Allosteric regulation of tryptophan synthase channeling: The internal aldimine probed by trans-3-indole-3′-acrylate binding

Biochemistry

Volumn 46, Issue 26, 2007, Pages 7728-7739

  Casino, Patricia ^a,c   Niks, Dimitri ^a   Ngo, Huu ^a   Pan, Peng ^a   Brzovic, Peter ^a,d   Blumenstein, Lars ^b   Barends, Thomas Reinier ^b   Schlichting, Ilme ^b   Dunn, Michael F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c UNIVERSITY OF VALENCIA   (Spain)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDIMINE; ALLOSTERIC INTERACTIONS; SALMONELLA TYPHIMURIUM;

BACTERIA; BINDING SITES; EMISSION SPECTROSCOPY; LIGANDS; X RAY CRYSTALLOGRAPHY;

ENZYMES;

2 AMINOETHYLPHOSPHONIC ACID; 3 INDOLE 3' ACRYLATE; ALDIMINE; ANISOLE; BENZENESULFONIC ACID DERIVATIVE; DEHYDROALANINE; GLYCERALDEHYDE 3 PHOSPHATE; GLYCEROPHOSPHATE; IMINE; N (4' TRIFLUOROMETHOXYBENZENESULFONYL) 2 AMINOETHYL PHOSPHATE; N (4' TRIFLUOROMETHOXYBENZOYL) 2 AMINOETHYL PHOSPHATE; QUINONE DERIVATIVE; TRYPTOPHAN SYNTHASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING AFFINITY; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME REGULATION; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPECTRUM; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BINDING SITES; CIRCULAR DICHROISM; CRYSTALLIZATION; INDOLES; KINETICS; PROTEIN CONFORMATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPTOPHAN SYNTHASE;

SALMONELLA TYPHIMURIUM;

EID: 34347327186     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700386b     Document Type: Article

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