Disparate primary and secondary allospecific CD8+ T cell cytolytic effector function in the presence or absence of host CD4+ T cells

Journal of Immunology

Volumn 179, Issue 1, 2007, Pages 80-88

  Horne, Phillip H ^b   Koester, Mitchel A ^a   Jayashankar, Kartika ^a   Lunsford, Keri E ^b   Dziema, Heather L ^a   Bumgardner, Ginny L ^a,b  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EFFECTOR CELL; GRAFT REJECTION; HEPATOCYTE TRANSPLANTATION; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 34250809525     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.179.1.80     Document Type: Article

References (70)

1. + T-helper and a T-killer cell. Nature 393: 474-477.
2. Bennett, S. R., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393: 478-480.
3. Schoenberger, S. P., R. E. M. Toes, E. I. H. van der Voort, R. Offringa, and C. J. M. Melief. 1998. T-cell help for cytotoxic T lymphoctes is mediated by CD40-CD40L interactions. Nature 393: 480-483.
4. Lanzavecchia, A. 1998. Immunology: license to kill. Nature 393: 413-414.
5. + T cells during Cryptococcus neoformans infection. J. Immunol. 174: 7920-7928.
6. + T cell help. J. Immunol. 165: 5177-5185.
7. + T cells generated depends on the nature of the initial nonspecific stimulation. Eur. J. Immunol. 32: 1541-1549.
8. Buller, R. M. L., K. L. Holmes, A. Hugin, T. N. Frederickson, and H. C. Morse. 1987. Induction of cytotoxic T-cell response in vivo in the absence of CD4 helper cells. Nature 328: 77-79.
9. + T-cell responses. Curr. Biol. 4: 499-505.
10. + T cell responses in the liver. Hepatology 40: 300-309.
11. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300: 339-342.
12. + T lymphocytes. Nature 421: 852-856.
13. + T cells after acute infection. Nat. Immunol. 5: 927-933.
14. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339.
15. Khanolkar, A., M. J. Fuller, and A. J. Zajac. 2004. CD4 T cell-dependent CD8 T cell maturation. J. Immunol. 172: 2834-2844.
16. + T-cell response. Nat. Rev. Immunol. 4: 595-602.
17. + T lymphocytes. Nature 421: 852-856.
18. + T-cell differentiation in the context of infection. Immunol. Rev. 211: 197-202.
19. Masopust, D., S. M. Kaech, E. J. Wherry, and R. Ahmed. 2004. The role of programming in memory T-cell development. Curr. Opin. Immunol. 16: 217-225.
20. Northrop, J. K., R. M. Thomas, A. D. Wells, and H. Shen. 2006. Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells. J. Immunol. 177: 1062-1069.
21. + effectors in promoting tubular injury following allogeneic renal transplantation. J. Immunol. 175: 2868-2879.
22. + T cells. J. Exp. Med. 196: 877-886.
23. + T cell subsets TC1 and TC2 cause different histopathologic forms of murine cardiac allograft rejection. Transplantation 71: 606-610.
24. -/- mice independent of the CD40/ CD40L costimulatory pathway. Transpl. Immunol. 9: 13-17.
25. + T cells: there's more to it than MHC restriction. Am. J. Transplant. 3: 107-115.
26. Bumgardner, G. L., and C. G. Orosz. 2000. Unusual patterns of alloimmunity evoked by allogeneic liver parenchymal cells. Immunol. Rev. 174: 260-279.
27. Bumgardner, G. L., D. Gao, J. Li, J. Baskin, M. Heininger, and C. G. Orosz. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4 KO, and CD8 KO mice. Transplantation 70: 1771-1780.
28. Ninova, D., P. G. Dean, M. Deeds, and M. D. Stegall. 2005. A novel model of allograft rejection: immune reconstitution of Rag-1 recipients with 2C transgenic T-cell receptor lymphocytes. Transpl. Int. 18: 101-110.
29. + T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. J. Immunol. 170: 3024-3028.
30. Meng, L., Z. Guo, O. Kim, G. He, J. Hart, G. L. Szot, J. Wang, T. C. Pearson, C. P. Larsen, and K. A. Newell. 2001. Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejection. Transplant. Proc. 33: 418-420.
31. + T cells. J. Immunol. 163: 2358-2362.
32. + cells and CD40-CD40 ligand interactions. J. Immunol. 166: 3248-3255.
33. Bumgardner, G. L., J. Li, M. Heininger, and C. G. Orosz. 1998. Costimulation pathways in host immune responses to allogeneic hepatocytes. Transplantation 66: 1841-1845.
34. + cells that independently initiate rejection of allogeneic hepatocytes in mice. Hepatology 32: 1018-1028.
35. + T cells. Am. J. Transplant. 3: 543-551.
36. + T-cell responses in acute rejection. Transplantation 68: 555-562.
37. Wang, Y., D. Gao, K. E. Lunsford, W. L. Frankel, and G. L. Bumgardner. 2003. Targeting LFA-1 synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection. Am. J. Transplant. 3: 1251-1258.
38. He, G., J. Hart, O. S. Kim, G. L. Szot, C. T. Siegel, J. R. Thistlethwaite, and K. A. Newell. 1999. The role of CD8 and CD4 T cells in intestinal allograft rejection: a comparison of monoclonal antibody-treated and knockout mice. Transplantation 67: 131-137.
39. + T cells play a critical role in costimulation blockade-resistant allograft rejection. J. Clin. Invest. 104: 1715-1722.
40. Han, W. R., Y. Zhan, L. J. Murray-Segal, J. L. Brady, A. M. Lew, and P. L. Mottram. 2000. Prolonged allograft survival in anti-CD4 antibody transgenic mice: lack of residual helper T cells compared with other CD4-deficient mice. Transplantation 70: 168-174.
41. + T cells can trigger allograft rejection. J. Immunol. 165: 1111-1118.
42. + T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection. Transplantation 11: 1815-1820.
43. Habiro, K., M. Kotani, K. Omoto, S. Kobayashi, K. Tanabe, H. Shimmura, K. Suzuki, T. Hayashi, H. Toma, and R. Abe. 2003. Mechanism of allorecognition and skin graft rejection in CD28 and CD40 ligand double-deficient mice. Transplantation 76: 854-858.
44. Ferrari-Lacraz, S., X. X. Zheng, Y. S. Kim, Y. Li, W. Maslinski, X. C. Li, and T. B. Strom. 2001. An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection. J. Immunol. 167: 3478-3485.
45. Filatenkov, A. A., E. L. Jacovetty, U. B. Fischer, J. M. Curtsinger, M. F. Mescher, and E. Ingulli. 2005. CD4 T cell-dependent conditioning of dendritic cells to produce IL-12 results in CD8-mediated graft rejection and avoidance of tolerance. J. Immunol. 174: 6909-6917.
46. + cytolytic T cells. Am. J. Transplant. 6: 2268-2281.
47. + T cells. J. Immunol. 175: 7855-7866.
48. Bumgardner, G. L., M. Heininger, J. Li, D. Xia, J. Parker-Thornburg, R. M. Ferguson, and C. G. Orosz. 1998. A functional model of hepatocyte transplantation for in vivo immunologic studies. Transplantation 65: 53-61.
49. + T lymphocyte responses. Nat. Immunol. 4: 361-365.
50. Oehen, S., and K. Brduscha-Riem. 1998. Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J. Immunol. 161: 5338-5346.
51. + T cell function but not expansion. Nat. Immunol. 3: 1208-1213.
52. Mintem, J. D., G. M. Davey, G. T. Belz, F. R. Carbone, and W. R. Heath. 2002. Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells. J. Immunol. 168: 977-980.
53. + T lymphocytes. J. Immunol. 151: 5993-6001.
54. Gomard, E., J. Wybier-Franqui, M. C. Simmler, I. F. McKenzie, and J. P. Levy. 1981. Accessory cells in the in vitro generation of type C virus-specific T killer lymphocytes. II. Demonstration of a T helper cell in the spleen of in vivo primed mice. J. Immunol. 127: 2291-2295.
55. Gualde, N., O. Weinberger, S. Ratnofsky, B. Benacerraf, and S. J. Burakoff. 1982. In vitro generation of helper T cells and suppressor T cells that regulate the cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells. Transplantation 33: 422-426.
56. Wolos, J. A., and J. B. Smith. 1981. Helper cells in the autologous mixed lymphocyte reaction. I. Generation of cytotoxic T cells recognizing modified self H-2. J. Immunol. 127: 711-715.
57. + murine T cells. I. Development of cytolytic activity. Immunol. Res. 13: 215-233.
58. Ciavarra, R. P. 1991. T helper cells in cytotoxic T lymphocyte development: analysis of the cellular basis for deficient T helper cell function in the L3T4-independent T helper cell pathway. Cell. Immunol. 134: 427-441.
59. Widmer, M. B., and F. H. Bach. 1983. Antigen specificity and helper characteristics of antigen-driven helper-cell-independent cytolytic T lymphocytes. Transplantation 36: 565-567.
60. Ehst, B. D., E. Ingulli, and M. K. Jenkins. 2003. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am. J. Transplant. 3: 1355-1362.
61. + T-cell-independent pathway for antitumor CTL induction. Blood 106: 338-344.
62. Kean, L. S., K. Hamby, B. Koehn, E. Lee, S. Coley, L. Stempora, A. B. Adams, E. Heiss, T. C. Pearson, and C. P. Larsen. 2006. NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation. Am. J. Transplant. 6: 292-304.
63. + T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434: 88-93.
64. Zhan, Y., A. J. Corbett, J. L. Brady, R. M. Sutherland, and A. M. Lew. 2000. CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation. J. Immunol. 165: 3612-3619.
65. Tham, E. L., P. Shrikant, and M. F. Mescher. 2002. Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response. J. Immunol. 168: 1190-1197.
66. Russell, J. H., and T. J. Ley. 2002. Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20: 323-370.
67. Heusel, J. W., R. L. Wesselschmidt, S. Shresta, J. H. Russell, and T. J. Ley. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76: 977-987.
68. Kojima, H., M. Toda, and M. V. Sitkovsky. 2000. Comparison of Fas-versus perforin-mediated pathways of cytotoxicity in TCR- and Thy-1-activated murine T cells. Int. Immunol. 12: 365-374.
69. + T cell immunity. Nat. Immunol. 5: 1143-1148.
70. Badovinac, V. P., K. A. Messingham, T. S. Griffith, and J. T. Harty. 2006. TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells. J. Immunol. 177: 999-1006.