Activation and maturation of alloreactive CD4-independent, CD8+ cytolytic T cells

American Journal of Transplantation

Volumn 6, Issue 10, 2006, Pages 2268-2281

  Lunsford, K E ^a   Horne, P H ^a   Koester, M A ^b   Eiring, A M ^b   Walker, J P ^b   Dziema, H L ^b   Bumgardner, G L ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

CD8+ T cell; Cytotoxic effector; Graft infiltrating cells; Hepatocyte; Islet; Tissue specific factors

Indexed keywords

CD103 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD69 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; LEUKOSIALIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GRAFT REJECTION; HEPATOCYTE TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; GRAFT REJECTION; HEPATOCYTES; IMMUNITY, CELLULAR; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 33748501300     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01479.x     Document Type: Article

References (55)

1. + T cells: There's more to it than MHC restriction. Am J Transplant 2003; 3: 107-115.
2. Le Moine A, Goldman M. Non-classical pathways of cell-mediated allograft rejection: New challenges for tolerance induction? Am J Transplant 2003; 3: 101-106.
3. Bumgardner GL, Gao D, Li J, Baskin J, Heininger M, Orosz CG. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4 KO, and CD8 KO mice. Transplantation 2000; 70: 1771-1780.
4. + T-cell responses in acute rejection. Transplantation 1999; 68: 555-562.
5. Wang Y, Gao D, Lunsford KE, Frankel WL, Bumgardner GL. Targeting LFA-1 synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection. Am J Transplant 2003; 3: 1251-1258.
6. + T cells in intestinal allograft rejection: A comparison of monoclonal antibody-treated and knockout mice. Transplantation 1999; 67: 131-137.
7. + T cells. J Immunol 1999; 163: 2358-2362.
8. + T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest 1999; 104: 1715-1722.
9. Han WR, Zhan Y, Murray-Segal LJ, Brady JL, Lew AM, Mottram PL. Prolonged allograft survival in anti-CD4 antibody transgenic mice: Lack of residual helper T cells compared with other CD4-deficient mice. Transplantation 2000; 70: 168-174.
10. + T cells can trigger allograft rejection. J Immunol 2000; 165: 1111-1118.
11. + cells and CD40-CD40 Ligand interactions. J Immunol 2001; 166: 3248-3255.
12. Bumgardner GL, Gao D, Li J, Bickerstaff A, Orosz C. MHC-identical heart and hepatocyte allografts evoke opposite immune responses within the same host. Transplantation 2002; 74: 855-864.
13. Guo Z, Meng L, Kim O et al. CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway. Transplantation 2001; 71: 1351-1354.
14. + T cells and prolonged graft survival in a CTLA4-dependent manner. J Immunol 2000; 164: 512-521.
15. + cells that independently initiate rejection of allogeneic hepatocytes in mice. Hepatology 2000; 32: 1018-1028.
16. Lunsford KE, Gao D, Eiring AM, Wang Y, Frankel WL, Bumgardner GL. Evidence for tissue directed immune responses: Analysis of CD4-dependent and CD8-dependent alloimmunity. Transplantation 2004; 78: 1125-1133.
17. + T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection. Transplantation 2004; 77: 1815-1820.
18. + T cells generated in response to viral infections. J Immunol 2003; 170: 4077-4086.
19. + T-cell deletion induced by costimulation blockade. J Surg Res 2000; 93: 63-69.
20. Forman D, Welsh RM, Markees TG et al. Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms. J Immunol 2002; 168: 6047-6056.
21. Han D, Xu X, Pastori RL, Ricordi C, Kenyon NS. Elevation of cytotoxic lymphocyte gene expression is predictive of islet allograft rejection in nonhuman primates. Diabetes 2002; 51: 562-566.
22. Bumgardner GL, Heininger M, Li J et al. A functional model of hepatocyte transplantation for in vivo immunologic studies. Transplantation 1998; 65: 53-61.
23. Crispe IN. Isolation of mouse intrahepatic lymphocytes. In: Coligan JE, Kroisbeek AM, Margulies DH, Shevach EM, Straber W (eds). Current Protocols in Immunology. New York: John Wiley & Sons; 1997:pp. 3.21.1-3.21.8.
24. + T cells. J Immunol 2005; 175: 7855-7866.
25. Bumgardner GL, Li J, Apte S, Heininger M, Frankel WL. Effect of tumor necrosis factor α and intercellular adhesion molecule-1 expression on immunogenicity of murine liver cells in mice. Hepatology 1998; 28: 466-474.
26. de Fries R, Mitsuhashi M. Quantification of mitogen induced human lymphocyte proliferation: Comparison of alamarBlue assay to 3H-thymidine incorporation assay. J Clin Lab Anal 1995; 9: 89-95.
27. + T lymphocyte responses. Nat Immunol 2003; 4: 361-365.
28. Oehen S, Brduscha-Riem K. Differentiation of naive CTL to effector and memory CTL: Correlation of effector function with phenotype and cell division. J Immunol 1998; 161: 5338-5346.
29. Bumgardner GL, Orosz CG. Unusual patterns of alloimmunity evoked by allogeneic liver parenchymal cells. Immunol Rev 2000; 174: 260-279.
30. Feng Y, Wang D, Yuan R, Parker CM, Farber DL, Hadley GA. CD103 expression is required for destruction of pancreatic islet allografts by CD8+ T cells. J Exp Med 2002; 196: 877-886.
31. + T cells by altered expression of cell surface O-glycans. J Exp Med 2000; 191: 1241-1246.
32. Sacks D, Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2002; 2: 845-858.
33. Koulmanda M, Qipo A, Auchincloss H Jr, Smith RN. Effects of streptozotocin on autoimmune diabetes in NOD mice. Clin Exp Immunol 2003; 134: 210-216.
34. Doherty DG, O'Farrelly C. Innate and adaptive lymphoid cells in the human liver. Immunol Rev 2000; 174: 5-20.
35. Hayday AC. γδ cells: A right time and a right place for a conserved third way of protection. Annu Rev Immunol 2000; 18: 975-1026.
36. Park SH, Weiss A, Benlagha K, Kyin T, Teyton L, Bendelac A. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J Exp Med 2001; 193: 893-904.
37. Wang T, Scully E, Yin Z et al. IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. J Immunol 2003; 171: 2524-2531.
38. Matsuda JL, Naidenko OV, Gapin L et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med 2000; 192: 741-754.
39. Gao Y, Yang W, Pan M et al. Gamma delta T cells provide an early source of interferon gamma in tumor immunity. J Exp Med 2003; 198: 433-442.
40. + T cell immune response against Encephalitozoon cuniculi infection. J Immunol 2001; 166: 7389-7397.
41. Kronenberg M. Toward an understanding of NKT cell biology: Progress and paradoxes. Annu Rev Immunol 2005; 23: 877-900.
42. Porcelli SA, Modlin RL. The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 1999; 17: 297-329.
43. Bleicher PA, Balk SP, Hagen SJ, Blumberg RS, Flotte TJ, Terhorst C. Expression of murine CD1 on gastrointestinal epithelium. Science 1990; 250: 679-682.
44. Canchis PW, Bhan AK, Landau SB, Yang L, Balk SP, Blumberg RS. Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d. Immunology 1993; 80: 561-565.
45. Durante-Mangoni E, Wang R, Shaulov A et al. Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. J Immunol 2004; 173: 2159-2166.
46. + T cells in human livers; its association with extrathymic T cells. J Hepatol 2003; 39: 918-924.
47. Kommajosyula S, Reddy S, Nitschke K, Kanwar JR, Karanam M, Krissansen GW. Leukocytes infiltrating the pancreatic islets of nonobese diabetic mice are transformed into inactive exiles by combinational anti-cell adhesion therapy. J Leukoc Biol 2001; 70: 510-517.
48. + CTL. J Immunol 1997; 159: 3748-3756.
49. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.
50. Ziegler SF, Ramsdell F, Alderson MR. The activation antigen CD69. Stem Cells 1994; 12: 456-465.
51. Nishimura T, Kitamura H, Iwakabe K et al. The interface between innate and acquired immunity: Glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int Immunol 2000; 12: 987-994.
52. Borrow P, Tishon A, Lee S et al. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J Exp Med 1996; 183: 2129-2142.
53. Toes REM, Schoenberger SP, van der Voort EIH, Offringa R, Melief CJM. CD40-CD40 Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity. Semin Immunol 1998; 10: 443-448.
54. Zhai Y, Shen XD, Gao F et al. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol 2002; 169: 1270-1276.
55. Rocha PN, Plumb TJ, Crowley SD, Coffman TM. Effector mechanisms in transplant rejection. Immunol Rev 2003; 196: 51-64.