Optically active antifungal azoles: Synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl} -tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 9, 2004, Pages 2225-2238

  Upadhayaya, Ram Shankar ^a   Sinha, Neelima ^a   Jain, Sanjay ^a   Kishore, Nawal ^a   Chandra, Ramesh ^b   Arora, Sudershan K ^a  

^a LUPIN LIMITED   (India)

^b BUNDELKHAND UNIVERSITY   (India)

Author keywords

Antifungal activity; Chiral synthesis; Tetrazole derivatives; Tetrazole triazole compounds

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 3 [5 [2 (4 BENZYLPIPERAZIN 1 YL)ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 (4 BENZYLPIPERAZIN 1 YL)ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 (4 PHENYLPIPERAZIN 1 YL)ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2 BUTOXYPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2 PYRIDYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2 PYRIDYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2,4 DICHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (2,4 DICHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 1 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [5 [2 [4 (DIPHENYLMETHYL)PIPERAZIN 1 YL]ETHYL]TETRAZOL 2 YL] 1 [1,2,4]TRIAZOL 1 YLBUTAN 2 OL; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; RAVUCONAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORICONAZOLE;

AGAR GEL DIFFUSION; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CHEMICAL REACTION; CONTROLLED STUDY; DILUTION; DRUG SYNTHESIS; FUNGAL STRAIN; FUNGUS CULTURE; ISOMER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; REACTION ANALYSIS;

ANTIFUNGAL AGENTS; AZOLES; FUNGI; MICROBIAL SENSITIVITY TESTS; SPECIES SPECIFICITY; STEREOISOMERISM;

ASPERGILLUS; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS;

EID: 1842787547     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.02.014     Document Type: Article

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