Understanding resistance to β-lactams and β-lactamase inhibitors in the SHV β-lactamase: Lessons from the mutagenesis of Ser-130

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52724-52729

  Helfand, Marion S ^a   Bethel, Christopher R ^a   Hujer, Andrea M ^a   Hujer, Kristine M ^a   Anderson, Vernon E ^b   Bonomo, Robert A ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; AMINO ACIDS; ANTIBIOTICS; DISSOCIATION; ENZYME KINETICS; ESCHERICHIA COLI; MUTAGENESIS;

BACTERIAL RESISTANCE;

ENZYME INHIBITION;

AMPICILLIN; AMPICILLIN PLUS CLAVULANIC ACID; BETA LACTAM DERIVATIVE; BETA LACTAMASE INHIBITOR; BETA LACTAMASE TEM 1; CEFALORIDINE; CLAVULANIC ACID; NITROCEFIN; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SHV 1 BETA LACTAMASE; SHV BETA LACTAMASE; SULBACTAM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MUTATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME INACTIVATION; ESCHERICHIA COLI; KINETICS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; TIME SERIES ANALYSIS;

AMPICILLIN; BETA-LACTAMASES; BETA-LACTAMS; BINDING, COMPETITIVE; CLAVULANIC ACID; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MODELS, CHEMICAL; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; PENICILLANIC ACID; PLASMIDS; SERINE; THERMODYNAMICS; TIME FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0346732273     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306059200     Document Type: Article

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