Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser 130 → Gly SHV-1 β-lactamase: Insights into the mechanism of inhibition

Journal of Biological Chemistry

Volumn 279, Issue 19, 2004, Pages 19494-19501

  Pagan Rodriguez, Doritza ^a   Zhou, Xiang ^a   Simmons, Reiko ^a   Bethel, Christopher R ^b   Hujer, Andrea M ^b   Helfand, Marion S ^b   Jin, Zhaoyan ^a   Guo, Baochuan ^a   Anderson, Vernon E ^c   Ng, Lily M ^a   Bonomo, Robert A ^b  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; AMINO ACIDS; BACTERIA; ENZYMES; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR STRUCTURE;

BACTERIA RESISTANCE; INFECTIONS;

BIOCHEMISTRY;

ALDEHYDE; AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CLAVULANIC ACID; GLYCINE; PIPERACILLIN PLUS TAZOBACTAM; SERINE; SHV 1 BETA LACTAMASE; SULBACTAM; SULTAMICILLIN; TAZOBACTAM; TIMENTIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; FRAGMENTATION REACTION; HOSPITAL INFECTION; LIQUID CHROMATOGRAPHY; MASS; NONHUMAN; PRIORITY JOURNAL;

BETA-LACTAMASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCINE; KINETICS; MASS SPECTROMETRY; MODELS, CHEMICAL; PENICILLANIC ACID; SERINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRYPSIN;

BACTERIA (MICROORGANISMS);

EID: 2442520300     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311669200     Document Type: Article

References (28)

1. Bush, K. (2001) Clin. Infect. Dis. 32, 1085-1089
2. Bush, K. (2002) Curr. Opin. Investig. Drugs 3, 1284-1290
3. Bush, K., Jacoby, G. A., and Medeiros, A. A. (1995) Antimicrob. Agents Chemother. 39, 1211-1233
4. Galleni, M., Lamotte-Brasseur, J., Rossolini, G. M., Spencer, J., Dideberg, O., and Frere, J. M. (2001) Antimicrob. Agents Chemother. 45, 660-663
5. Helfand, M. S., and Bonomo, R. A. (2003) Curr. Drug Targets Infect. Disord. 3, 9-23
6. Page, M. G. (2000) Drug Resist. Updat. 3, 109-125
7. Ambler, R. P., Coulson, A. F., Frere, J. M., Ghuysen, J. M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., and Waley, S. G. (1991) Biochem. J. 276, 269-272
8. Hujer, A. M., Hujer, K. M., and Bonomo, R. A. (2001) Biochim. Biophys. Acta 1547, 37-51
9. Vakulenko, S. B., Geryk, B., Kotra, L. P., Mobashery, S., and Lerner, S. A. (1998) Antimicrob. Agents Chemother. 42, 1542-1548
10. Helfand, M. S., Hujer, A. M., Sonnichsen, F. D., and Bonomo, R. A. (2002) J. Biol. Chem. 277, 47719-47723
11. Alonso, R., Gerbaud, G., Galimand, M., and Courvalin, P. (2002) Antimicrob. Agents Chemother. 46, 3627-3629
12. Canica, M. M., Barthelemy, M., Gilly, L., Labia, R., Krishnamoorthy, R., and Paul, G. (1997) Antimicrob. Agents Chemother. 41, 374-378
13. Meroueh, S. O., Roblin, P., Golemi, D., Maveyraud, L., Vakulenko, S. B., Zhang, Y., Samama, J. P., and Mobashery, S. (2002) J. Am. Chem. Soc. 124, 9422-9430
14. Swaren, P., Golemi, D., Cabantous, S., Bulychev, A., Maveyraud, L., Mobashery, S., and Samama, J. P. (1999) Biocbemistry 38, 9570-9576
15. Wang, X., Minasov, G., and Shoichet, B. K. (2002) J. Biol. Chem. 277, 32149-32156
16. Kuzin, A. P., Nukaga, M., Nukaga, Y., Hujer, A. M., Bonomo, R. A., and Knox, J. R. (1999) Biochemistry 38, 5720-5727
17. Kuzin, A. P., Nukaga, M., Nukaga, Y., Hujer, A., Bonomo, R. A., and Knox, J. R. (2001) Biochemistry 40, 1861-1866
18. Saves, I., Burlet-Schiltz, O., Maveyraud, L., Samama, J. P., Prome, J. C., and Masson, J. M. (1995) Biochemistry 34, 11660-11667
19. Aplin, R. T., Baldwin, J. E., Schofield, C. J., and Waley, S. G. (1990) FEBS Lett. 277, 212-214
20. Zervosen, A., Valladares, M. H., Devreese, B., Prosperi-Meys, C., Adolph, H. W., Mercuri, P. S., Vanhove, M., Amicosante, G., van Beeumen, J., Frere, J. M., and Galleni, M. (2001) Eur. J. Biochem. 268, 3840-3850
21. Payne, D. J., Bateson, J. H., Tolson, D., Gasson, B., Khushi, T., Ledent, P., and Frere, J. M. (1996) Biochem. J. 314, 457-461
22. Brown, R. P., Aplin, R. T., and Schofield, C. J. (1996) Biochemistry 24, 12421-12432
23. Saves, I., Burlet-Schiltz, O., Swaren, P., Lefevre, F., Masson, J. M., Prome, J. C., and Samama, J. P. (1995) J. Biol. Chem. 270, 18240-18245
24. Yang, Y., Janota, K., Tabei, K., Huang, N., Siegel, M. M., Lin, Y. I., Rasmussen, B. A., and Shlaes, D. M. (2000) J. Biol. Chem. 275, 26674-26682
25. Imtiaz, U., Billings, E. M., Knox, J. R., and Mobashery, S. (1994) Biochemistry 33, 5728-5738
26. Helfand, M. S., Bethel, C. R., Hujer, A. M., Hujer, K. M., Anderson V. E., and Bonomo, R. A. (2003) J. Biol. Chem. 278, 52724-52729
27. Bonomo, R. A., Liu, J., Chen, Y., Ng, L., Hujer, A. M., and Anderson, V. E. (2001) Biochim. Biophys. Acta 1547, 196-205
28. Helfand, M. S., Totir, M. A., Carey, M. P., Hujer, A. M., Bonomo, R. A., and Carey, P. R. (2003) Bioehemistry, 42, 13386-13392