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Volumn 314, Issue , 2007, Pages 325-340

Harnessing NKT cells for therapeutic applications

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; ANTIGEN; CD1D ANTIGEN; IMMUNOMODULATING AGENT; IMMUNOLOGICAL ADJUVANT;

EID: 34447620649     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-69511-0_13     Document Type: Review
Times cited : (22)

References (71)
  • 2
    • 0347776209 scopus 로고    scopus 로고
    • Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    • Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB (2003) Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 4:1230-1237
    • (2003) Nat Immunol , vol.4 , pp. 1230-1237
    • Brigl, M.1    Bry, L.2    Kent, S.C.3    Gumperz, J.E.4    Brenner, M.B.5
  • 3
    • 33644872062 scopus 로고    scopus 로고
    • The natural killer Tlymphocyte: A player in the complex regulation of autoimmune diabetes in non-obese diabetic mice
    • Cardell SL (2006) The natural killer Tlymphocyte: a player in the complex regulation of autoimmune diabetes in non-obese diabetic mice. Clin Exp Immunol 143:194-202
    • (2006) Clin Exp Immunol , vol.143 , pp. 194-202
    • Cardell, S.L.1
  • 4
    • 0032729476 scopus 로고    scopus 로고
    • Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
    • Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y, Bendelac A (1999) Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 163:4647-4650
    • (1999) J Immunol , vol.163 , pp. 4647-4650
    • Carnaud, C.1    Lee, D.2    Donnars, O.3    Park, S.H.4    Beavis, A.5    Koezuka, Y.6    Bendelac, A.7
  • 5
    • 20844451391 scopus 로고    scopus 로고
    • Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients
    • Chang DH, Osman K, Connolly J, Kukreja A, Krasovsky J, Pack M, Hutchinson A, Geller M, Liu N, Annable R et al (2005) Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients. J Exp Med 201:1503-1517
    • (2005) J Exp Med , vol.201 , pp. 1503-1517
    • Chang, D.H.1    Osman, K.2    Connolly, J.3    Kukreja, A.4    Krasovsky, J.5    Pack, M.6    Hutchinson, A.7    Geller, M.8    Liu, N.9    Annable, R.10
  • 8
    • 4644327015 scopus 로고    scopus 로고
    • NKT cell ligand alpha-galactosylceramide blocks the induction of oral tolerance by triggering dendritic cell maturation
    • Chung Y, Chang WS, Kim S, Kang CY (2004) NKT cell ligand alpha-galactosylceramide blocks the induction of oral tolerance by triggering dendritic cell maturation. Eur J Immunol 34:2471-2479
    • (2004) Eur J Immunol , vol.34 , pp. 2471-2479
    • Chung, Y.1    Chang, W.S.2    Kim, S.3    Kang, C.Y.4
  • 11
    • 23244456102 scopus 로고    scopus 로고
    • DNA vaccines: Progress and challenges
    • Donnelly JJ, Wahren B, Liu MA (2005) DNA vaccines: progress and challenges. J Immunol 175:633-639
    • (2005) J Immunol , vol.175 , pp. 633-639
    • Donnelly, J.J.1    Wahren, B.2    Liu, M.A.3
  • 12
    • 33644836341 scopus 로고    scopus 로고
    • Mechanisms of immunopathology inmurine models of central nervous system demyelinating disease
    • Ercolini AM, Miller SD (2006) Mechanisms of immunopathology inmurine models of central nervous system demyelinating disease. J Immunol 176:3293-3298
    • (2006) J Immunol , vol.176 , pp. 3293-3298
    • Ercolini, A.M.1    Miller, S.D.2
  • 13
    • 0035889883 scopus 로고    scopus 로고
    • A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses
    • Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP (2001) A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol 167:5531-5534
    • (2001) J Immunol , vol.167 , pp. 5531-5534
    • Exley, M.A.1    Tahir, S.M.2    Cheng, O.3    Shaulov, A.4    Joyce, R.5    Avigan, D.6    Sackstein, R.7    Balk, S.P.8
  • 14
    • 0036735859 scopus 로고    scopus 로고
    • Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs
    • Fujii S, Shimizu K, Kronenberg M, Steinman RM (2002) Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat Immunol 3:867-874
    • (2002) Nat Immunol , vol.3 , pp. 867-874
    • Fujii, S.1    Shimizu, K.2    Kronenberg, M.3    Steinman, R.M.4
  • 15
    • 0037787982 scopus 로고    scopus 로고
    • Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8. T cell immunity to a coadministered protein
    • Fujii S, Shimizu K, Smith C, Bonifaz L, Steinman RM (2003) Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8. T cell immunity to a coadministered protein. J Exp Med 198:267-279
    • (2003) J Exp Med , vol.198 , pp. 267-279
    • Fujii, S.1    Shimizu, K.2    Smith, C.3    Bonifaz, L.4    Steinman, R.M.5
  • 16
    • 3042545974 scopus 로고    scopus 로고
    • The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
    • Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM (2004) The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med 199:1607-1618
    • (2004) J Exp Med , vol.199 , pp. 1607-1618
    • Fujii, S.1    Liu, K.2    Smith, C.3    Bonito, A.J.4    Steinman, R.M.5
  • 17
    • 0036591697 scopus 로고    scopus 로고
    • Valpha24-JalphaQ- independent CD1d-restricted recognition of alpha-galactosylceramide by human CD4(+) and CD8alphabeta(+) T lymphocytes
    • Gadola SD, Dulphy N, Salio M, Cerundolo V (2002) Valpha24-JalphaQ- independent CD1d-restricted recognition of alpha-galactosylceramide by human CD4(+) and CD8alphabeta(+) T lymphocytes. J Immunol 168:5514-5520
    • (2002) J Immunol , vol.168 , pp. 5514-5520
    • Gadola, S.D.1    Dulphy, N.2    Salio, M.3    Cerundolo, V.4
  • 20
    • 0036896332 scopus 로고    scopus 로고
    • A phase I study of the natural killer T-cell ligand alpha-galactosylceramide in patients with solid tumors
    • Giaccone G (2002) A phase I study of the natural killer T-cell ligand alpha-galactosylceramide in patients with solid tumors. Clin Cancer Res 8:3702-3709
    • (2002) Clin Cancer Res , vol.8 , pp. 3702-3709
    • Giaccone, G.1
  • 21
    • 10044286529 scopus 로고    scopus 로고
    • Going both ways: Immune regulation via CD1d-dependent NKT cells
    • Godfrey DI, Kronenberg M (2004) Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 114:1379-1388
    • (2004) J Clin Invest , vol.114 , pp. 1379-1388
    • Godfrey, D.I.1    Kronenberg, M.2
  • 23
    • 0037018101 scopus 로고    scopus 로고
    • Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining
    • Gumperz JE, Miyake S, Yamamura T, Brenner MB (2002) Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 195:625-636
    • (2002) J Exp Med , vol.195 , pp. 625-636
    • Gumperz, J.E.1    Miyake, S.2    Yamamura, T.3    Brenner, M.B.4
  • 25
    • 10844271455 scopus 로고    scopus 로고
    • Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells
    • Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T (2005) Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. J Immunol 174:551-556
    • (2005) J Immunol , vol.174 , pp. 551-556
    • Hashimoto, D.1    Asakura, S.2    Miyake, S.3    Yamamura, T.4    Van Kaer, L.5    Liu, C.6    Tanimoto, M.7    Teshima, T.8
  • 26
    • 0034970326 scopus 로고    scopus 로고
    • Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide
    • Hayakawa Y, Takeda K, Yagita H, Kakuta S, Iwakura Y, Van Kaer L, Saiki I, Okumura K (2001) Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur J Immunol 31:1720-1727
    • (2001) Eur J Immunol , vol.31 , pp. 1720-1727
    • Hayakawa, Y.1    Takeda, K.2    Yagita, H.3    Kakuta, S.4    Iwakura, Y.5    Van Kaer, L.6    Saiki, I.7    Okumura, K.8
  • 29
    • 1842682026 scopus 로고    scopus 로고
    • Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide
    • Jahng A, Maricic I, Aguilera C, Cardell S, Halder RC, Kumar V (2004) Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J Exp Med 199:947-957
    • (2004) J Exp Med , vol.199 , pp. 947-957
    • Jahng, A.1    Maricic, I.2    Aguilera, C.3    Cardell, S.4    Halder, R.C.5    Kumar, V.6
  • 30
    • 0036660185 scopus 로고    scopus 로고
    • Trafficking machinery of NKT cells: Shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity
    • Kim CH, Johnston B, Butcher EC (2002) Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood 100:11-16
    • (2002) Blood , vol.100 , pp. 11-16
    • Kim, C.H.1    Johnston, B.2    Butcher, E.C.3
  • 33
    • 23844523426 scopus 로고    scopus 로고
    • Alpha-galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor
    • Ko SY, Ko HJ, Chang WS, Park SH, Kweon MN, Kang CY (2005) Alpha-galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor. J Immunol 175:3309-3317
    • (2005) J Immunol , vol.175 , pp. 3309-3317
    • Ko, S.Y.1    Ko, H.J.2    Chang, W.S.3    Park, S.H.4    Kweon, M.N.5    Kang, C.Y.6
  • 36
    • 0037018108 scopus 로고    scopus 로고
    • Distinct functional lineages of human V(alpha)24 natural killer T cells
    • Lee PT, Benlagha K, Teyton L, Bendelac A (2002) Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med 195:637-641
    • (2002) J Exp Med , vol.195 , pp. 637-641
    • Lee, P.T.1    Benlagha, K.2    Teyton, L.3    Bendelac, A.4
  • 40
    • 23644432847 scopus 로고    scopus 로고
    • Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases
    • Miyake S, Yamamura T (2005) Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases. Curr Drug Targets Immune Endocr Metabol Disord 5:315-322
    • (2005) Curr Drug Targets Immune Endocr Metabol Disord , vol.5 , pp. 315-322
    • Miyake, S.1    Yamamura, T.2
  • 41
    • 0035807302 scopus 로고    scopus 로고
    • A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells
    • Miyamoto K, Miyake S, Yamamura T (2001) A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413:531-534
    • (2001) Nature , vol.413 , pp. 531-534
    • Miyamoto, K.1    Miyake, S.2    Yamamura, T.3
  • 44
    • 0942276861 scopus 로고    scopus 로고
    • Therapeutic activation of Valpha24+Vbeta11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity
    • Nieda M, Okai M, Tazbirkova A, Lin H, Yamaura A, Ide K, Abraham R, Juji T, Macfarlane DJ, Nicol AJ (2004) Therapeutic activation of Valpha24+Vbeta11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity. Blood 103:383-389
    • (2004) Blood , vol.103 , pp. 383-389
    • Nieda, M.1    Okai, M.2    Tazbirkova, A.3    Lin, H.4    Yamaura, A.5    Ide, K.6    Abraham, R.7    Juji, T.8    Macfarlane, D.J.9    Nicol, A.J.10
  • 45
    • 2942739333 scopus 로고    scopus 로고
    • The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
    • Oki S, Chiba A, Yamamura T, Miyake S (2004) The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest 113:1631-1640
    • (2004) J Clin Invest , vol.113 , pp. 1631-1640
    • Oki, S.1    Chiba, A.2    Yamamura, T.3    Miyake, S.4
  • 46
    • 0033939943 scopus 로고    scopus 로고
    • Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide
    • Osman Y, Kawamura T, Naito T, Takeda K, Van Kaer L, Okumura K, Abo T (2000) Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur J Immunol 30:1919-1928
    • (2000) Eur J Immunol , vol.30 , pp. 1919-1928
    • Osman, Y.1    Kawamura, T.2    Naito, T.3    Takeda, K.4    Van Kaer, L.5    Okumura, K.6    Abo, T.7
  • 48
    • 0032971371 scopus 로고    scopus 로고
    • The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids
    • Porcelli SA, Modlin RL (1999) The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 17:297-329
    • (1999) Annu Rev Immunol , vol.17 , pp. 297-329
    • Porcelli, S.A.1    Modlin, R.L.2
  • 49
    • 0742272509 scopus 로고    scopus 로고
    • Reis e Sousa C (2004) Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 16:27-34
    • Reis e Sousa C (2004) Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 16:27-34
  • 51
    • 0033697454 scopus 로고    scopus 로고
    • Schulz O, Edwards AD, Schito M, Aliberti J, Manickasingham S, Sher A, Reis e Sousa C (2000) CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453-462
    • Schulz O, Edwards AD, Schito M, Aliberti J, Manickasingham S, Sher A, Reis e Sousa C (2000) CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453-462
  • 52
    • 29144497339 scopus 로고    scopus 로고
    • Functionally distinct NKT cell subsets and subtypes
    • Seino K, Taniguchi M (2005) Functionally distinct NKT cell subsets and subtypes. J Exp Med 202:1623-1626
    • (2005) J Exp Med , vol.202 , pp. 1623-1626
    • Seino, K.1    Taniguchi, M.2
  • 54
    • 10344234206 scopus 로고    scopus 로고
    • Recombinant modified vaccinia Ankara primes functionally activated CTL specific for amelanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence
    • Smith CL, Dunbar PR, Mirza F, Palmowski MJ, Shepherd D, Gilbert SC, Coulie P, Schneider J, Hoffman E, Hawkins R et al (2005a) Recombinant modified vaccinia Ankara primes functionally activated CTL specific for amelanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence. Int J Cancer 113:259-266
    • (2005) Int J Cancer , vol.113 , pp. 259-266
    • Smith, C.L.1    Dunbar, P.R.2    Mirza, F.3    Palmowski, M.J.4    Shepherd, D.5    Gilbert, S.C.6    Coulie, P.7    Schneider, J.8    Hoffman, E.9    Hawkins, R.10
  • 56
    • 0037082487 scopus 로고    scopus 로고
    • Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alphagalactosylceramide
    • Smyth MJ, Crowe NY, Pellicci DG, Kyparissoudis K, Kelly JM, Takeda K, Yagita H, Godfrey DI (2002) Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alphagalactosylceramide. Blood 99:1259-1266
    • (2002) Blood , vol.99 , pp. 1259-1266
    • Smyth, M.J.1    Crowe, N.Y.2    Pellicci, D.G.3    Kyparissoudis, K.4    Kelly, J.M.5    Takeda, K.6    Yagita, H.7    Godfrey, D.I.8
  • 57
    • 3042731121 scopus 로고    scopus 로고
    • The pathogenesis of diabetes in the NOD mouse
    • Solomon M, Sarvetnick N (2004) The pathogenesis of diabetes in the NOD mouse. Adv Immunol 84:239-264
    • (2004) Adv Immunol , vol.84 , pp. 239-264
    • Solomon, M.1    Sarvetnick, N.2
  • 58
    • 17744402087 scopus 로고    scopus 로고
    • Sporri R, Reis e Sousa C (2003) Newly activated T cells promote maturation of bystander dendritic cells but not IL-12 production. J Immunol 171:6406-6413
    • Sporri R, Reis e Sousa C (2003) Newly activated T cells promote maturation of bystander dendritic cells but not IL-12 production. J Immunol 171:6406-6413
  • 59
    • 13944260898 scopus 로고    scopus 로고
    • Sporri R, Reis e Sousa C (2005) Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol 6:163-170
    • Sporri R, Reis e Sousa C (2005) Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol 6:163-170
  • 60
    • 0037371115 scopus 로고    scopus 로고
    • NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo
    • Stober D, Jomantaite I, Schirmbeck R, Reimann J (2003) NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo. J Immunol 170:2540-2548
    • (2003) J Immunol , vol.170 , pp. 2540-2548
    • Stober, D.1    Jomantaite, I.2    Schirmbeck, R.3    Reimann, J.4
  • 61
    • 10744220561 scopus 로고    scopus 로고
    • Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: Abrogation prevents tumor recurrence
    • Terabe M, Matsui S, Park JM, Mamura M, Noben-Trauth N, Donaldson DD, Chen W, Wahl SM, Ledbetter S, Pratt B et al (2003) Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J Exp Med 198:1741-1752
    • (2003) J Exp Med , vol.198 , pp. 1741-1752
    • Terabe, M.1    Matsui, S.2    Park, J.M.3    Mamura, M.4    Noben-Trauth, N.5    Donaldson, D.D.6    Chen, W.7    Wahl, S.M.8    Ledbetter, S.9    Pratt, B.10
  • 62
    • 0742321750 scopus 로고    scopus 로고
    • Role of IL-13 in regulation of anti-tumor immunity and tumor growth
    • Terabe M, Park JM, Berzofsky JA (2004) Role of IL-13 in regulation of anti-tumor immunity and tumor growth. Cancer Immunol Immunother 53:79-85
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 79-85
    • Terabe, M.1    Park, J.M.2    Berzofsky, J.A.3
  • 65
    • 11244304412 scopus 로고    scopus 로고
    • Alpha-galactosylceramide therapy for autoimmune diseases: Prospects and obstacles
    • Van Kaer L (2005) Alpha-galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat Rev Immunol 5:31-42
    • (2005) Nat Rev Immunol , vol.5 , pp. 31-42
    • Van Kaer, L.1
  • 69


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