Prolonged allograft survival in anti-CD4 antibody transgenic mice: Lack of residual helper T cells compared with other CD4-deficient mice

Transplantation

Volumn 70, Issue 1, 2000, Pages 168-174

  Han, Wen Ruo ^c   Zhan, Yifan ^c   Murray Segal, Lisa J ^c   Brady, Jamie L ^c   Lew, Andrew M ^b   Mottram, Patricia L ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHIMERIC ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OKT 4; OKT 8; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTER; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HELPER CELL; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; KNOCKOUT MOUSE; LYMPHOCYTE DEPLETION; LYMPHOCYTIC INFILTRATION; LYMPHOCYTOPENIA; MALE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLOGRAFT; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOGLOBULIN G; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; SKIN TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS;

EID: 0034661620     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Charlton B, Auchincloss H Jr, Fathman CG. Mechanisms of transplantation tolerance. Annu Rev Immunol 1994; 12: 707.
2. Cobbold SP, Adams E, Marshall SE, Davies JD, Waldmann H. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol Rev 1996; 149: 5.
3. Dialynas DP, Quan ZS, Wall KA, et al. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol 1983; 131: 2445.
4. Shizuru JA, Alters SE, Fathman CG. Anti-CD4 monoclonal antibodies in therapy: creation of nonclassical tolerance in the adult. Immunol Rev 1992; 129: 105.
5. Wood P, Roberts I, Yang C, Cossens I, Bell E. Prevention of chronic rejection by donor-specific blood transfusion in a new model of chronic cardiac allograft rejection. Transplantation 1996; 61: 1440.
6. Mottram P, Raisanen-Sokolowski A, Glysing-Jensen T, Stein-Oakley AN, Russell ME. Redefining peripheral tolerance in the BALB/c to CBA mouse cardiac allograft model: vascular and cytokine analysis after transient CD4 T cell depletion. Transplantation 1998; 66: 1510.
7. Wofsy D, Mayes D, Woodcock J, Seaman W. Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice. J Immunol 1985; 135: 1698.
8. Raisanen-Sokolowski A, Glysing-Jensen T, Mottram P, Russell M. Sustained anti-CD4/CD8 blocks inflammatory activation and intimal thickening in mouse heart allografts. Arterioscl Thromb Vasc Biol 1997; 17: 2115.
9. + T cells in major histocompatibility complex class II-deficient mice. Science 1991; 253: 1417.
10. Gusby M, Glimsher L. Immune responses in MHC class-II deficient mice. Annu Rev Immunol 1995; 13: 417.
11. Cardell S, Merkenschlager M, Bodmer H, et al. The immune system of mice lacking conventional MHC class II molecules. Adv Immunol 1994; 55: 423.
12. Takamoto M, Wang ZX, Watanabe N, Matsuzawa A, Nariuchi H, Sugane K. Eosinophilia, IgE production, and cytokine production by lung T cells in surface CD4-deficient mutant mice infected with Toxocara canis. Immunology 1998; 95: 97.
13. Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 1993; 261: 1448.
14. + cells are essential for allorejection. J Exp Med 1996; 184: 2013.
15. He G, Hart J, Kim O, et al. The role of CD8 and CD4 T cells in intestinal allograft rejection: a comparison of monoclonal antibody-treated and knockout mice. Transplantation 1999; 67: 131.
16. Boyle J, Silva A, Brady J, Lew A. DNA immunization: induction of higher avidity antibody and effect of route on T cell cytotoxicity. Proc Natl Acad Sci USA 1997; 94: 14626.
17. Killeen N, Sawada S, Littman D. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J 1993; 12: 1547.
18. Ledbetter J, Herzenberg LA. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev 1979; 47: 64.
19. Cobbold SP, Martin G, Waldmann H. The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies. Eur J Immunol 1990; 20: 2747.
20. Tomonari K. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex. Immunogenetics 1988; 28: 455.
21. Qin S, Cobbold S, Tighe H, Benjamin R, Waldmann H. CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur J Immunol 1987; 17: 1159.
22. Ridderstrad A, Nossal G, Tarlinton D. The xid mutation diminishes memory B cell generation but does not affect hypermutation and selection. J Immunol 1996; 157: 3357.
23. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice: the role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16: 343.
24. Mottram PL, Purcell LJ, Kalina SL. Microsurgical techniques for transplantation of vascularised organs in mice. In: Green MK, Mandel TE, eds. Experimental transplantation models in small animals. Melbourne, Australia: Gordon and Breach Science Publishers, 1995: 175.
25. Mottram PL, Smith JA, Mason A, Mirisklavos A, Dumble LJ, Clunie GJ. Electrocardiographic monitoring of cardiac transplants in mice. Cardiovasc Res 1988; 22: 315.
26. Billingham R, Medewar P. Technique of free skin grafting in mammals. J Exp Biol 1951; 28: 385.
27. Sander B, Hoiden I, Anderssen U, Moller E, Abrams JS. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. J Immunol Methods 1996; 166: 201.
28. Mottram PL, Han W-R, Purcell LJ, McKenzie IFC, Hancock WW. IL-4 and IL-10 but not IL-2 or IFN-γ cytokine expression in long-surviving mouse heart allografts after brief CD4 mAb therapy. Transplantation 1995; 59: 559.
29. Brown M, Engelman L, Frans J, Hill M, Jennich R, Toporek J. BMDP Statistical Software: 1983 printing with additions. Berkeley, CA: University of California Press, 1983.
30. + T cells. Transplantation 1992; 54: 483.
31. + T cells in major histocompatibility complex class II-deficient mice. J Exp Med 1995; 182: 993.
32. Han W, Murray-Segal L, Mottram P. Assessment of peripheral tolerance in anti-CD4 treated C57BL/6 mouse heart transplant recipients. Transpl Immunol 1999; 7: 37.
33. Mottram PL, Purcell LJ, Pietersz GA, McKenzie IF. Tolerance induction with anti-CD8 monoclonal antibodies in the mouse heart transplant model. Transplant Proc 1993; 25: 2935.
34. + T cell subsets [published erratum appears in Transplantation 1986 Sep;42(3):332]. Transplantation 1986; 41: 634.
35. Loveland B, Hogarth P, Ceredig R, McKenzie I. Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection. J Exp Med 1982; 153: 1044.
36. Pearson TC, Darby CR, Bushell AR, West LJ, Morris PJ, Wood KJ. The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model. Transplantation 1993; 55: 361.
37. Qin S, Cobbold SP, Pope H, et al. Infectious transplantation tolerance. Science 1993; 259: 974.
38. Hayry P, Defendi V. Mixed lymphocyte cultures produce effector cells: model in vitro for allograft rejection. Science 1970; 168: 133.
39. Marshall S, Cobbold S, Davies J, Martin G, Phillips J, Waldmann H. Tolerance and suppression in a primed immune system. Transplantation 1996; 62: 1614.
40. Hall BM. Cells mediating allograft rejection. Transplantation 1991; 51: 1141.
41. Stepkowski S, Duncan W. The role of TDTH and Tc populations in organ graft rejection. I. Functional analysis of graft-infiltrating cells. Transplantation 1986; 42: 406.
42. Dallman MJ, Wood KJ, Morris PJ. Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats. J Exp Med 1987; 165: 566.
43. Allan JS, Choo JK, Vesga L, et al. Cardiac allograft vasculopathy is abrogated by anti-CD8 monoclonal antibody therapy. Ann Thorac Surg 1997; 64: 1019.
44. Davies JD, Cobbold SP, Waldmann H. Strain variation in susceptibility to monoclonal antibody-induced transplantation tolerance. Transplantation 1997; 63: 1570.
45. Miyazaki T, Wolf P, Tourne S, et al. Mice lacking H2-M com plexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 1996; 84: 531.
46. + cytotoxic T cells in CD4-deficient mice. Eur J Immunol 1995; 25: 1109.