Contribution of the conserved amino acids of the melanocortin-4 receptor in D-[Nle4,Phe7]-α-melanocyte-stimulating hormone binding and signaling

Journal of Biological Chemistry

Volumn 282, Issue 30, 2007, Pages 21712-21719

  Chen, Min ^b   Cai, Minying ^c   Aprahamian, Charles J ^a   Georgeson, Keith E ^a   Hruby, Victor ^c   Harmon, Carroll M ^a   Yang, Yingkui ^a  

^a Kentucky   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; FOOD PRODUCTS; HORMONES; MUTAGENESIS;

BINDING AFFINITY; CHIMERIC RECEPTORS; TRANSMEMBRANE REGIONS (TM);

AMINO ACIDS;

ALPHA INTERMEDIN; ASPARTIC ACID; GLUTAMIC ACID; HISTIDINE; MELANOCORTIN 2 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MEMBRANE PROTEIN; PHENYLALANINE; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SURFACE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

ALPHA-MSH; AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT CHIMERIC PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, MELANOCORTIN, TYPE 4; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 34547608426     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702285200     Document Type: Article

References (34)

1. Kopelman, P. G. (2000) Nature 404, 635-643
2. Flegal, K. M., Carroll, M. D., Ogden, C. L., and Johnson, C. L. (2002) J. Am. Med. Assoc. 288, 1723-1727
3. Allison, D. B., Fontaine, K. R., Manson, J. E., Stevens, J., and VanItallie, T. B. (1999) J. Am. Med. Assoc. 282, 1530-1538
4. Zimmermann-Belsing, T., and Feldt-Rasmussen, U. (2004) Endocrinology 145, 1501-1502
5. Rugg, K. (2004) Nurs. Times 100, 28-30
6. Kowalski, T. J. (2004) Appetite 42, 11-14
7. Damcott, C. M., Moffett, S. P., Feingold, E., Barmada, M. M., Marshall, J. A., Hamman, R. F., and Ferrell, R. E. (2004) Metabolism 53, 303-309
8. Geller, F., Reichwald, K., Dempfle, A., Illig, T., Vollmert, C., Herpertz, S., Siffert, W., Platzer, M., Hess, C., Gudermann, T., Biebermann, H., Wichmann, H. E., Schafer, H., Hinney, A., and Hebebrand, J. (2004) Am. J. Hum. Genet. 74, 572-581
9. Lubrano-Berthelier, C., Cavazos, M., Dubern, B., Shapiro, A., Stunff, C. L., Zhang, S., Picart, F., Govaerts, C., Froguel, P., Bougneres, P., Clement, K., and Vaisse, C. (2003) Ann. N. Y. Acad. Sci. 994, 49-57
10. Farooqi, I. S., Keogh, J. M., Yeo, G. S., Lank, E. J., Cheetham, T., and O'Rahilly, S. (2003) N. Engl. J. Med. 348, 1085-1095
11. Farooqi, I. S., Yeo, G. S., Keogh, J. M., Aminian, S., Jebb, S. A., Butler, G., Cheetham, T., and O'Rahilly, S. (2000) J. Clin. Investig. 106, 271-279
12. Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., Smith, F. J., Campfield, L. A., Burn, P., and Lee, F. (1997) Cell 88, 131-141
13. Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., and Cone, R. D. (1997) Nature 385, 165-168
14. Giraudo, S. Q., Billington, C. J., and Levine, A. S. (1998) Brain Res. 809, 302-306
15. Cone, R. D. (1999) Trends Endocrinol. Metab. 10, 211-216
16. Fisher, S. L., Yagaloff, K. A., and Burn, P. (1999) Int. J. Obes. Relat. Metab Disord. 23, Suppl. 1, 54-58
17. Fong, T. M., Mao, C., MacNeil, T., Kalyani, R., Smith, T., Weinberg, D., Tota, M. R., and Van der Ploeg, L. H. (1997) Biochem. Biophys. Res. Commun. 237, 629-631
18. Ollmann, M. M., Wilson, B. D., Yang, Y. K., Kerns, J. A., Chen, Y., Gantz, I., and Barsh, G. S. (1997) Science 278, 135-138
19. Yang, Y. K., Fong, T. M., Dickinson, C. J., Mao, C., Li, J. Y., Tota, M. R., Mosley, R., Van Der Ploeg, L. H., and Gantz, I. (2000) Biochemistry 39, 14900-14911
20. Yang, Y., Chen, M., Lai, Y., Gantz, I., Georgeson, K. E., and Harmon, C. M. (2002) J. Biol. Chem. 277, 20328-20335
21. Haskell-Luevano, C., Cone, R. D., Monck, E. K., and Wan, Y. P. (2001) Biochemistry 40, 6164-6179
22. Fleck, B. A., Chen, C., Yang, W., Huntley, R., Markison, S., Nickolls, S. A., Foster, A. C., and Hoare, S. R. (2005) Biochemistry 44, 14494-14508
23. Hogan, K., Peluso, S., Gould, S., Parsons, I., Ryan, D., Wu, L., and Visiers, I. (2006) J. Med. Chem. 49, 911-922
24. Pogozheva, I. D., Chai, B. X., Lomize, A. L., Fong, T. M., Weinberg, D. H., Nargund, R. P., Mulholland, M. W., Gantz, I., and Mosberg, H. I. (2005) Biochemistry 44, 11329-11341
25. Yang, Y. K., Ollmann, M. M., Wilson, B. D., Dickinson, C., Yamada, T., Barsh, G. S., and Gantz, I. (1997) Mol. Endocrinol. 11, 274-280
26. Yang, Y. K., Dickinson, C., Lai, Y. M., Li, J. Y., and Gantz, I. (2001) Am. J. Physiol. 281, R1877-R1886
27. Yang, Y. K., Thompson, D. A., Dickinson, C. J., Wilken, J., Barsh, G. S., Kent, S. B., and Gantz, I. (1999) Mol. Endocrinol. 13, 148-155
28. Baldwin, J. M. (1993) EMBO J. 12, 1693-1703
29. Yang, Y. K., Dickinson, C. J., Zeng, Q., Li, J. Y., Thompson, D. A., and Gantz, I. (1999) J. Biol. Chem. 274, 14100-14106
30. Yang, Y., Dickinson, C., Haskell-Luevano, C., and Gantz, I. (1997) J. Biol. Chem. 272, 23000-23010
31. Conrad, D. M., Hanniman, E. A., Watson, C. L., Mader, J. S., and Hoskin, D. W. (2004) J. Cell. Biochem. 92, 387-399
32. Haskell-Luevano, C., Sawyer, T. K., Trumpp-Kallmeyer, S., Bikker, J. A., Humblet, C., Gantz, I., and Hruby, V. J. (1996) Drug Des. Discov. 14, 197-211
33. Mizoue, L. S., Bazan, J. F., Johnson, E. C., and Handel, T. M. (1999) Biochemistry 38, 1402-1414
34. Kristiansen, K. (2004) Pharmacol. Ther. 103, 21-80