Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides

Biochemistry

Volumn 46, Issue 25, 2007, Pages 7437-7448

  Palaniappan, Krishnan K ^a   Gao, Zhan Guo ^a   Ivanov, Andrei A ^a   Greaves, Rebecca ^a   Adachi, Hayamitsu ^a   Besada, Pedro ^a   Hea, Ok Kim ^b   Ae, Yil Kim ^b   Seung, Ah Choe ^b   Lak, Shin Jeong ^b   Jacobson, Kenneth A ^a,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b Ewha Womans University   (South Korea)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; MUTANT RECEPTORS; MUTATION; NUCLEOSIDES;

CALCIUM; MOLECULAR DYNAMICS; MUTAGENESIS; NUCLEOTIDES; PROTEINS;

AMINES;

ADENOSINE A1 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; ASPARTIC ACID; CALCIUM; DEOXYADENOSINE; G PROTEIN COUPLED RECEPTOR; HISTIDINE; HYDROXYL GROUP; MUTANT PROTEIN; N6 CYCLOPENTYL 3' UREIDO 3' DEOXYADENOSINE; NUCLEOSIDE; RHODOPSIN; THREONINE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM MOBILIZATION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CALCIUM; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; GENETIC ENGINEERING; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NUCLEOSIDES; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A1; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 34250830238     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7001828     Document Type: Article

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