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Volumn 50, Issue 15, 2007, Pages 3651-3660

In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 (AMINO)BENZYL]UREA DERIVATIVE; CAPSAICIN; INDAZOLE DERIVATIVE; ISOQUINOLINE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

EID: 34547593667     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070276i     Document Type: Article
Times cited : (23)

References (21)
  • 1
    • 0036535063 scopus 로고    scopus 로고
    • The diversity in the vanilloid (TRPV) receptor family of ion channels
    • Gunthorpe, M. J.; Benham, C. D.; Randall, A.; Davis, J. B. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol. Sci. 2002, 23, 183-191.
    • (2002) Trends Pharmacol. Sci , vol.23 , pp. 183-191
    • Gunthorpe, M.J.1    Benham, C.D.2    Randall, A.3    Davis, J.B.4
  • 4
    • 0031290449 scopus 로고    scopus 로고
    • Release of substance P from peripheral sensory nerve terminals
    • White, D. M. Release of substance P from peripheral sensory nerve terminals. J. Peripher. Nerv. Syst. 1997, 2, 191-201.
    • (1997) J. Peripher. Nerv. Syst , vol.2 , pp. 191-201
    • White, D.M.1
  • 5
    • 0141738818 scopus 로고    scopus 로고
    • Vanilloid receptors take a TRP beyond the sensory afferent
    • Caterina, M. J. Vanilloid receptors take a TRP beyond the sensory afferent. Pain 2003, 105, 5-9.
    • (2003) Pain , vol.105 , pp. 5-9
    • Caterina, M.J.1
  • 11
    • 0032970173 scopus 로고    scopus 로고
    • Vanilloid (capsaicin) receptors and mechanisms
    • Szallasi, A.; Blumberg, P. M. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol. Rev. 1999, 51, 159-212.
    • (1999) Pharmacol. Rev , vol.51 , pp. 159-212
    • Szallasi, A.1    Blumberg, P.M.2
  • 12
    • 0034926291 scopus 로고    scopus 로고
    • The vanilloid receptor: A molecular gateway to the pain pathway
    • Caterina, M.; Julius, D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 2001, 24, 487-517.
    • (2001) Annu. Rev. Neurosci , vol.24 , pp. 487-517
    • Caterina, M.1    Julius, D.2
  • 15
    • 0037215646 scopus 로고    scopus 로고
    • The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
    • Walker, K. M.; Urban, L.; Medhurst, S. J.; Patel, S.; Panesar, M.; Fox, A. J.; McIntyre, P. The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther. 2003, 304, 56-62.
    • (2003) J. Pharmacol. Exp. Ther , vol.304 , pp. 56-62
    • Walker, K.M.1    Urban, L.2    Medhurst, S.J.3    Patel, S.4    Panesar, M.5    Fox, A.J.6    McIntyre, P.7
  • 16
    • 13444274350 scopus 로고    scopus 로고
    • Gomtsyan, A.; Bayburt, E. K.; Schmidt, R. G.; Zheng, G. Z.; Perner, R. J.; DiDomenico, S.; Koenig, J. R.; Turner, S.; Jinkerson, T.; Drizin, I.; Hannick, S. M.; Macri, B. S.; McDonald, H. A.; Honore, P.; Wismer, C. T.; Marsh, K. C.; Wetter, J.; Stewart, K. D.; Oie, T.; Jarvis, M. F.; Surowy, C. S.; Faltynek, C. R.; Lee, C.-H. Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. J. Med. Chem. 2005, 48, 744-752.
    • Gomtsyan, A.; Bayburt, E. K.; Schmidt, R. G.; Zheng, G. Z.; Perner, R. J.; DiDomenico, S.; Koenig, J. R.; Turner, S.; Jinkerson, T.; Drizin, I.; Hannick, S. M.; Macri, B. S.; McDonald, H. A.; Honore, P.; Wismer, C. T.; Marsh, K. C.; Wetter, J.; Stewart, K. D.; Oie, T.; Jarvis, M. F.; Surowy, C. S.; Faltynek, C. R.; Lee, C.-H. Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. J. Med. Chem. 2005, 48, 744-752.
  • 18
    • 0031794065 scopus 로고    scopus 로고
    • Predicting the oral bioavailability of 19-nortestosterone progestins in vivo from their metabolic stability in human liver microsomal preparations in vitro
    • Kuhnz, W.; Gieschen, H. Predicting the oral bioavailability of 19-nortestosterone progestins in vivo from their metabolic stability in human liver microsomal preparations in vitro. Drug Metab. Dispos. 1998, 26, 1120-1127.
    • (1998) Drug Metab. Dispos , vol.26 , pp. 1120-1127
    • Kuhnz, W.1    Gieschen, H.2
  • 21
    • 0037168683 scopus 로고    scopus 로고
    • Jarvis, M. F.; Burgard, E. C.; McGaraughty, S.; Honore, P.; Lynch, K.; Brennan, T. J.; Subieta, A.; van Biesen, T.; Cartmell, J.; Bianchi, B.; Niforatos, W.; Kage, K.; Yu, H.; Mikusa, J.; Wismer, C. T.; Zhu, C. Z.; Chu, K.; Lee, C.-H.; Stewart, A. O.; Polakowski, J.; Cox, B. F.; Kowaluk, E.; Williams, M.; Sullivan, J.; Faltynek, C. A-317491, a novel potent and selective nonnucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc. Natl. Acad. Sci., U.S.A. 2002, 99, 17179-17184.
    • Jarvis, M. F.; Burgard, E. C.; McGaraughty, S.; Honore, P.; Lynch, K.; Brennan, T. J.; Subieta, A.; van Biesen, T.; Cartmell, J.; Bianchi, B.; Niforatos, W.; Kage, K.; Yu, H.; Mikusa, J.; Wismer, C. T.; Zhu, C. Z.; Chu, K.; Lee, C.-H.; Stewart, A. O.; Polakowski, J.; Cox, B. F.; Kowaluk, E.; Williams, M.; Sullivan, J.; Faltynek, C. A-317491, a novel potent and selective nonnucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc. Natl. Acad. Sci., U.S.A. 2002, 99, 17179-17184.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.