The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cδ and JNK activation

Journal of Biological Chemistry

Volumn 282, Issue 20, 2007, Pages 15271-15283

  Lee, Sung A ^a   Jung, Mira ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CARCINOMA; NUCLEOSIDES; PROTEIN KINASE; SANGIVAMYCIN;

ACTIVATION ANALYSIS; ENZYME KINETICS; FLUORESCENCE; PHOSPHORYLATION; PROTEINS; TUMORS;

CELL DEATH;

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 6; CASPASE 7; CASPASE 9; DOXORUBICIN; LAMIN A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN KINASE C DELTA; ROTTLERIN; SANGIVAMYCIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; CASPASE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PARP1 PROTEIN, HUMAN; PYRIMIDINE NUCLEOSIDE; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CELL ACTIVATION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG POTENCY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; BREAST TUMOR; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; ENZYME ACTIVATION; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; METABOLISM; MULTIDRUG RESISTANCE; PROTEIN PROCESSING; TUMOR CELL LINE;

ANTHRACENES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LAMIN TYPE A; MAP KINASE KINASE 4; NEOPLASM PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE C-DELTA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIMIDINE NUCLEOSIDES;

EID: 34447524115     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701362200     Document Type: Article

References (79)

1. Bergstrom, D. E., Brattesani, A. J., Ogawa, M. K., Reddy, P. A., Schweickert, M. J., Balzarini, J., and De Clercq, E. (1984) J. Med. Chem. 27, 285-292
2. Turk, S. R., Shipman, C., Jr., Nassiri, R., Genzlinger, G., Krawczyk, S. H., Townsend, L. B., and Drach, J. C. (1987) Antimicrob. Agents Chemother. 31, 544-550
3. Ritch, P. S., Glazer, R. I., Cunningham, R. E., and Shackney, S. E. (1981) Cancer Res. 41, 1784-1788
4. Glazer, R. I., Hartman, K. D., and Cohen, O. J. (1981) Biochem. Pharmacol. 30, 2697-2701
5. Cohen, M. B., and Glazer, R. I. (1985) Mol. Pharmacol. 27, 349-355
6. Cavins, J. A., Hall, T. C., Olson, K. B., Khung, C. L., Horton, J., Colsky, J., and Shadduck, R. K. (1967) Cancer Chemother. Rep. 51, 197-200
7. Hardesty, C. T., Chaney, N. A., Waravdekar, V. S., and Mead, J. A. (1974) Cancer Res. 34, 1005-1009
8. Robins, R. K., and Revankar, G. R. (1985) Med. Res. Rev. 5, 273-296
9. Migawa, M. T., Drach, J. C., and Townsend, L. B. (2005) J. Med. Chem. 48, 3840-3851
10. Ding, Y., An, H., Hong, Z., and Girardet, J. L. (2005) Bioorg. Med. Chem. Lett. 15, 725-727
11. Ravelo, A. G., Estevez-Braun, A., Chavez-Orellana, H., Perez-Sacau, E., and Mesa-Siverio, D. (2004) Curr. Top. Med. Chem. 4, 241-265
12. Biron, K. K., Harvey, R. J., Chamberlain, S. C., Good, S. S., Smith, A. A., III, Davis, M. G., Talarico, C. L., Miller, W. H., Ferris, R., Dornsife, R. E., Stanat, S. C., Drach, J. C., Townsend, L. B., and Koszalka, G. W. (2002) Antimicrob. Agents Chemother. 46, 2365-2372
13. Koszalka, G. W., Good, S. S., Boyd, L., Drach, J. C., Townsend, L. B., and Biron, K. K. (2002) Antimicrob. Agents Chemother. 46, 2373-2380
14. Loomis, C. R., and Bell, R. (1988) J. Biol. Chem. 263, 1682-1692
15. Osada, H., Sonoda, T., Tsunoda, K., and Isono, K. (1989) J. Antibiot. (Tokyo) 42, 102-106
16. Palczewski, K., Kahn, N., and Hargrave, P. A. (1990) Biochemistry 29, 6276-6282
17. Saffer, J. D., and Glazer, R. L. (1981) Mol. Pharmacol. 20, 211-217
18. Osada, H., Cui, C.-B., Onose, R., and Hanaoka, F. (1997) Bioorg. Med. Chem. 5, 193-203
19. Kim, M. K., Cho, Y.-H., Kim, J. M., Chun, M. W., Lee, S. K., Lim, Y., and Lee, C.-H. (2005) Cancer Lett. 223, 239-247
20. Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., and Ichijo, H. (2001) EMBO Rep. 2, 222-228
21. Hengartner, M. O. (2000) Nature 407, 770-776
22. Thompson, C. B. (1995) Science 267, 1456-1462
23. Los, M., Wesselborg, S., and Schuize-Osthoff, K. (1999) Free Immunity 10, 629-639
24. Yuan, J., and Yankner, B. A. (2000) Nature 407, 802-809
25. Rao, L., and White, E. (1997) Curr. Opin. Genet. Dev. 7, 52-58
26. Kroemer, G. (1997) Nat. Med. 3, 614-620
27. Nuñez, G., Benedict, M. A., Hu, Y., and Inohara, N. (1998) Oncogene 17, 3237-3245
28. Gross, A., McDonnell, J. M., and Korsmeyer, S. J. (1999) Genes Dev. 13, 1899-1911
29. Oltvai, Z. N., Milliman, C. L., and Korsmeyer, S. J. (1993) Cell 74, 609-619
30. Wei, M. C., Zong, W. X., Cheng, E. H., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., and Korsmeyer, S. J. (2001) Science 292, 727-730
31. Leszczynski, D. (1995) Oncol. Res. 7, 471-480
32. Lucas, M., and Sanchez-Margalet, V. (1995) Gen. Pharmacol. 26, 881-887
33. Reyland, M. E., Anderson, S. M., Matassa, A. A., Barzen, K. A., and Quissell, D. O. (1999) J. Biol. Chem. 274, 19115-19123
34. DalPra, I., Whitfield, J. F., Chiarini, A., and Armato, U. (2000) Exp. Cell Res. 255, 171-183
35. Goubout, J. P., Pesavento, J., Hartman, M. E., Manson, S. R., and Freund, G. G. (2002) J. Biol. Chem. 277, 2554-2561
36. Emoto, Y., Kisaki, H., Manome, Y., Kharbanda, S., and Kufe, D. (1996) Blood 87, 1991-1996
37. Mizuno, K., Noda, K., Araki, T., Imaoka, T., Kobayashi, Y., Akita, Y., Shimonaka, M., Kishi, S., and Ohno, S. (1997) Eur. J. Biochem. 250, 7-18
38. Frasch, S. C., Henson, P. M., Kailey, J. M., Richter, D. A., Janes, M. S., Fadok, V. A., and Bratton, D. L. (2000) J. Biol. Chem. 275, 23065-23073
39. Kharbanda, S., Pandey, P., Ren, R., Mayer, B., Zon, L., and Kufe, D. (1995) J. Biol. Chem. 270, 30278-30281
40. Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E., Zon, L. I., Kyriakis, J. M., Haimovitz-Friedman, A., Fuks, Z., and Kolesnick, R. N. (1996) Nature 380, 75-79
41. Testolin, L., Carson, C., Wang, Y., Walker, P. R., Armato, U., and Sikorska, M. (1997) Exp. Cell Res. 230, 220-232
42. Derijard, B., Hibi, M., Wu, I. H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. J. (1994) Cell 76, 1025-1037
43. Gupta, S., Campbell, D., Derijard, B., and Davis, R. J. (1995) Science 267, 389-393
44. Yamamoto, K., Ichijo, H., and Korsmeyer, S. J. (1999) Mol. Cell. Biol. 19, 8469-8478
45. Lei, K., and Davis, R. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2432-2437
46. Lee, S. A., Karaszkiewicz, J. W., and Anderson, W. B. (1992) Cancer Res. 52, 3750-3759
47. Lee, S. A., Dritschilo, A., and Jung, M. (2001) J. Biol. Chem. 276, 11783-11790
48. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
49. Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., and Vogelstein, B. (1998) Science 282, 1497-1501
50. Amellem, O., Stokke, T., Sandvik, J. A., Smedshammer, L., and Pettersen, E. O. (1990) Exp. Cell Res. 232, 361-370
51. Ogretmen, B., and Safa, A. R. (1997) Oncogene 14, 499-506
52. Cai, Z., Capoulade, C., Moyret-Lalle, C., Amor-Gueret, M., Feunteun, J., Larsen, A. K., Paillerets, B. B., and Chouaib, S. (1997) Oncogene 15, 2817-2826
53. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., and Dixit, V. M. (1996) J. Biol. Chem. 271, 16443-16446
54. Duan, H., Chinnaiyan, A. M., Hudson, P. L., Wing, J. P., He, W. W., and Dixit, V. M. (1996) J. Biol. Chem. 271, 1621-1625
55. Cohen, G. M. (1997) Biochem. J. 326, 1-16
56. Goldberg, M., Harel, A., and Gruenbaum, Y. (1999) Crit. Rev. Eukaryot. Gene Expression 9, 285-293
57. Oberhammer, F. A., Hochegger, K., Froschl, G., Tiefenbacher, R., and Pavelka, M. (1994) J. Cell Biol. 126, 827-837
58. Rao, L., Perez, D., and White, E. (1996) J. Cell Biol. 135, 1441-1455
59. Virag, L., and Szabo, C. (2002) Pharmacol. Rev. 54, 375-429
60. Oliver, F. J., de la Rubia, G., Rolli, V., Ruiz-Ruiz, M. C., de Murcia, G., and Murcia, J. M. (1998) J. Biol. Chem. 273, 33533-33539
61. Bossy-Wetzel, E., Bakiri, L., and Yaniv, M. (1997) EMBO J. 16, 1695-1709
62. Smeal, T., Hibi, M., and Karin, M. (1994) EMBO J. 13, 6006-6010
63. Binetruy, B., Smeal, T., and Karin, M. (1991) Nature 351, 122-127
64. Devary, Y., Gottlieb, R. A., Smeal, T., and Karin, M. (1992) Cell 71, 1081-1091
65. Radler-Pohl, A., Sachsenmaier, C., Gebel, S., Auer, H. P., Bruder, J. T., Rapp, U., Angel, P., Rahmsdorf, H. J., and Herrlich, P. (1993) EMBO J. 12, 1005-1012
66. Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., and Karin, M. (1991) Nature 354, 494-496
67. Lei, K., Nimnual, A., Zong, W. X., Kennedy, N. J., flavell, R. A., Thompson, C. B., Bar-Sagi, D., and Davis, R. J. (2002) Mol. Cell. Biol. 22, 4929-4942
68. Palmada, M., Kanwal, S., Rutkoshi, N. J., Gustafson-Brown, C., Johnson, R. S., Wisdom, R., and Carter, B. D. (2002) J. Cell Biol. 158, 453-461
69. Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., and Davis, R. J. (2000) Science 288, 870-874
70. Willis, S., Day, C. L., Hinds, M. G., and Huang, D. C. S. (2003) J. Cell Sci. 116, 4053-4056
71. Yang, D. D., Kuan, C. Y., Whitmarsh, A. J., rincon, M., Zheng, T. S., Davis, R. J., Rakic, P., and Flavell, R. A. (1997) Nature 389, 865-870
72. Basu, A., and Haldar, S. (2003) FEBS Lett. 538, 41-47
73. Fan, M., Goodwin, M., Vu, T., Brantley-Finley, C., Gaarde, W. A., and Chambers, T. C. (2000) J. Biol. Chem. 275, 29980-29985
74. Drew, L., Fine, R. L., Do, T. N., Douglas, G. P., and Petrylak, D. P. (2002) Clin. Cancer Res. 8, 3922-3932
75. Schroeter, H., Boyd, C. S., Ahmed, R., Spencer, J. P. E., Duncan, R. F., Rice-Evans, C., and Cadenas, E. (2003) Biochem. J. 372, 359-369
76. Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y., Campbell, A., Sudha, T., Yuan, Z., Narula, J., Weichselbaum, R., Nalin, C., and Kufe, D. (2000) J. Biol. Chem. 275, 322-327
77. Okorokov, A. L., and Milner, J. (1997) Oncol. Res. 9, 267-273
78. Gelis, C., Mavon, A., and Vicendo, P. (2005) Photochem. Photobiol. 81, 975-982
79. Molinari, M., Okorokov, A. L., and Milner, J. (1996) Oncogene 13, 2077-2086