Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives

Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2003, Pages 542-557

  Ryckebusch, Adina ^a   Deprez Poulain, Rébecca ^a   Maes, Louis ^c   Debreu Fontaine, Marie Ange ^a   Mouray, Elisabeth ^b   Grellier, Philippe ^b   Sergheraert, Christian ^a  

^a UNIV LILLE   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c Tibotec ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; HEMATIN; N1 (7 CHLORO 4 QUINOLYL) 1,4 BIS(3 AMINOPROPYL)PIPERAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG RESISTANCE; DRUG SELECTIVITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SURVIVAL TIME;

ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CHLOROQUINE; DRUG RESISTANCE; FEMALE; HUMANS; MALARIA; MICE; PIPERAZINES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037434539     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020960r     Document Type: Article

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