NKT cell ligand α-galactosylceramide blocks the induction of oral tolerance by triggering dendritic cell maturation

European Journal of Immunology

Volumn 34, Issue 9, 2004, Pages 2471-2479

  Chung, Yeonseok ^a   Chang, Woo Sung ^a   Kim, Sanghee ^a   Kang, Chang Yuil ^a  

^a Seoul National University   (South Korea)

Author keywords

galactosylceramide; Costimulation; Dendritic cell; NKT cell; Oral tolerance

Indexed keywords

1 O (ALPHA GALACTOPYRANOSYL) 2 HEXACOSANOYLAMINO 1,3,4 OCTADECANETRIOL; ALPHA GALACTOSYLCERAMIDE; B7 ANTIGEN; CD86 ANTIGEN; OVALBUMIN; GALACTOSYLCERAMIDE;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DOSE RESPONSE; DRUG MECHANISM; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MESENTERY LYMPH NODE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; ORAL DRUG ADMINISTRATION; PHYSIOLOGY;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD80; DENDRITIC CELLS; FEMALE; GALACTOSYLCERAMIDES; IMMUNE TOLERANCE; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; OVALBUMIN;

EID: 4644327015     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425027     Document Type: Article

References (37)

1. Bendelac, A. and Medzhitov, R., Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J. Exp. Med. 2002. 195: F19-23.
2. Crowe, N. Y., Uldrich, A. P., Kyparissoudis, K., Hammond, K. J., Hayakawa, Y., Sidobre, S., Keating, R., Kronenberg, M., Smyth, M. J. and Godfrey, D. I., Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J. Immunol. 2003. 171: 4020-4027.
3. Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., Koseki, H. and Taniguchi, M., CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 1997. 278: 1626-1629.
4. Fujii, S., Shimizu, K., Smith, C., Bonifaz, L. and Steinman, R. M., Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J. Exp. Med. 2003. 198: 267-279.
5. Kitamura, H., Iwakabe, K., Yahata, T., Nishimura, S., Ohta, A., Ohmi, Y., Sato, M., Takeda, K., Okumura, K., Van Kaer, L., Kawano, T., Taniguchi, M. and Nishimura, T., The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 1999. 189: 1121-1128.
6. Hansen, D. S., Siomos, M. A., Buckingham, L., Scalzo, A. A. and Schofield, L., Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 2003. 18: 391-402.
7. Gonzalez-Aseguinolaza, G., Van Kaer, L., Bergmann, C. C., Wilson, J. M., Schmieg, J., Kronenberg, M., Nakayama, T., Taniguchi, M., Koezuka, Y. and Tsuji, M., Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 2002. 195: 617-624.
8. Moodycliffe, A. M., Nghiem, D., Clydesdale, G. and Ullrich, S. E., Immune suppression and skin cancer development: regulation by NKT cells. Nat. Immunol. 2000. 1: 521-525.
9. Wang, B., Geng, Y. B. and Wang, C. R., CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 2001. 194: 313-320.
10. Hong, S., Wilson, M. T., Serizawa, I., Wu, L., Singh, N., Naidenko, O. V., Miura, T., Haba, T., Scherer, D. C., Wei, J., Kronenberg, M., Koezuka, Y. and Van Kaer, L., The natural killer T cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 2001. 7: 1052-1056.
11. Naumov, Y. N., Bahjat, K. S., Gausling, R., Abraham, R., Exley, M. A., Koezuka, Y., Balk, S. B., Strominger, J. L., Clare-Salzer, M. and Wilson, S. B., Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc. Natl. Acad. Sci. USA 2001. 98: 13838-13843.
12. Miyamoto, K., Miyake, S. and Yamamura, T., A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001. 413: 531-534.
13. Terabe, M., Matsui, S., Noben-Trauth, N., Chen, H., Watson, C., Donaldson, D. D., Carbone, D. P., Paul, W. E. and Berzofsky, J. A., NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat. Immunol. 2000. 1: 515-520.
14. Seino, K. I., Fukao, K., Muramoto, K., Yanagisawa, K., Takada, Y., Kakuta, S., Iwakura, Y., Van Kaer, L., Takeda, K., Nakayama, T., Taniguchi, M., Bashuda, H., Yagita, H. and Okumura, K., Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 2001. 98: 2577-2581.
15. Ikehara, Y., Yasunami, Y., Kodama, S., Maki, T., Nakano, M., Nakayama, T., Taniguchi, M. and Ikeda, S., CD4(+) Valpha14 natural killer T cells are essential for acceptance of rat islet xenografts in mice. J. Clin. Invest. 2000. 105: 1761-1767.
16. Sonoda, K. H., Exley, M., Snapper, S., Balk, S. P. and Stein-Streilein, J., CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 1999. 190: 1215-1226.
17. Nakamura, T., Sonoda, K. H., Faunce, D. E., Gumperz, J., Yamamura, T., Miyake, S. and Stein-Streilein, J., CD4(+) NKT cells, but not conventional CD4(+) T cells, are required to generate efferent CD8(+) T regulatory cells following antigen inoculation in an immune-privileged site. J. Immunol. 2003. 171: 1266-1271.
18. Wilson, S. B. and Delovitch, T. L., Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity. Nat. Rev. Immunol. 2003. 3: 211-222.
19. Weiner, H. L., Mackin, G. A., Matsui, M., Orav, E. J., Khoury, S. J., Dawson, D. M. and Hafler, D. A., Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 1993. 259: 1321-1324.
20. Weiner, H. L., Friedman, A., Miller, A., Khoury, S. J., al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R. B., Trentham, D. E. and Hafler, D. A., Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 1994. 12: 809-837.
21. Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A. and Weiner, H. L., Effects of oral administration of type II collagen on rheumatoid arthritis. Science 1993. 261: 1727-1730.
22. Chung, Y., Cho, J., Chang, Y. S., Cho, S. H. and Kang, C. Y., Preventive and therapeutic effects of oral tolerance in a murine model of asthma. Immunobiology 2002. 206: 408-423.
23. Williamson, E., Westrich, G. M. and Viney, J. L., Modulating dendritic cells to optimize mucosal immunization protocols. J. Immunol. 1999. 163: 3668-3675.
24. Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J. V., Steinman, R. M. and Nussenzweig, M. C., Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 2001. 194: 769-779.
25. Legge, K. L., Gregg, R. K., Maldonado-Lopez, R., Li, L., Caprio, J. C., Moser, M. and Zaghouani, H., On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity. J. Exp. Med. 2002. 196: 217-227.
26. Chung, Y., Kim, D. H., Lee, S. H. and Kang, C. Y., Co-administration of CD40 agonistic antibody and antigen fails to overcome the induction of oral tolerance. Immunology 2004. 111: 19-26.
27. + T cell tolerance to soluble antigens. Immunol. Lett. 2002. 84: 125-132.
28. + T cells. J. Immunol. 2000. 164: 2890-2896.
29. + T cells in vivo. J. Immunol. 2003. 170: 2540-2548.
30. Wilson, M. T., Johansson, C., Olivares-Villagomez, D., Singh, A. K., Stanic, A. K., Wang, C. R., Joyce, S., Wick, M. J. and Van Kaer, L., The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc. Natl. Acad. Sci. USA 2003. 100: 10913-10918.
31. Ishimitsu, R., Yajima, T., Nishimura, H., Kawauchi, H. and Yoshikai, Y., NKT cells are dispensable in the induction of oral tolerance but are indispensable in the abrogation of oral tolerance by prostaglandin E. Eur. J. Immunol. 2003. 33: 183-193.
32. Zhang, X., Izikson, L., Liu, L. and Weiner, H. L., Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J. Immunol. 2001. 167: 4245-4253.
33. + mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application. Eur. J. Immunol. 2003. 33: 2801-2810.
34. + T cells in a TH2 response and in immunoglobulin E production. Science 1995. 270: 1845-1847.
35. + T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. USA 1995. 92: 11931-11934.
36. Takikawa, H., Muto, S.-E. and Mori, K., Diastereoselective epoxidation of the double bond at C-4 of sphingosines to provide phytosphingosine relatives such as alpha-galactosylceramide KRN7000. Tetrahedron 1998. 54: 3141-3150.
37. Chung, Y., Chang, S. Y. and Kang, C. Y., Kinetic analysis of oral tolerance: memory lymphocytes are refractory to oral tolerance. J. Immunol. 1999. 163: 3692-3698.