Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo

Anesthesiology

Volumn 104, Issue 6, 2006, Pages 1266-1273

  Lirk, Philipp ^a   Haller, Ingrid ^a   Myers, Robert R ^c   Klimaschewski, Lars ^b   Kau, Yi Chuan ^d   Hung, Yu Chun ^d   Gerner, Peter ^d,e  

^a Department of Anesthesiology and Critical Care Medicine ^*

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e Pain Research Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMITRIPTYLINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LOCAL ANESTHESIA; MICROSCOPY; NERVE BLOCK; NERVE CELL CULTURE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SENSORY NERVE CELL; SPINAL GANGLION; STATISTICAL SIGNIFICANCE;

AMITRIPTYLINE; ANESTHETICS, LOCAL; ANIMALS; APOPTOSIS; CELLS, CULTURED; ENZYME INHIBITORS; FEMALE; GANGLIA, SPINAL; IMIDAZOLES; LIDOCAINE; MEMBRANE POTENTIALS; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE;

EID: 33744959001     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200606000-00023     Document Type: Article

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