Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase: Evidence for a TS intermediate and TS half-sites reactivity

Journal of Biological Chemistry

Volumn 277, Issue 45, 2002, Pages 43126-43136

  Johnson, Eric F ^a   Hinz, Wolfgang ^b   Atreya, Chloé E ^b   Maley, Frank ^a   Anderson, Karen S ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK STATE DEPARTMENT OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; ESCHERICHIA COLI;

KINETIC METHODS;

ENZYMES;

DIHYDROFOLATE REDUCTASE; THYMIDYLATE SYNTHASE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TOXOPLASMA GONDII;

ANIMALS; GENETIC VECTORS; KINETICS; MODELS, MOLECULAR; MODELS, THEORETICAL; MULTIENZYME COMPLEXES; PLASMIDS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TOXOPLASMA;

ESCHERICHIA COLI; LEISHMANIA MAJOR; TOXOPLASMA GONDII;

EID: 0037044746     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206523200     Document Type: Article

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