Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a β-lactamase that confers resistance to clinical inhibitors

Biochemistry

Volumn 46, Issue 29, 2007, Pages 8689-8699

  Helfand, Marion S ^a,b,d   Taracila, Magdalena A ^a   Totir, Monica A ^a   Bonomo, Robert A ^a,b   Buynak, John D ^c   Van Den Akker, Focco ^a   Carey, Paul R ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SOUTHERN METHODIST UNIVERSITY   (United States)

^d LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DRUG RESISTANCE; INTERMEDIATES; RAMAN CRYSTALLOGRAPHY;

ANTIBIOTICS; ENZYME INHIBITION; ESCHERICHIA COLI; PATHOGENS; REACTION KINETICS;

BIOCHEMISTRY;

2' GLUTAROXY PENEM SULFONE; AMOXICILLIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CLAVULANIC ACID; ENZYME INHIBITOR; PENEM DERIVATIVE; PROTEIN SHV; PROTEIN TEM; SULBACTAM; SULFONE DERIVATIVE; TAZOBACTAM; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; KLEBSIELLA PNEUMONIAE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; STEADY STATE; WILD TYPE;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; BETA-LACTAMS; CLAVULANIC ACID; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCINE; PENICILLANIC ACID; SERINE; SPECTRUM ANALYSIS, RAMAN; STEREOISOMERISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA;

EID: 34547124820     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700581q     Document Type: Article

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