-
1
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
Mora A., Komander D., van Aalten D.M., and Alessi D.R. PDK1, the master regulator of AGC kinase signal transduction. Semin. Cell Develop. Biol. 15 (2004) 161-170
-
(2004)
Semin. Cell Develop. Biol.
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
van Aalten, D.M.3
Alessi, D.R.4
-
2
-
-
0037099658
-
Essential role of PDK1 in regulating cell size and development in mice
-
Lawlor M.A., Mora A., Ashby P.R., Williams M.R., Murray-Tait V., Malone L., Prescott A.R., Lucocq J.M., and Alessi D.R. Essential role of PDK1 in regulating cell size and development in mice. Embo J. 21 (2002) 3728-3738
-
(2002)
Embo J.
, vol.21
, pp. 3728-3738
-
-
Lawlor, M.A.1
Mora, A.2
Ashby, P.R.3
Williams, M.R.4
Murray-Tait, V.5
Malone, L.6
Prescott, A.R.7
Lucocq, J.M.8
Alessi, D.R.9
-
3
-
-
0141737071
-
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
-
Mora A., Davies A.M., Bertrand L., Sharif I., Budas G.R., Jovanovic S., Mouton V., Kahn C.R., Lucocq J.M., Gray G.A., Jovanovic A., and Alessi D.R. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. Embo J. 22 (2003) 4666-4676
-
(2003)
Embo J.
, vol.22
, pp. 4666-4676
-
-
Mora, A.1
Davies, A.M.2
Bertrand, L.3
Sharif, I.4
Budas, G.R.5
Jovanovic, S.6
Mouton, V.7
Kahn, C.R.8
Lucocq, J.M.9
Gray, G.A.10
Jovanovic, A.11
Alessi, D.R.12
-
4
-
-
2442681621
-
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development
-
Hinton H.J., Alessi D.R., and Cantrell D.A. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development. Nat. Immunol. 5 (2004) 539-545
-
(2004)
Nat. Immunol.
, vol.5
, pp. 539-545
-
-
Hinton, H.J.1
Alessi, D.R.2
Cantrell, D.A.3
-
5
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
Williams M.R., Arthur J.S., Balendran A., van der Kaay J., Poli V., Cohen P., and Alessi D.R. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10 (2000) 439-448
-
(2000)
Curr. Biol.
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.2
Balendran, A.3
van der Kaay, J.4
Poli, V.5
Cohen, P.6
Alessi, D.R.7
-
6
-
-
0034634443
-
Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms
-
Balendran A., Hare G.R., Kieloch A., Williams M.R., and Alessi D.R. Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms. FEBS Lett. 484 (2000) 217-223
-
(2000)
FEBS Lett.
, vol.484
, pp. 217-223
-
-
Balendran, A.1
Hare, G.R.2
Kieloch, A.3
Williams, M.R.4
Alessi, D.R.5
-
7
-
-
0032585532
-
Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
-
Dutil E.M., Toker A., and Newton A.C. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr. Biol. 8 (1998) 1366-1375
-
(1998)
Curr. Biol.
, vol.8
, pp. 1366-1375
-
-
Dutil, E.M.1
Toker, A.2
Newton, A.C.3
-
8
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
LeGood J.A., Ziegler W.H., Parekh D.B., Alessi D.R., Cohen P., and Parker P.J. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281 (1998) 2042-2045
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
LeGood, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
Parker, P.J.6
-
9
-
-
0033525860
-
Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII
-
Edwards A.S., Faux M.C., Scott J.D., and Newton A.C. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. J. Biol. Chem. 274 (1999) 6461-6468
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6461-6468
-
-
Edwards, A.S.1
Faux, M.C.2
Scott, J.D.3
Newton, A.C.4
-
10
-
-
0035380478
-
The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1
-
Gao T., Toker A., and Newton A.C. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. J. Biol. Chem. 276 (2001) 19588-19596
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19588-19596
-
-
Gao, T.1
Toker, A.2
Newton, A.C.3
-
11
-
-
0035976977
-
The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase
-
Sonnenburg E.D., Gao T., and Newton A.C. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. J. Biol. Chem. 276 (2001) 45289-45297
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45289-45297
-
-
Sonnenburg, E.D.1
Gao, T.2
Newton, A.C.3
-
12
-
-
27944482145
-
In vivo role of the phosphate groove of PDK1 defined by knock in mutation
-
Collins B.J., Deak M., Murray-Tait V., Storey K.G., and Alessi D.R. In vivo role of the phosphate groove of PDK1 defined by knock in mutation. J. Cell Sci. 118 (2005) 5023-5034
-
(2005)
J. Cell Sci.
, vol.118
, pp. 5023-5034
-
-
Collins, B.J.1
Deak, M.2
Murray-Tait, V.3
Storey, K.G.4
Alessi, D.R.5
-
13
-
-
2942563750
-
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
-
McManus E.J., Collins B.J., Ashby P.R., Prescott A.R., Murray-Tait V., Armit L.J., Arthur J.S., and Alessi D.R. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. Embo J. 23 (2004) 2071-2082
-
(2004)
Embo J.
, vol.23
, pp. 2071-2082
-
-
McManus, E.J.1
Collins, B.J.2
Ashby, P.R.3
Prescott, A.R.4
Murray-Tait, V.5
Armit, L.J.6
Arthur, J.S.7
Alessi, D.R.8
-
14
-
-
0030894024
-
Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form
-
Stempka L., Girod A., Muller H.J., Rincke G., Marks F., Gschwendt M., and Bossemeyer D. Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form. J. Biol. Chem. 272 (1997) 6805-6811
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6805-6811
-
-
Stempka, L.1
Girod, A.2
Muller, H.J.3
Rincke, G.4
Marks, F.5
Gschwendt, M.6
Bossemeyer, D.7
-
15
-
-
0344141205
-
Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643
-
Stempka L., Schnolzer M., Radke S., Rincke G., Marks F., and Gschwendt M. Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. J. Biol. Chem. 274 (1999) 8886-8892
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8886-8892
-
-
Stempka, L.1
Schnolzer, M.2
Radke, S.3
Rincke, G.4
Marks, F.5
Gschwendt, M.6
-
17
-
-
33744926666
-
PKD at the crossroads of DAG and PKC signaling
-
Wang Q.J. PKD at the crossroads of DAG and PKC signaling. Trends Pharmacol. Sci. 27 (2006) 317-323
-
(2006)
Trends Pharmacol. Sci.
, vol.27
, pp. 317-323
-
-
Wang, Q.J.1
-
19
-
-
0034686420
-
Protein kinase D.A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes
-
Matthews S.A., Rozengurt E., and Cantrell D. Protein kinase D.A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes. J. Exp. Med. 191 (2000) 2075-2082
-
(2000)
J. Exp. Med.
, vol.191
, pp. 2075-2082
-
-
Matthews, S.A.1
Rozengurt, E.2
Cantrell, D.3
-
20
-
-
33847038352
-
Association of protein kinase C-delta with the B cell antigen receptor complex
-
Pracht C., Minguet S., Leitges M., Reth M., and Huber M. Association of protein kinase C-delta with the B cell antigen receptor complex. Cell Signal. 19 (2007) 715-722
-
(2007)
Cell Signal.
, vol.19
, pp. 715-722
-
-
Pracht, C.1
Minguet, S.2
Leitges, M.3
Reth, M.4
Huber, M.5
-
21
-
-
0037160046
-
Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon)
-
Brandlin I., Eiseler T., Salowsky R., and Johannes F.J. Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon). J. Biol. Chem. 277 (2002) 45451-45457
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45451-45457
-
-
Brandlin, I.1
Eiseler, T.2
Salowsky, R.3
Johannes, F.J.4
-
22
-
-
0033543570
-
Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu
-
Matthews S.A., Rozengurt E., and Cantrell D. Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu. J. Biol. Chem. 274 (1999) 26543-26549
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26543-26549
-
-
Matthews, S.A.1
Rozengurt, E.2
Cantrell, D.3
-
23
-
-
4544248747
-
G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon
-
Rey O., Reeve Jr. J.R., Zhukova E., Sinnett-Smith J., and Rozengurt E. G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon. J. Biol. Chem. 279 (2004) 34361-34372
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34361-34372
-
-
Rey, O.1
Reeve Jr., J.R.2
Zhukova, E.3
Sinnett-Smith, J.4
Rozengurt, E.5
-
24
-
-
1642379541
-
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling
-
Storz P., Doppler H., and Toker A. Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol. Cell Biol. 24 (2004) 2614-2626
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 2614-2626
-
-
Storz, P.1
Doppler, H.2
Toker, A.3
-
25
-
-
33750058260
-
Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development
-
Hinton H.J., Clarke R.G., and Cantrell D.A. Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development. FEBS Lett. 580 (2006) 5845-5850
-
(2006)
FEBS Lett.
, vol.580
, pp. 5845-5850
-
-
Hinton, H.J.1
Clarke, R.G.2
Cantrell, D.A.3
-
26
-
-
22244490365
-
Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism
-
Czerwinski R., Aulabaugh A., Greco R.M., Olland S., Malakian K., Wolfrom S., Lin L., Kriz R., Stahl M., Huang Y., Liu L., and Chaudhary D. Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism. Biochemistry 44 (2005) 9563-9573
-
(2005)
Biochemistry
, vol.44
, pp. 9563-9573
-
-
Czerwinski, R.1
Aulabaugh, A.2
Greco, R.M.3
Olland, S.4
Malakian, K.5
Wolfrom, S.6
Lin, L.7
Kriz, R.8
Stahl, M.9
Huang, Y.10
Liu, L.11
Chaudhary, D.12
|