pozdnev, V.F. Tetrahedron Lett. 1995, 36, 7115, and references therein.
14. 3) δ 159.6, 151.6, 145.5, 140.1, 136.6, 129.2, 128.6, 127.7, 127.6, 126.3, 117.3, 96.7, 81.7, 80.3, 63.8, 29.6, 28.0, 27.7, 26.5; MS (FAB+) 423 (MH+).
15. For general methods for the synthesis of 2-alkyl/aryl substituted benzoxazinone ring, see : (a) Errede, L.A.; Oien, H.T.; Yarian, D.R. J. Org. Chem. 1977, 42, 12.
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