N6-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands

Journal of Medicinal Chemistry

Volumn 45, Issue 15, 2002, Pages 3271-3279

  Volpini, Rosaria ^a   Costanzi, Stefano ^a   Lambertucci, Catia ^a   Taffi, Sara ^a   Vittori, Sauro ^a   Klotz, Karl Norbert ^b   Cristalli, Gloria ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYLHYDROXYPROPYNYLADENOSINE 5' (N ETHYLCARBOXAMIDE); 6 N ETHYL 2 (3 HYDROXY 3 PHENYL 1 PROPYN 1 YL)ADENOSINE; 6 N METHYL 2 PHENYLETHYNYLADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE) DERIVATIVE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR AFFECTING AGENT; ALIPHATIC AMINE; METHYL GROUP; RADIOLIGAND; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ADENYLATE CYCLASE; ALKYNES; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037130186     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0109762     Document Type: Article

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