Abetalipoproteinemia induced by overexpression of ORP150 in mice

Comparative Medicine

Volumn 57, Issue 3, 2007, Pages 247-254

  Kobayashi, Tomohiro ^a   Iguchi, Taisen ^b   Ohta, Yasuhiko ^c  

^a Kyoto University   (Japan)

^b OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CHYLOMICRON; GLUCOSE; INSULIN; PROTEIN; PROTEIN ORP150; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ABETALIPOPROTEINEMIA; AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; GROWTH RETARDATION; INSULIN BLOOD LEVEL; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

ABETALIPOPROTEINEMIA; ANIMALS; BODY WEIGHT; DIETARY FATS; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEINS; TRIGLYCERIDES;

EID: 34250818723     PISSN: 15320820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Argon Y, Simen BB. 1999. GRP94, an ER chaperone with protein and peptide binding properties. Semin Cell Dev Biol 10:495-505.
2. Bando Y, Ogawa S, Yamauchi A, Kuwabara K, Ozawa K, Hori O, Yanagi H, Tamatani M, Tohyama M. 2000. 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells. Am J Physiol Cell Physiol 278:C1172-C1182.
3. Camporeale G, Zempleni J. 2003. Oxidative folding of interleukin-2 is impaired in flavin-deficient Jurkat cells, causing intracellular accumulation of interleukin 2 and increased expression of stress response genes. J Nutr 133:668-672.
4. Chen X, Easton D, Oh HJ, Lee-Yoon DS, Liu X, Subjeck J. 1996. The 170-kDa glucose regulated stress protein is a large HSP70-, HSP110-like protein of the endoplasmic reticulum. FEBS Lett 380:68-72.
5. DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ. 1999. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99:703-712.
6. Glickman RM, Rogers M, Glickman JN. 1986. Apolipoprotein B synthesis by human liver and intestine in vitro. Proc Natl Acad Sci USA 83:5296-5300.
7. Goldstein JL, Rawson RB, Brown MS. 2002. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys 397:139-148.
8. Gray CC, Amrani M, Yacoub MH. 1999. Heat stress proteins and myocardial protection: experimental model or potential clinical tool? Int J Biochem Cell Biol 31:559-573.
9. Gregg RE, Wetterau JR. 1994. The molecular basis of abetalipoproteinemia. Curr Opin Lipidol 5:81-86.
10. Henle KJ, Jethmalani SM, Nagle WA. 1998. Stress proteins and glycoproteins (review). Int J Mol Med 1:25-32.
11. Horton JD, Goldstein JL, Brown MS. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-1131.
12. Horton JD, Shimomura I. 1999. Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol 10:143-150.
13. Hussain MM, Iqbal J, Anwar K, Rava P, Dai K. 2003. Microsomal triglyceride transfer protein: a multifunctional protein. Front Biosci 8:S500-S506.
14. Ikeda J, Kaneda S, Kuwabara K, Ogawa S, Kobayashi T, Matsumoto M, Yura T, Yanagi H. 1997. Cloning and expression of cDNA encoding the human 150-kDa oxygen-regulated protein, ORP150. Biochem Biophys Res Commun 230:94-99.
15. Kitao Y, Ozawa K, Miyazaki M, Tamatani M, Kobayashi T, Yanagi H, Okabe M, Ikawa M, Yamashima T, Stern DM, Hori O, Ogawa S. 2001. Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity. J Clin Invest 108:1439-1450.
16. Kobayashi T, Ogawa S, Yura T, Yanagi H. 2000. Abundant expression of 150-kDa oxygen-regulated protein in mouse pancreatic beta cells is correlated with insulin secretion. Biochem Biophys Res Commun 267:831-837.
17. Kobayashi T, Ohta Y. 2003. Enforced expression of oxygen-regulated protein, ORP150, induces vacuolar degeneration in mouse myocardium. Transgenic Res 12:13-22.
18. Kobayashi T, Ohta Y. 2005. 150-kD oxygen-regulated protein is an essential factor for insulin release. Pancreas 30:299-306.
19. Kobayashi T, Yura T, Yanagi H. 2002. The increment of anti-ORP150 autoantibody in initial stages of atheroma in high-fat diet fed mice. J Vet Med Sci 64:177-180.
20. Kovacs P, Yang X, Permana PA, Bogardus C, Baier LJ. 2002. Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians. Diabetes 51:1618-1621.
21. Kumar GK, Klein JB. 2004. Analysis of expression and posttranslational modification of proteins during hypoxia. J Appl Physiol 96:1178-1186; discussion 1170-1172.
22. Kuwabara K, Matsumoto M, Ikeda J, Hori O, Ogawa S, Maeda Y, Kitagawa K, Imuta N, Kinoshita T, Stern DM, Yanagi H, Kamada T. 1996. Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. J Biol Chem 271:5025-5032.
23. Kuznetsov G, Chen LB, Nigam SK. 1994. Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. J Biol Chem 269:22990-22995.
24. Kuznetsov G, Chen LB, Nigam SK. 1997. Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. J Biol Chem 272:3057-3063.
25. Lee AS. 1981. The accumulation of three specific proteins related to glucose-regulated proteins in a temperature-sensitive hamster mutant cell line K12. J Cell Physiol 106:119-125.
26. Lee AS. 2001. The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26:504-510.
27. Levy E, Stan S, Delvin E, Menard D, Shoulders C, Garofalo C, Slight I, Seidman E, Mayer G, Bendayan M. 2002. Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. J Biol Chem 277:16470-16477.
28. Liao W, Hui TY, Young SG, Davis RA. 2003. Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. J Lipid Res 44:978-985.
29. Lin HY, Masso-Welch P, Di YP, Cai JW, Shen JW, Subjeck JR. 1993. The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin. Mol Biol Cell 4:1109-1119.
30. Linnik KM, Herscovitz H. 1998. Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state. J Biol Chem 273:21368-21373.
31. Little E, Ramakrishnan M, Roy B, Gazit G, Lee AS. 1994. The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit Rev Eukaryot Gene Expr 4:1-18.
32. Manthey KC, Chew YC, Zempleni J. 2005. Riboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems. J Nutr 135:978-982.
33. Meunier L, Usherwood YK, Chung KT, Hendershot LM. 2002. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell 13:4456-4469.
34. Nakatani Y, Kaneto H, Kawamori D, Yoshiuchi K, Hatazaki M, Matsuoka TA, Ozawa K, Ogawa S, Hori M, Yamasaki Y, Matsuhisa M. 2005. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem 280:847-851.
35. Naved AF, Ozawa M, Yu S, Miyauchi T, Muramatsu H, Muramatsu T. 1995. CBP-140, a novel endoplasmic reticulum resident Ca(2+)-binding protein with a carboxy-terminal NDEL sequence showed partial homology with 70-kDa heat shock protein (hsp70). Cell Struct Funct 20:133-141.
36. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y. 1997. 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407:313-319.
37. Oliver JD, Hresko RC, Mueckler M, High S. 1996. The glut 1 glucose transporter interacts with calnexin and calreticulin. J Biol Chem 271:13691-13696.
38. Ozawa K, Kondo T, Hori O, Kitao Y, Stern DM, Eisenmenger W, Ogawa S, Ohshima T. 2001. Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport. J Clin Invest 108:41-50.
39. Ozawa K, Kuwabara K, Tamatani M, Takatsuji K, Tsukamoto Y, Kaneda S, Yanagi H, Stern DM, Eguchi Y, Tsujimoto Y, Ogawa S, Tohyama M. 1999. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. J Biol Chem 274:6397-6404.
40. Ozawa K, Miyazaki M, Matsuhisa M, Takano K, Nakatani Y, Hatazaki M, Tamatani T, Yamagata K, Miyagawa J, Kitao Y, Hori O, Yamasaki Y, Ogawa S. 2005. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 54:657-663.
41. Park J, Easton DP, Chen X, MacDonald IJ, Wang XY, Subjeck JR. 2003. The chaperoning properties of mouse grp170, a member of the third family of hsp70-related proteins. Biochemistry 42:14893-14902.
42. Raabe M, Veniant MM, Sullivan MA, Zlot CH, Bjorkegren J, Nielsen LB, Wong JS, Hamilton RL, Young SG. 1999. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 103:1287-1298.
43. Ricci B, Sharp D, O'Rourke E, Kienzle B, Blinderman L, Gordon D, Smith-Monroy C, Robinson G, Gregg RE, Rader DJ, Wetterau JR. 1995. A 30-amino acid truncation of the microsomal triglyceride transfer protein large subunit disrupts its interaction with protein disulfide-isomerase and causes abetalipoproteinemia. J Biol Chem 270:14281-14285.
44. Rivlin RS. 2001. Riboflavin, 8th ed. Washington (DC): ILSI Press.
45. Sawa T, Imamura T, Haruta T, Sasaoka T, Ishiki M, Takata Y, Takada Y, Morioka H, Ishihara H, Usui I, Kobayashi M. 1996. Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor. Biochem Biophys Res Commun 218:449-453.
46. Sharp D, Blinderman L, Combs KA, Kienzle B, Ricci B, Wager-Smith K, Gil CM, Turck CW, Bouma ME, Rader DJ, Aggerbeck LP, Gregg RE, Gordon DA, Wetterau JR. 1993. Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia. Nature 365:65-69.
47. Shelness GS, Sellers JA. 2001. Very-low-density lipoprotein assembly and secretion. Curr Opin Lipidol 12:151-157.
48. Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N. 1999. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem 274:35832-35839.
49. Spee P, Subjeck J, Neefjes J. 1999. Identification of novel peptide binding proteins in the endoplasmic reticulum: ERp72, calnexin, and grp170. Biochemistry 38:10559-10566.
50. Swift LL, Zhu MY, Kakkad B, Jovanovska A, Neely MD, Valyi-Nagy K, Roberts RL, Ong DE, Jerome WC. 2003. Subcellular localization of microsomal triglyceride transfer protein. J Lipid Res 44:1841-1849.
51. Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, Che YH, Ozawa K, Hori O, Nishimura H, Yamashita A, Okabe M, Yanagi H, Stern DM, Ogawa S, Tohyama M. 2001. ORP150 protects against hypoxia/ischemia-induced neuronal death. Nat Med 7:317-323.
52. Tsukamoto Y, Kuwabara K, Hirota S, Ikeda J, Stern D, Yanagi H, Matsumoto M, Ogawa S, Kitamura Y. 1996. 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low-density lipoprotein. J Clin Invest 98:1930-1941.
53. Tsukamoto Y, Kuwabara K, Hirota S, Kawano K, Yoshikawa K, Ozawa K, Kobayashi K, Yanagi H, Stern DM, Tohyama M, Kitamura Y, Ogawa S. 1998. Expression of the 150-kd oxygen-regulated protein in human breast cancer. Lab Invest 78:699-706.
54. Wang XY, Kazim L, Repasky EA, Subjeck JR. 2003. Immunization with tumor-derived ER chaperone grp170 elicits tumor-specific CD8+ T-cell responses and reduces pulmonary metastatic disease. Int J Cancer 105:226-231.
55. Wetterau JR, Lin MC, Jamil H. 1997. Microsomal triglyceride transfer protein. Biochim Biophys Acta 1345:136-150.
56. Yang J, Goldstein JL, Hammer RE, Moon YA, Brown MS, Horton JD. 2001. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A 98:13607-13612.
57. Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL. 2000. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell 6:1355-1364.