-
1
-
-
0042844744
-
Natural products as sources of new drugs over the period 1981-2002
-
Newman DJ, Cragg GM, Snader KM: Natural products as sources of new drugs over the period 1981-2002. J Nat Prod (2003) 66(7):1022-1037.
-
(2003)
J Nat Prod
, vol.66
, Issue.7
, pp. 1022-1037
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
2
-
-
29444454770
-
Natural products as drug leads: An old process or the new hope for drug discovery?
-
Kingston DG, Newman DJ: Natural products as drug leads: An old process or the new hope for drug discovery? IDrugs (2005) 8(12):990-992.
-
(2005)
IDrugs
, vol.8
, Issue.12
, pp. 990-992
-
-
Kingston, D.G.1
Newman, D.J.2
-
3
-
-
33644973407
-
Marine natural products
-
Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR: Marine natural products. Nat Prod Rep (2006) 23(1):26-78.
-
(2006)
Nat Prod Rep
, vol.23
, Issue.1
, pp. 26-78
-
-
Blunt, J.W.1
Copp, B.R.2
Munro, M.H.3
Northcote, P.T.4
Prinsep, M.R.5
-
4
-
-
4344650390
-
Marine natural products and related compounds in clinical and advanced preclinical trials
-
Newman DJ, Cragg GM: Marine natural products and related compounds in clinical and advanced preclinical trials. J Nat Prod (2004) 67(8):1216-1238.
-
(2004)
J Nat Prod
, vol.67
, Issue.8
, pp. 1216-1238
-
-
Newman, D.J.1
Cragg, G.M.2
-
5
-
-
3042617137
-
-
Newman DJ, Cragg GM: Advanced preclinical and clinical trials of natural products and related compounds from marine sources. Curr Med Chem (2004) 11(13):1693-1713. •• A comprehensive review covering the development of marine drugs.
-
Newman DJ, Cragg GM: Advanced preclinical and clinical trials of natural products and related compounds from marine sources. Curr Med Chem (2004) 11(13):1693-1713. •• A comprehensive review covering the development of marine drugs.
-
-
-
-
6
-
-
27744495564
-
-
Alonso D, Castro A, Martinez A: Marine compounds for the therapeutic treatment of neurological disorders. Expert Opin Ther Pat (2005) 15(10):1377-1386. • The first specific review, focused mainly on patents, to describe marine compounds as potential therapies in neurology.
-
Alonso D, Castro A, Martinez A: Marine compounds for the therapeutic treatment of neurological disorders. Expert Opin Ther Pat (2005) 15(10):1377-1386. • The first specific review, focused mainly on patents, to describe marine compounds as potential therapies in neurology.
-
-
-
-
7
-
-
0347989461
-
Conus venoms: A rich source of novel ion channel-targeted peptides
-
Terlau H, Olivera BM: Conus venoms: A rich source of novel ion channel-targeted peptides. Physiol Rev (2004) 84(1):41-68.
-
(2004)
Physiol Rev
, vol.84
, Issue.1
, pp. 41-68
-
-
Terlau, H.1
Olivera, B.M.2
-
8
-
-
3042631514
-
Drugs from the sea: Conopeptides as potential therapeutics
-
Livett BG, Gayler KR, Khalil Z: Drugs from the sea: Conopeptides as potential therapeutics. Curr Med Chem (2004) 11(13):1715-1723.
-
(2004)
Curr Med Chem
, vol.11
, Issue.13
, pp. 1715-1723
-
-
Livett, B.G.1
Gayler, K.R.2
Khalil, Z.3
-
9
-
-
23444445034
-
Novel pain relief via marine snails
-
Sharp D: Novel pain relief via marine snails. Lancet (2005) 366(9484):439-440.
-
(2005)
Lancet
, vol.366
, Issue.9484
, pp. 439-440
-
-
Sharp, D.1
-
10
-
-
33748646783
-
N-type calcium channel blockers: Novel therapeutics for the treatment of pain
-
Schroeder CI, Doering CJ, Zamponi GW, Lewis RJ: N-type calcium channel blockers: Novel therapeutics for the treatment of pain. Med Chem (2006) 2(5):535-543.
-
(2006)
Med Chem
, vol.2
, Issue.5
, pp. 535-543
-
-
Schroeder, C.I.1
Doering, C.J.2
Zamponi, G.W.3
Lewis, R.J.4
-
11
-
-
34347349543
-
Products and pipeline
-
Elan Corp plc:, April 21
-
Elan Corp plc: Products and pipeline. Company Communication (2005): April 21.
-
(2005)
Company Communication
-
-
-
12
-
-
34347366721
-
AM-336 and neurological drug candidates
-
AMRAD Corp Ltd: Drug development pipeline:, :February 07
-
AMRAD Corp Ltd: Drug development pipeline: AM-336 and neurological drug candidates. Company Communication (2005):February 07.
-
(2005)
Company Communication
-
-
-
13
-
-
33747188678
-
Toxin insights into nicotinic acetylcholine receptors
-
Dutertre S, Lewis RJ: Toxin insights into nicotinic acetylcholine receptors. Biochem Pharmacol (2006) 72(6):661-670.
-
(2006)
Biochem Pharmacol
, vol.72
, Issue.6
, pp. 661-670
-
-
Dutertre, S.1
Lewis, R.J.2
-
14
-
-
0038661000
-
A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo
-
Sandall DW, Satkunanathan N, Keays DA, Polidano MA, Liping X, Pham V, Down JG, Khalil Z, Livett BG, Gayler KR: A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry (2003) 42(22):6904-6911.
-
(2003)
Biochemistry
, vol.42
, Issue.22
, pp. 6904-6911
-
-
Sandall, D.W.1
Satkunanathan, N.2
Keays, D.A.3
Polidano, M.A.4
Liping, X.5
Pham, V.6
Down, J.G.7
Khalil, Z.8
Livett, B.G.9
Gayler, K.R.10
-
15
-
-
33750957742
-
Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor
-
Livett BG, Sandall DW, Keays D, Down J, Gayler KR, Satkunanathan N, Khalil Z: Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor. Toxicon (2006) 48(7):810- 829.
-
(2006)
Toxicon
, vol.48
, Issue.7
, pp. 810-829
-
-
Livett, B.G.1
Sandall, D.W.2
Keays, D.3
Down, J.4
Gayler, K.R.5
Satkunanathan, N.6
Khalil, Z.7
-
16
-
-
15444362099
-
Conus peptides - a rich pharmaceutical treasure
-
Wang CZ, Chi CW: Conus peptides - a rich pharmaceutical treasure. Acta Biochim Biophys Sin (Shanghai) (2004) 36(11):713-723.
-
(2004)
Acta Biochim Biophys Sin (Shanghai)
, vol.36
, Issue.11
, pp. 713-723
-
-
Wang, C.Z.1
Chi, C.W.2
-
17
-
-
34347362451
-
-
Xenome Limited: Xen2174 is effective in the treatment of neuropathic pain. Press Release (2003): July 15.
-
Xenome Limited: Xen2174 is effective in the treatment of neuropathic pain. Press Release (2003): July 15.
-
-
-
-
18
-
-
9144236304
-
Conantokins: Peptide antagonists of NMDA receptors
-
Layer RT, Wagstaff JD, White HS: Conantokins: Peptide antagonists of NMDA receptors. Curr Med Chem (2004) 11(23):3073-3084.
-
(2004)
Curr Med Chem
, vol.11
, Issue.23
, pp. 3073-3084
-
-
Layer, R.T.1
Wagstaff, J.D.2
White, H.S.3
-
19
-
-
0034332336
-
Conantokins: Inhibitors of ion flow through the N-methyl-D-aspartate receptor channels
-
Castellino FJ, Prorok M: Conantokins: Inhibitors of ion flow through the N-methyl-D-aspartate receptor channels. Curr Drug Targets (2000) 1(3):219-235.
-
(2000)
Curr Drug Targets
, vol.1
, Issue.3
, pp. 219-235
-
-
Castellino, F.J.1
Prorok, M.2
-
20
-
-
0033553511
-
Contulakin-G, an O-glycosylated invertebrate neurotensin
-
Craig AG, Norberg T, Griffin D, Hoeger C, Akhtar M, Schmidt K, Low W, Dykert J, Richelson E, Navarro V, Mazella J et al: Contulakin-G, an O-glycosylated invertebrate neurotensin. J Biol Chem (1999) 274(20):13752-13759.
-
(1999)
J Biol Chem
, vol.274
, Issue.20
, pp. 13752-13759
-
-
Craig, A.G.1
Norberg, T.2
Griffin, D.3
Hoeger, C.4
Akhtar, M.5
Schmidt, K.6
Low, W.7
Dykert, J.8
Richelson, E.9
Navarro, V.10
Mazella, J.11
-
21
-
-
2342649960
-
The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs
-
Barton ME, White HS, Wilcox KS: The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs. Epilepsy Res (2004) 59(1):13-24.
-
(2004)
Epilepsy Res
, vol.59
, Issue.1
, pp. 13-24
-
-
Barton, M.E.1
White, H.S.2
Wilcox, K.S.3
-
22
-
-
33749645832
-
Ziconotide - a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain - a short review
-
Klotz U: Ziconotide - a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain - a short review. Int J Clin Pharmacol Ther (2006) 44(10):478-483.
-
(2006)
Int J Clin Pharmacol Ther
, vol.44
, Issue.10
, pp. 478-483
-
-
Klotz, U.1
-
23
-
-
33750611879
-
Ziconotide: A new nonopioid intrathecal analgesic for the treatment of chronic pain
-
Wallace MS: Ziconotide: A new nonopioid intrathecal analgesic for the treatment of chronic pain. Expert Rev Neurother (2006) 6(10):1423-1428.
-
(2006)
Expert Rev Neurother
, vol.6
, Issue.10
, pp. 1423-1428
-
-
Wallace, M.S.1
-
24
-
-
0028836065
-
Effect of continuous intrathecal infusion of ω-conopetides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate test in rats
-
Malmberg AB, Yaksh TL: Effect of continuous intrathecal infusion of ω-conopetides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate test in rats. Pain (1995) 60(1):83-90.
-
(1995)
Pain
, vol.60
, Issue.1
, pp. 83-90
-
-
Malmberg, A.B.1
Yaksh, T.L.2
-
25
-
-
34347335043
-
Ion channels in drug discovery & development - SRI's Fourth Annual Conference, Philadelphia, PA, USA
-
October 04-05
-
Kelety B: Ion channels in drug discovery & development - SRI's Fourth Annual Conference, Philadelphia, PA, USA. IDDB Meeting Report (2004): October 04-05.
-
(2004)
IDDB Meeting Report
-
-
Kelety, B.1
-
26
-
-
9144230737
-
Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: A randomized controlled trial
-
Staats PS, Yearwood T, Charapata SG, Presley RW, Wallace MS, Byas-Smith M, Fisher R, Bryce DA, Mangieri EA, Luther RR, Mayo M et al: Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: A randomized controlled trial. J Am Med Assoc, (2004) 291(1):63-70.
-
(2004)
J Am Med Assoc
, vol.291
, Issue.1
, pp. 63-70
-
-
Staats, P.S.1
Yearwood, T.2
Charapata, S.G.3
Presley, R.W.4
Wallace, M.S.5
Byas-Smith, M.6
Fisher, R.7
Bryce, D.A.8
Mangieri, E.A.9
Luther, R.R.10
Mayo, M.11
-
27
-
-
34347362082
-
Neuroprotection by selective blockade of N-type neuronal calcium channels: Evidence for a wide therapeutic window in focal cerebral ischemia
-
Amsterdam, the Netherlands , Abs 73
-
Zhao Q, Khansari P, Luther RR: Neuroprotection by selective blockade of N-type neuronal calcium channels: Evidence for a wide therapeutic window in focal cerebral ischemia. International Symposium on Pharmacology of Cerebral Ischemia, Amsterdam, the Netherlands (1998) 7: Abs 73.
-
(1998)
International Symposium on Pharmacology of Cerebral Ischemia
, vol.7
-
-
Zhao, Q.1
Khansari, P.2
Luther, R.R.3
-
28
-
-
0028171089
-
2+- channel blocker prevents CA1 injury 24h following severe forebrain ischemia and reduces infarction following focal ischemia
-
2+- channel blocker prevents CA1 injury 24h following severe forebrain ischemia and reduces infarction following focal ischemia. J Cereb Blood Flow Metab (1994) 14(6):903-910.
-
(1994)
J Cereb Blood Flow Metab
, vol.14
, Issue.6
, pp. 903-910
-
-
Buchan, A.M.1
Gertler, S.Z.2
Li, H.3
-
29
-
-
34347365083
-
-
Elan Corp plc: Annual Report 2001: Elan. Annual Report , July 09
-
Elan Corp plc: Annual Report 2001: Elan. Annual Report (2002): July 09.
-
(2002)
-
-
-
30
-
-
0034634580
-
Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes
-
Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, Luchian T, Adams DJ, Bond T, Thomas L, Jones A et al: Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J Biol Chem (2000) 275(45):35335- 35344.
-
(2000)
J Biol Chem
, vol.275
, Issue.45
, pp. 35335-35344
-
-
Lewis, R.J.1
Nielsen, K.J.2
Craik, D.J.3
Loughnan, M.L.4
Adams, D.A.5
Sharpe, I.A.6
Luchian, T.7
Adams, D.J.8
Bond, T.9
Thomas, L.10
Jones, A.11
-
31
-
-
0037144134
-
Actions of intrathecal ω-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat
-
Scott DA, Wright CE, Angus JA: Actions of intrathecal ω-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. Eur J Pharmacol (2002) 451(3):279-286.
-
(2002)
Eur J Pharmacol
, vol.451
, Issue.3
, pp. 279-286
-
-
Scott, D.A.1
Wright, C.E.2
Angus, J.A.3
-
32
-
-
0036217174
-
The novel N-type calcium channel blocker, AM336, produces potent dosedependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices
-
Smith MT, Cabot PJ, Ross FB, Robertson AD, Lewis RJ: The novel N-type calcium channel blocker, AM336, produces potent dosedependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain (2002) 96(1-2):119-127.
-
(2002)
Pain
, vol.96
, Issue.1-2
, pp. 119-127
-
-
Smith, M.T.1
Cabot, P.J.2
Ross, F.B.3
Robertson, A.D.4
Lewis, R.J.5
-
33
-
-
0037423378
-
ω-Conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals
-
Adams DJ, Smith AB, Schroeder CI, Yasuda T, Lewis RJ: ω-Conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. J Biol Chem (2003) 278(6):4057-4062.
-
(2003)
J Biol Chem
, vol.278
, Issue.6
, pp. 4057-4062
-
-
Adams, D.J.1
Smith, A.B.2
Schroeder, C.I.3
Yasuda, T.4
Lewis, R.J.5
-
34
-
-
14344249107
-
Emerging analgesics in cancer pain management
-
Radbruch L, Elsner F: Emerging analgesics in cancer pain management. Exp Opin Emerging Drugs (2005) 10(1):151-171.
-
(2005)
Exp Opin Emerging Drugs
, vol.10
, Issue.1
, pp. 151-171
-
-
Radbruch, L.1
Elsner, F.2
-
35
-
-
33747372837
-
The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1
-
Clark RJ, Fischer H, Nevin ST, Adams DJ, Craik DJ: The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1. J Biol Chem (2006) 281(32):23254-23263.
-
(2006)
J Biol Chem
, vol.281
, Issue.32
, pp. 23254-23263
-
-
Clark, R.J.1
Fischer, H.2
Nevin, S.T.3
Adams, D.J.4
Craik, D.J.5
-
36
-
-
26844476004
-
α-Conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones
-
Satkunanathan N, Livett B, Gayler K, Sandall D, Down J, Khalil Z: α-Conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones. Brain Res (2005) 1059(2):149-158.
-
(2005)
Brain Res
, vol.1059
, Issue.2
, pp. 149-158
-
-
Satkunanathan, N.1
Livett, B.2
Gayler, K.3
Sandall, D.4
Down, J.5
Khalil, Z.6
-
37
-
-
34347336966
-
ACV1, enters phase 2 clinical trials
-
Metabolic Pharmaceuticals Ltd: Metabolic's neuropathic pain drug, September 28
-
Metabolic Pharmaceuticals Ltd: Metabolic's neuropathic pain drug, ACV1, enters phase 2 clinical trials. Press Release (2006): September 28
-
(2006)
Press Release
-
-
-
38
-
-
20444381342
-
-
Metabolic Pharmaceuticals Ltd: Metabolic's phase 1 clinical trial demonstrates safety and tolerability of pain drug, November 16
-
Metabolic Pharmaceuticals Ltd: Metabolic's phase 1 clinical trial demonstrates safety and tolerability of pain drug. Press Release (2005): November 16.
-
(2005)
Press Release
-
-
-
39
-
-
33646804559
-
-
Layer RT, McIntosh JM: Conotoxins: Therapeutic potential and application. Mar Drugs (2006) 4(3):119-142. •• A comprehensive review of the pharmaceutical development of conotoxins.
-
Layer RT, McIntosh JM: Conotoxins: Therapeutic potential and application. Mar Drugs (2006) 4(3):119-142. •• A comprehensive review of the pharmaceutical development of conotoxins.
-
-
-
-
40
-
-
27644439887
-
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain
-
Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT: Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain (2005) 118(1-2):112-124.
-
(2005)
Pain
, vol.118
, Issue.1-2
, pp. 112-124
-
-
Nielsen, C.K.1
Lewis, R.J.2
Alewood, D.3
Drinkwater, R.4
Palant, E.5
Patterson, M.6
Yaksh, T.L.7
McCumber, D.8
Smith, M.T.9
-
41
-
-
18944366459
-
-
Xenome Ltd: Xenome's pain drug Xen2174 enters human clinical trials, July 20
-
Xenome Ltd: Xenome's pain drug Xen2174 enters human clinical trials. Press Release (2004): July 20.
-
(2004)
Press Release
-
-
-
42
-
-
20444381342
-
-
Xenome Ltd: Xenome launches multicentre clinical trial for severe cancer pain, November 15
-
Xenome Ltd: Xenome launches multicentre clinical trial for severe cancer pain. Press Release (2005): November 15.
-
(2005)
Press Release
-
-
-
43
-
-
20444381342
-
-
Cognetix Inc: FDA grants orphan drug designation to Cognetix' investigational CGX-1160 for the treatment of chronic intractable pain, August 30
-
Cognetix Inc: FDA grants orphan drug designation to Cognetix' investigational CGX-1160 for the treatment of chronic intractable pain. Press Release (2005): August 30.
-
(2005)
Press Release
-
-
-
44
-
-
34347328608
-
Cognetix announces issuance of
-
US patent on contulakin-G to treat pain; first clinical safety study completed with CGX-1160. Press Release 2002, December 05
-
Cognetix Inc: Cognetix announces issuance of US patent on contulakin-G to treat pain; first clinical safety study completed with CGX-1160. Press Release (2002): December 05.
-
-
-
-
45
-
-
29144455399
-
Chemical synthesis of analogs of the glycopeptide contulakin-G, an analgetically active conopeptide from Conus geographus
-
Westerlind U, Norberg T: Chemical synthesis of analogs of the glycopeptide contulakin-G, an analgetically active conopeptide from Conus geographus. Carbohydr Res (2006) 341(1):9-18.
-
(2006)
Carbohydr Res
, vol.341
, Issue.1
, pp. 9-18
-
-
Westerlind, U.1
Norberg, T.2
-
46
-
-
0033933764
-
Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: In vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies
-
Williams AJ, Dave JR, Phillips JB, Lin Y, McCabe RT, Tortella FC: Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: In vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J Pharmacol Exp Ther (2000) 294(1):378-386.
-
(2000)
J Pharmacol Exp Ther
, vol.294
, Issue.1
, pp. 378-386
-
-
Williams, A.J.1
Dave, J.R.2
Phillips, J.B.3
Lin, Y.4
McCabe, R.T.5
Tortella, F.C.6
-
47
-
-
0037035571
-
Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia
-
Williams AJ, Ling G, McCabe RT, Tortella FC: Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia. Neuroreport (2002) 13(6):821-824.
-
(2002)
Neuroreport
, vol.13
, Issue.6
, pp. 821-824
-
-
Williams, A.J.1
Ling, G.2
McCabe, R.T.3
Tortella, F.C.4
-
48
-
-
0004084141
-
-
Cognetix Inc: Cognetix completes phase I clinical trial of intractable epilepsy treatment, May 30
-
Cognetix Inc: Cognetix completes phase I clinical trial of intractable epilepsy treatment. Press Release (2001): May 30.
-
(2001)
Press Release
-
-
-
49
-
-
18144428396
-
R2B subtype-selective NMDA receptor antagonists: 2001 - 2004
-
McCauley JA: R2B subtype-selective NMDA receptor antagonists: 2001 - 2004. Exp Opin Ther Patents (2005) 15(4):389-407.
-
(2005)
Exp Opin Ther Patents
, vol.15
, Issue.4
, pp. 389-407
-
-
McCauley, J.A.1
-
50
-
-
2342654311
-
The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression
-
Barton ME, White HS: The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression. Epilepsy Res (2004) 59(1):1-12.
-
(2004)
Epilepsy Res
, vol.59
, Issue.1
, pp. 1-12
-
-
Barton, M.E.1
White, H.S.2
-
51
-
-
0035880184
-
Amphiporus alkaloid multiplicity implies functional diversity: Initial studies on crustacean pyridyl receptors
-
Kem WR, Soti F: Amphiporus alkaloid multiplicity implies functional diversity: Initial studies on crustacean pyridyl receptors. Hydrobiologia (2001) 456(1-3):221-231.
-
(2001)
Hydrobiologia
, vol.456
, Issue.1-3
, pp. 221-231
-
-
Kem, W.R.1
Soti, F.2
-
52
-
-
33646758595
-
The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): Chemical and pharmacological properties
-
Kem W, Soti F, Wildeboer K, LeFrancois S, MacDougall K, Wei DQ, Chou KC, Arias HR: The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): Chemical and pharmacological properties. Mar Drugs (2006) 4(3):255-273.
-
(2006)
Mar Drugs
, vol.4
, Issue.3
, pp. 255-273
-
-
Kem, W.1
Soti, F.2
Wildeboer, K.3
LeFrancois, S.4
MacDougall, K.5
Wei, D.Q.6
Chou, K.C.7
Arias, H.R.8
-
54
-
-
33947174540
-
-
Athenagen Inc: Athenagen initiates phase II clinical trial in Alzheimer's disease, December 13
-
Athenagen Inc: Athenagen initiates phase II clinical trial in Alzheimer's disease. Press Release (2006): December 13.
-
(2006)
Press Release
-
-
-
55
-
-
33744911665
-
-
7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry (2006) 63(6):630-638. • The first report on the efficacy of GST-21 in humans.
-
7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry (2006) 63(6):630-638. • The first report on the efficacy of GST-21 in humans.
-
-
-
-
56
-
-
4243536475
-
Ex vivo receptor occupation of GTS-21, a novel nicotinic receptor agonist, in rats
-
Nozawa Y, Nanri M, Kasahara N: Ex vivo receptor occupation of GTS-21, a novel nicotinic receptor agonist, in rats. Jpn J Pharmacol (1996) 71(Suppl 1):176.
-
(1996)
Jpn J Pharmacol
, vol.71
, Issue.SUPPL. 1
, pp. 176
-
-
Nozawa, Y.1
Nanri, M.2
Kasahara, N.3
-
57
-
-
0028934741
-
Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21
-
Arendash GW, Sengstock GJ, Sanberg PR, Kem WR: Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res (1995) 674(2):252-259.
-
(1995)
Brain Res
, vol.674
, Issue.2
, pp. 252-259
-
-
Arendash, G.W.1
Sengstock, G.J.2
Sanberg, P.R.3
Kem, W.R.4
-
58
-
-
0033626286
-
-
7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: Studies with DMXBA (GTS-21). Behav Brain Res (2000) 113(1-2):169-181. •• A comprehensive review of the involvement of nicotinic receptors in AD, and the discovery and optimization of GST-21.
-
7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: Studies with DMXBA (GTS-21). Behav Brain Res (2000) 113(1-2):169-181. •• A comprehensive review of the involvement of nicotinic receptors in AD, and the discovery and optimization of GST-21.
-
-
-
-
59
-
-
0038690569
-
Safety, pharmokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers
-
Kitagawa H, Takenouchi T, Azuma R, Wesnes KA, Kramer WG, Clody DE, Burnett AL: Safety, pharmokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology (2003) 28(3):542-551.
-
(2003)
Neuropsychopharmacology
, vol.28
, Issue.3
, pp. 542-551
-
-
Kitagawa, H.1
Takenouchi, T.2
Azuma, R.3
Wesnes, K.A.4
Kramer, W.G.5
Clody, D.E.6
Burnett, A.L.7
-
61
-
-
9144251593
-
Hydroxy metabolites of the Alzheimer's drug candidate GTS-21: Their molecular properties, interactions with brain nicotinic receptors, and brain penetration
-
Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F: Hydroxy metabolites of the Alzheimer's drug candidate GTS-21: Their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Mol Pharmacol (2004) 65(1):56-67.
-
(2004)
Mol Pharmacol
, vol.65
, Issue.1
, pp. 56-67
-
-
Kem, W.R.1
Mahnir, V.M.2
Prokai, L.3
Papke, R.L.4
Cao, X.5
LeFrancois, S.6
Wildeboer, K.7
Prokai-Tatrai, K.8
Porter-Papke, J.9
Soti, F.10
-
62
-
-
27744476837
-
Theoretical studies of Alzheimer's disease drug candidate 3-[(2,4-dimethoxy)-benzylidene]-anabaseine (GTS-21) and its derivatives
-
Wei DQ, Sirois S, Du QS, Arias HR, Chou KC: Theoretical studies of Alzheimer's disease drug candidate 3-[(2,4-dimethoxy)-benzylidene]-anabaseine (GTS-21) and its derivatives. Biochem Biophys Res Commun (2005) 338(2):1059-1064.
-
(2005)
Biochem Biophys Res Commun
, vol.338
, Issue.2
, pp. 1059-1064
-
-
Wei, D.Q.1
Sirois, S.2
Du, Q.S.3
Arias, H.R.4
Chou, K.C.5
-
63
-
-
3142761435
-
7 Nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia
-
7 Nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia. Psychopharmacology (2004) 174(1):54-64.
-
(2004)
Psychopharmacology
, vol.174
, Issue.1
, pp. 54-64
-
-
Martin, L.F.1
Kem, W.R.2
Freedman, R.3
-
64
-
-
30744443800
-
7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP in β-amyloid infused rats
-
7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP in β-amyloid infused rats. Neuropharmacology (2006) 50(2):254-268.
-
(2006)
Neuropharmacology
, vol.50
, Issue.2
, pp. 254-268
-
-
Chen, L.1
Yamada, K.2
Nabeshima, T.3
Sokabe, M.4
-
65
-
-
17244377332
-
ω-3 Fatty acids and neuropsychiatric disorders
-
Young G, Conquer J: ω-3 Fatty acids and neuropsychiatric disorders. Reprod Nutr Dev (2005) 45(1):1-28.
-
(2005)
Reprod Nutr Dev
, vol.45
, Issue.1
, pp. 1-28
-
-
Young, G.1
Conquer, J.2
-
66
-
-
33745790887
-
Are neurodegenerative disorder and psychotic manifestations avoidable brain dysfunctions with adequate dietary ω-3?
-
Saugstad LF: Are neurodegenerative disorder and psychotic manifestations avoidable brain dysfunctions with adequate dietary ω-3? Nutr Health (2006) 18(2):89-101.
-
(2006)
Nutr Health
, vol.18
, Issue.2
, pp. 89-101
-
-
Saugstad, L.F.1
-
67
-
-
33747180133
-
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on β-amyloid accumulation in APP/PS1 transgenic mice
-
Oksman M, Iivonen H, Hogyes E, Amtul Z, Penke B, Leenders I, Broersen L, Lutjohann D, Hartmann T, Tanila H: Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on β-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol Dis (2006) 23(3):563-572.
-
(2006)
Neurobiol Dis
, vol.23
, Issue.3
, pp. 563-572
-
-
Oksman, M.1
Iivonen, H.2
Hogyes, E.3
Amtul, Z.4
Penke, B.5
Leenders, I.6
Broersen, L.7
Lutjohann, D.8
Hartmann, T.9
Tanila, H.10
-
68
-
-
84947313609
-
-
Alonso D, Martinez A: Marine compounds as a new source for glycogen synthase kinase-3 inhibitors. In: Glycogen Synthase Kinase 3 (GSK-3) and its Inhibitors: Drug Discovery and Development. Martinez A, Castro A, Medina M (Eds), Wiley-VCH Verlag GmbH & Co KGaA, Berlin, Germany (2006):307-331. • New possibilities for marine compounds and their therapeutic application are described.
-
Alonso D, Martinez A: Marine compounds as a new source for glycogen synthase kinase-3 inhibitors. In: Glycogen Synthase Kinase 3 (GSK-3) and its Inhibitors: Drug Discovery and Development. Martinez A, Castro A, Medina M (Eds), Wiley-VCH Verlag GmbH & Co KGaA, Berlin, Germany (2006):307-331. • New possibilities for marine compounds and their therapeutic application are described.
-
-
-
-
69
-
-
0036273020
-
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
-
Martinez A, Castro A, Dorronsoro I, Alonso M: Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med Res Rev (2002) 22(4):373-384.
-
(2002)
Med Res Rev
, vol.22
, Issue.4
, pp. 373-384
-
-
Martinez, A.1
Castro, A.2
Dorronsoro, I.3
Alonso, M.4
-
70
-
-
1642286981
-
GSK-3 inhibitors: Discoveries and developments
-
Alonso M, Martinez A: GSK-3 inhibitors: Discoveries and developments. Curr Med Chem (2004) 11(6):755-763.
-
(2004)
Curr Med Chem
, vol.11
, Issue.6
, pp. 755-763
-
-
Alonso, M.1
Martinez, A.2
-
71
-
-
0034010742
-
Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent
-
Meijer L, Thunnissen AMWH, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J et al: Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol (2001) 7(1):51-63.
-
(2001)
Chem Biol
, vol.7
, Issue.1
, pp. 51-63
-
-
Meijer, L.1
Thunnissen, A.M.W.H.2
White, A.W.3
Garnier, M.4
Nikolic, M.5
Tsai, L.H.6
Walter, J.7
Cleverley, K.E.8
Salinas, P.C.9
Wu, Y.Z.10
Biernat, J.11
-
72
-
-
1542509425
-
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
-
Gompel M, Leost M, de Kier Joffe EB, Puricelli L, Franco LH, Palermo J, Meijer L: Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum. Bioorg Med Chem Lett (2004) 14(7):1703-1707.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, Issue.7
, pp. 1703-1707
-
-
Gompel, M.1
Leost, M.2
de Kier Joffe, E.B.3
Puricelli, L.4
Franco, L.H.5
Palermo, J.6
Meijer, L.7
-
73
-
-
0346875916
-
GSK-3-selective inhibitors derived from Tyrian purple indirubins
-
Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C et al: GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol (2003) 10(12):1255-1266.
-
(2003)
Chem Biol
, vol.10
, Issue.12
, pp. 1255-1266
-
-
Meijer, L.1
Skaltsounis, A.L.2
Magiatis, P.3
Polychronopoulos, P.4
Knockaert, M.5
Leost, M.6
Ryan, X.P.7
Vonica, C.A.8
Brivanlou, A.9
Dajani, R.10
Crovace, C.11
-
74
-
-
33747439379
-
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases
-
Rao KV, Donia MS, Peng J, Garcia-Palomero E, Alonso D, Martinez A, Medina M, Franzblau SG, Tekwani BL, Khan SI, Wahyuono S et al: Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases. J Nat Prod (2006) 69(7):1034-1040.
-
(2006)
J Nat Prod
, vol.69
, Issue.7
, pp. 1034-1040
-
-
Rao, K.V.1
Donia, M.S.2
Peng, J.3
Garcia-Palomero, E.4
Alonso, D.5
Martinez, A.6
Medina, M.7
Franzblau, S.G.8
Tekwani, B.L.9
Khan, S.I.10
Wahyuono, S.11
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