Requirement of Apaf-1 for mitochondrial events and the cleavage or activation of all procaspases during genotoxic stress-induced apoptosis

Biochemical Journal

Volumn 405, Issue 1, 2007, Pages 115-122

  Franklin, Emily E ^a   Robertson, John D ^a  

^a UNIVERSITY OF KANSAS CANCER CENTER   (United States)

Author keywords

Caspase; Cytochrome c; DNA damage; Fas; Jurkat cell; Mitochondrial outer membrane permeabilization (MOMP)

Indexed keywords

APOPTOTIC EVENTS; CASPASE; CYTOCHROME C; DNA DAMAGE; GENOTOXIC DRUGS; JURKAT CELL; MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION (MOMP);

ACTIVATION ANALYSIS; BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CELL DEATH; GENE EXPRESSION; TOXICITY;

ENZYME ACTIVITY;

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BH3 PROTEIN; CASPASE; CASPASE 2; CYSTEINE PROTEINASE; CYTOCHROME C; FAS ANTIBODY; PROCASPASE 2; PROCASPASE 9; PROTEIN BID; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; DNA DAMAGE; ENZYME ACTIVATION; FIBROBLAST; GENOTOXICITY; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 2; CASPASE 9; CELLS, CULTURED; DNA DAMAGE; ENZYME ACTIVATION; ETOPOSIDE; FIBROBLASTS; HUMANS; JURKAT CELLS; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOXANTRONE; RNA INTERFERENCE;

EID: 34347259875     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061576     Document Type: Article

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