Identification of two prion protein regions that modify scrapie incubation time

Journal of Virology

Volumn 75, Issue 3, 2001, Pages 1408-1413

  Supattapone, S ^a   Muramoto, T ^a   Legname, G ^a   Mehlhorn, I ^a   Cohen, F E ^a   DeArmond, S J ^a   Prusiner, S B ^a   Scott, M R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOBLOTTING; INCUBATION TIME; MOUSE; NONHUMAN; PRION; PRIORITY JOURNAL; SCRAPIE;

ANIMALS; EPITOPES; MICE; MICE, TRANSGENIC; PRIONS; SCRAPIE; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 0035152345     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.3.1408-1413.2001     Document Type: Article

References (35)

1. Properties and characteristics of scrapie PrP 27-30 protein
2. Linkage of prion protein and scrapie incubation time genes
3. Encephalopathy in mice produced by inoculation with scrapie brain material
4. Structure of the recombinant full-length hamster prion protein PrP(29-231): The N terminus is highly flexible
5. Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie
6. Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice
7. Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
8. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins
9. Solution structure of Syrian hamster prion protein rPrP(90-231)
10. Mice with gene targeted prion protein alterations show that Prn-p, Sinc and Prni are congruent
11. Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α-helix
12. The sequential development of abnormal prion protein accumulation in mice with Creutzfeldt-Jakob disease
13. Recombinant scrapie-like prion protein of 106 amino acids is soluble
14. A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform
15. Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells
16. A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells
17. Novel proteinaceous infectious particles cause scrapie
18. Prions
19. Further purification and characterization of scrapie prions
20. Measurement of the scrapie agent using an incubation time interval assay
21. Prion protein biology
22. To what extent is strain variation evidence for an independent genome in the agent of the transmissible spongiform encephalopathies?
23. NMR structure of the mouse prion protein domain PrP(121-231)
24. NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231)
25. Sc molecules with different conformations
26. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
27. Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes
28. Chimeric prion protein expression in cultured cells and transgenic mice
29. Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins
30. Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice
31. Elimination of prions by branched polyamines and implications for therapeutics
32. Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice
33. Distinct prion proteins in short and long scrapie incubation period mice
34. Mapping the prion protein using recombinant antibodies
35. Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein