Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii

Cancer Letters

Volumn 112, Issue 1, 1997, Pages 113-117

  Shamon, Lisa A ^a   Pezzuto, John M ^a,b   Graves, Jewell M ^b   Mehta, Rajeshwari R ^b   Wangcharoentrakul, Sirichai ^c   Sangsuwan, Ranee ^d   Chaichana, Suttiporn ^d   Tuchinda, Patoomratana ^d   Cleason, Per ^d   Reutrakul, Vichai ^d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c THAILAND CENTER OF EXCELLENCE IN PHYSICS   (Thailand)

^d MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Antitumor activity; Bacterial mutagenesis; Cytotoxicity; Triptolide

Indexed keywords

DITERPENE; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE;

AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; MAMMAL CELL; METABOLIC ACTIVATION; MOUSE; MUTAGENICITY; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MUTAGENICITY TESTS; PHENANTHRENES; SALMONELLA TYPHIMURIUM;

ANIMALIA; BACTERIA (MICROORGANISMS); CELASTRACEAE; MAMMALIA; MUS MUSCULUS; RODENTIA; SALMONELLA TYPHIMURIUM; TRIPTERYGIUM; TRIPTERYGIUM WILFORDII; TYPHIMURIUM;

EID: 0031024058     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(96)04554-5     Document Type: Article

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