-
1
-
-
0036535063
-
The diversity in the vanilloid (TRPV) receptor family of ion channels
-
Gunthorpe, M. J.; Benham, C. D.; Randall, A.; Davis, J. B. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol. Sci. 2002, 23, 183-191.
-
(2002)
Trends Pharmacol. Sci
, vol.23
, pp. 183-191
-
-
Gunthorpe, M.J.1
Benham, C.D.2
Randall, A.3
Davis, J.B.4
-
2
-
-
18244402941
-
A unified nomenclature for the superfamily of TRP cation channels
-
Montell, C.; Birnbaumer, L.; Flockerzi, V.; Bindels, R. J.; Bruford, E. A.; Caterina, M. J.; Clapham, D. E.; Harteneck, C.; Heller, S.; Julius, D.; Kojima, I.; Mori, Y.; Penner, R.; Prawitt, D.; Scharenberg, A. M.; Schultz, G.; Shimizu, N.; Zhu, M. X. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002, 9, 229-231.
-
(2002)
Mol. Cell
, vol.9
, pp. 229-231
-
-
Montell, C.1
Birnbaumer, L.2
Flockerzi, V.3
Bindels, R.J.4
Bruford, E.A.5
Caterina, M.J.6
Clapham, D.E.7
Harteneck, C.8
Heller, S.9
Julius, D.10
Kojima, I.11
Mori, Y.12
Penner, R.13
Prawitt, D.14
Scharenberg, A.M.15
Schultz, G.16
Shimizu, N.17
Zhu, M.X.18
-
3
-
-
0035378510
-
The TRP ion channel family
-
Clapham, D. E.; Runnels, R. W.; Strubing, C. The TRP ion channel family. Nat. Rev. Neurosci. 2001, 2, 387-396.
-
(2001)
Nat. Rev. Neurosci
, vol.2
, pp. 387-396
-
-
Clapham, D.E.1
Runnels, R.W.2
Strubing, C.3
-
4
-
-
0031290449
-
Release of substance P from peripheral sensory nerve terminals
-
White, D. M. Release of substance P from peripheral sensory nerve terminals. J. Peripher. Nerv. Syst. 1997, 2, 191-201.
-
(1997)
J. Peripher. Nerv. Syst
, vol.2
, pp. 191-201
-
-
White, D.M.1
-
5
-
-
0141738818
-
Vanilloid receptors take a TRP beyond the sensory afferent
-
Caterina, M. J. Vanilloid receptors take a TRP beyond the sensory afferent. Pain 2003, 105, 5-9.
-
(2003)
Pain
, vol.105
, pp. 5-9
-
-
Caterina, M.J.1
-
6
-
-
0142090230
-
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM
-
McGaraughty, S.; Chu, K. L.; Bitner, R. S.; Martino, B.; El Kouhen, R.; Han, P.; Nikkei, A. L.; Burgard, E. C.; Faltynek, C. R.; Jarvis, M. F. Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM. J. Neurophysiol. 2003, 90, 2702-2710.
-
(2003)
J. Neurophysiol
, vol.90
, pp. 2702-2710
-
-
McGaraughty, S.1
Chu, K.L.2
Bitner, R.S.3
Martino, B.4
El Kouhen, R.5
Han, P.6
Nikkei, A.L.7
Burgard, E.C.8
Faltynek, C.R.9
Jarvis, M.F.10
-
7
-
-
0033614984
-
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
-
Zygmunt, P. M.; Petersson, J.; Andersson, D. A.; Chuang, H.; Sorgard, M.; Di, M. V.; Julius, D.; Hogestatt, E. D. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999, 400, 452-457.
-
(1999)
Nature
, vol.400
, pp. 452-457
-
-
Zygmunt, P.M.1
Petersson, J.2
Andersson, D.A.3
Chuang, H.4
Sorgard, M.5
Di, M.V.6
Julius, D.7
Hogestatt, E.D.8
-
8
-
-
0033984992
-
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
-
Smart, D.; Gunthorpe, M. J.; Jerman, J. C.; Nasir, S.; Gray, J.; Muir, A. I.; Chambers, J. K.; Randall, A. D.; Davis, J. B. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br. J. Pharmacol. 2000, 129, 227-230.
-
(2000)
Br. J. Pharmacol
, vol.129
, pp. 227-230
-
-
Smart, D.1
Gunthorpe, M.J.2
Jerman, J.C.3
Nasir, S.4
Gray, J.5
Muir, A.I.6
Chambers, J.K.7
Randall, A.D.8
Davis, J.B.9
-
9
-
-
0030777012
-
The capsaicin receptor. A heat-activated ion channel in the pain pathway
-
Caterina, M. J.; Schumacher, M. A.; Tominaga, M.; Rosen, T. A.; Levine, J. D.; Julius, D. The capsaicin receptor. A heat-activated ion channel in the pain pathway. Nature 1997, 389, 816-824.
-
(1997)
Nature
, vol.389
, pp. 816-824
-
-
Caterina, M.J.1
Schumacher, M.A.2
Tominaga, M.3
Rosen, T.A.4
Levine, J.D.5
Julius, D.6
-
10
-
-
0032169804
-
The cloned capsaicin receptor integrates multiple pain producing stimuli
-
Tominaga, M.; Caterina, M. J.; Malmberg, A. B.; Rosen, T. A.; Gilbert, H.; Skinner, K.; Raumann, B. E.; Basbaum, A. I.; Julius, D. The cloned capsaicin receptor integrates multiple pain producing stimuli. Neuron 1998, 21, 531-543.
-
(1998)
Neuron
, vol.21
, pp. 531-543
-
-
Tominaga, M.1
Caterina, M.J.2
Malmberg, A.B.3
Rosen, T.A.4
Gilbert, H.5
Skinner, K.6
Raumann, B.E.7
Basbaum, A.I.8
Julius, D.9
-
11
-
-
0032970173
-
Vanilloid (capsaicin) receptors and mechanisms
-
Szallasi, A.; Blumberg, P. M. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol. Rev. 1999, 51, 159-212.
-
(1999)
Pharmacol. Rev
, vol.51
, pp. 159-212
-
-
Szallasi, A.1
Blumberg, P.M.2
-
12
-
-
0034926291
-
The vanilloid receptor: A molecular gateway to the pain pathway
-
Caterina, M.; Julius, D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 2001, 24, 487-517.
-
(2001)
Annu. Rev. Neurosci
, vol.24
, pp. 487-517
-
-
Caterina, M.1
Julius, D.2
-
13
-
-
0034646740
-
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
-
Caterina, M. J.; Leffler, A.; Malmberg, A. B.; Martin, W. J.; Trafton, J.; Petersen-Zeitz, K. R.; Koltzenburg, M.; Basbaum, A. I.; Julius, D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000, 288, 306-313.
-
(2000)
Science
, vol.288
, pp. 306-313
-
-
Caterina, M.J.1
Leffler, A.2
Malmberg, A.B.3
Martin, W.J.4
Trafton, J.5
Petersen-Zeitz, K.R.6
Koltzenburg, M.7
Basbaum, A.I.8
Julius, D.9
-
14
-
-
0034636441
-
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
-
Davis, J. B.; Gray, J.; Gunthorpe, M. J.; Hatcher, J. P.; Davey, P. T.; Overend, P.; Harries, M. H.; Latcham, J.; Clapham, C.; Atkinson, K.; Hughes, S. A.; Ranee, K.; Grau, E.; Harper, A. J.; Pugh, P. L.; Rogers, D. C.; Bingham, S.; Randall, A.; Sheardown, S. A. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 2000, 405, 183-187.
-
(2000)
Nature
, vol.405
, pp. 183-187
-
-
Davis, J.B.1
Gray, J.2
Gunthorpe, M.J.3
Hatcher, J.P.4
Davey, P.T.5
Overend, P.6
Harries, M.H.7
Latcham, J.8
Clapham, C.9
Atkinson, K.10
Hughes, S.A.11
Ranee, K.12
Grau, E.13
Harper, A.J.14
Pugh, P.L.15
Rogers, D.C.16
Bingham, S.17
Randall, A.18
Sheardown, S.A.19
-
15
-
-
0037215646
-
The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
-
Walker, K. M.; Urban, L.; Medhurst, S. J.; Patel, S.; Panesar, M.; Fox, A. J.; McIntyre, P. The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther. 2003, 304, 56-62.
-
(2003)
J. Pharmacol. Exp. Ther
, vol.304
, pp. 56-62
-
-
Walker, K.M.1
Urban, L.2
Medhurst, S.J.3
Patel, S.4
Panesar, M.5
Fox, A.J.6
McIntyre, P.7
-
16
-
-
13444274350
-
-
Gomtsyan, A.; Bayburt, E. K.; Schmidt, R. G.; Zheng, G. Z.; Perner, R. J.; DiDomenico, S.; Koenig, J. R.; Turner, S.; Jinkerson, T.; Drizin, I.; Hannick, S. M.; Macri, B. S.; McDonald, H. A.; Honore, P.; Wismer, C. T.; Marsh, K. C.; Wetter, J.; Stewart, K. D.; Oie, T.; Jarvis, M. F.; Surowy, C. S.; Faltynek, C. R.; Lee, C.-H. Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. J. Med. Chem. 2005, 48, 744-752.
-
Gomtsyan, A.; Bayburt, E. K.; Schmidt, R. G.; Zheng, G. Z.; Perner, R. J.; DiDomenico, S.; Koenig, J. R.; Turner, S.; Jinkerson, T.; Drizin, I.; Hannick, S. M.; Macri, B. S.; McDonald, H. A.; Honore, P.; Wismer, C. T.; Marsh, K. C.; Wetter, J.; Stewart, K. D.; Oie, T.; Jarvis, M. F.; Surowy, C. S.; Faltynek, C. R.; Lee, C.-H. Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. J. Med. Chem. 2005, 48, 744-752.
-
-
-
-
17
-
-
33646766400
-
Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists
-
Drizin, I.; Gomtsyan, A.; Bayburt, E. K.; Schmidt, R. G.; Zheng, G. Z.; Perner, R. J.; DiDomenico, S.; Koenig, J. R.; Turner, S. C.; Jinkerson, T. K.; Brown, B. S.; Keddy, R. G.; McDonald, H. A.; Honore, P.; Wismer, C. T.; Marsh, K. C.; Wetter, J. M.; Polakowski, J. S.; Segreti, J. A.; Jarvis, M. F.; Faltynek, C. R.; Lee, C.-H. Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists. Bioorg. Med. Chem. 2006, 14, 4740-4749.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 4740-4749
-
-
Drizin, I.1
Gomtsyan, A.2
Bayburt, E.K.3
Schmidt, R.G.4
Zheng, G.Z.5
Perner, R.J.6
DiDomenico, S.7
Koenig, J.R.8
Turner, S.C.9
Jinkerson, T.K.10
Brown, B.S.11
Keddy, R.G.12
McDonald, H.A.13
Honore, P.14
Wismer, C.T.15
Marsh, K.C.16
Wetter, J.M.17
Polakowski, J.S.18
Segreti, J.A.19
Jarvis, M.F.20
Faltynek, C.R.21
Lee, C.-H.22
more..
-
18
-
-
0031794065
-
Predicting the oral bioavailability of 19-nortestosterone progestins in vivo from their metabolic stability in human liver microsomal preparations in vitro
-
Kuhnz, W.; Gieschen, H. Predicting the oral bioavailability of 19-nortestosterone progestins in vivo from their metabolic stability in human liver microsomal preparations in vitro. Drug Metab. Dispos. 1998, 26, 1120-1127.
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 1120-1127
-
-
Kuhnz, W.1
Gieschen, H.2
-
19
-
-
3042642772
-
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains
-
Blizzard, T. A.; DiNinno, F.; Morgan, J. D.; Chen, H. Y.; Wu, J. Y.; Gude, C.; Kim, S.; Chan, W.; Birzin, E. T.; Yang, Y. T.; Pai, L.-Y.; Zhang, Z.; Hayes, E. C.; DaSilva, C. A.; Tang, W.; Rohrer, S. P.; Schaeffer, J. M.; Hammond, M. L. Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains. Bioorg. Med. Chem. Lett. 2004, 14, 3861-3864.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 3861-3864
-
-
Blizzard, T.A.1
DiNinno, F.2
Morgan, J.D.3
Chen, H.Y.4
Wu, J.Y.5
Gude, C.6
Kim, S.7
Chan, W.8
Birzin, E.T.9
Yang, Y.T.10
Pai, L.-Y.11
Zhang, Z.12
Hayes, E.C.13
DaSilva, C.A.14
Tang, W.15
Rohrer, S.P.16
Schaeffer, J.M.17
Hammond, M.L.18
-
20
-
-
0036711339
-
3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats
-
3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain 2002, 99, 11-19.
-
(2002)
Pain
, vol.99
, pp. 11-19
-
-
Honore, P.1
Kage, K.2
Mikusa, J.3
Watt, A.T.4
Johnston, J.F.5
Wyatt, J.R.6
Faltynek, C.R.7
Jarvis, M.F.8
Lynch, K.9
-
21
-
-
0037168683
-
-
Jarvis, M. F.; Burgard, E. C.; McGaraughty, S.; Honore, P.; Lynch, K.; Brennan, T. J.; Subieta, A.; van Biesen, T.; Cartmell, J.; Bianchi, B.; Niforatos, W.; Kage, K.; Yu, H.; Mikusa, J.; Wismer, C. T.; Zhu, C. Z.; Chu, K.; Lee, C.-H.; Stewart, A. O.; Polakowski, J.; Cox, B. F.; Kowaluk, E.; Williams, M.; Sullivan, J.; Faltynek, C. A-317491, a novel potent and selective nonnucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc. Natl. Acad. Sci., U.S.A. 2002, 99, 17179-17184.
-
Jarvis, M. F.; Burgard, E. C.; McGaraughty, S.; Honore, P.; Lynch, K.; Brennan, T. J.; Subieta, A.; van Biesen, T.; Cartmell, J.; Bianchi, B.; Niforatos, W.; Kage, K.; Yu, H.; Mikusa, J.; Wismer, C. T.; Zhu, C. Z.; Chu, K.; Lee, C.-H.; Stewart, A. O.; Polakowski, J.; Cox, B. F.; Kowaluk, E.; Williams, M.; Sullivan, J.; Faltynek, C. A-317491, a novel potent and selective nonnucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc. Natl. Acad. Sci., U.S.A. 2002, 99, 17179-17184.
-
-
-
|