Following the Reactions of Mechanism-Based Inhibitors with β-Lactamase by Raman Crystallography

Biochemistry

Volumn 42, Issue 46, 2003, Pages 13386-13392

  Helfand, Marion S ^a   Totir, Monica A ^b   Carey, Marianne P ^b   Hujer, Andrea M ^a   Bonomo, Robert A ^a   Carey, Paul R ^b  

^a LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CRYSTALLOGRAPHY; DRUG PRODUCTS; MICROSCOPIC EXAMINATION; SINGLE CRYSTALS; SOLUTIONS;

DEACYLATION; REACTION PATHWAYS;

ENZYME INHIBITION;

BETA LACTAMASE; CLAVULANIC ACID; ENAMINE; ENZYME VARIANT; LACTAM; MEROPENEM; SULBACTAM; TAZOBACTAM;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; CORRELATION ANALYSIS; CRYSTAL; CRYSTALLOGRAPHY; DEACYLATION; DRUG MECHANISM; MICROSCOPE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAMAN CRYSTALLOGRAPHY; REACTION ANALYSIS; SPECIES IDENTIFICATION;

AMINES; AMINO ACID SUBSTITUTION; BETA-LACTAMASES; CLAVULANIC ACID; CRYSTALLIZATION; DEUTERIUM OXIDE; ENZYME INHIBITORS; KINETICS; MICROSCOPY; MODELS, MOLECULAR; PENICILLANIC ACID; RECOMBINANT PROTEINS; SPECTRUM ANALYSIS, RAMAN; SULBACTAM; WATER;

EID: 0345254956     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035716w     Document Type: Article

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