Inhibitor-resistant class a β-lactamases: Consequences of the ser130-to-gly mutation seen in apo and tazobactam structures of the SHV-1 variant

Biochemistry

Volumn 43, Issue 44, 2004, Pages 14111-14117

  Sun, Tao ^a   Bethel, Christopher R ^b   Bonomo, Robert A ^a   Knox, James R ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; AMINO ACIDS; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME KINETICS; HYDROLYSIS;

CLAVULANIC ACIDS; REACTION INTERMEDIATES; WATER MOLECULES;

ENZYME INHIBITION;

BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CLAVULANIC ACID; GLYCINE; SERINE; TAZOBACTAM;

ACYLATION; ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME CONFORMATION; ENZYME STRUCTURE; HYDRATION; HYDROGEN BOND; HYDROLYSIS; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ALANINE; AMINO ACID SUBSTITUTION; APOENZYMES; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; GLUTAMIC ACID; GLYCINE; HYDROLYSIS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PENICILLANIC ACID; SERINE; VARIATION (GENETICS);

BACTERIA (MICROORGANISMS);

EID: 8344289224     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0487903     Document Type: Article

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