Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(β-d-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy- β-d-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine

Journal of Medicinal Chemistry

Volumn 48, Issue 11, 2005, Pages 3840-3851

  Migawa, Michael T ^a,b   Drach, John C ^a   Townsend, Leroy B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AZASANGIVAMYCIN; 3 AMINO 5 METHYL 1 (2 DEOXY BETA DEXTRO RIBOFURANOSYL) 1,5 DIHYDRO 1,4,5,6,7,8 HEXAAZAACENAPHTHYLENE; 3 AMINO 5 METHYL 1 (BETA DEXTRO RIBOFURANOSYL) 1,5 DIHYDRO 1,4,5,6,7,8 HEXAAZAACENAPHTHYLENE; 4 AMINO 1 (BETA DEXTRO RIBODURANOSYL)PYRROLO[2,3 D] 1,2,3 TRIAZINE 5 CARBOXAMIDOXIME; 4 AMINO 1 (BETA DEXTRO RIBOFURANOSYL)PYRROLO[2,3 D] 1,2,3 TRIAZINE 5 CARBOXAMIDRAZONE; ACICLOVIR; AMIDE; AMINE; AMMONIA; ANTIBIOTIC AGENT; CHLORINE DERIVATIVE; CYANIDE; FURAN DERIVATIVE; GANCICLOVIR; HETEROCYCLIC COMPOUND; HYDRAZINE DERIVATIVE; HYDROGEN SULFIDE; HYDROXYLAMINE; METHANOL; NAPHTHALENE DERIVATIVE; NITRO DERIVATIVE; NITROUS ACID; NUCLEOSIDE ANALOG; PALLADIUM; PYRROLE DERIVATIVE; SANGIVAMYCIN; SANGIVAMYCIN DERIVATIVE; TOYOCAMYCIN DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; TRICIRIBINE; UNCLASSIFIED DRUG; WATER;

ADDITION REACTION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DIELS ALDER REACTION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; REACTION ANALYSIS;

ACENAPHTHENES; ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; DRUG DESIGN; HERPESVIRUS 1, HUMAN; HIV-1; HUMANS; MICE; MOLECULAR CONFORMATION; PYRROLES; RIBONUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 20144376146     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0402014     Document Type: Article

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