Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway

Journal of Immunology

Volumn 179, Issue 1, 2007, Pages 682-690

  Vepachedu, Ramarao ^a   Gorska, Magdalena M ^a   Singhania, Neil ^a   Cosgrove, Gregory P ^a   Brown, Kevin K ^a   Alam, Rafeul ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALPHA SMOOTH MUSCLE ACTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; PROTEIN UNC119; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; MYOFIBROBLAST; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VERTEBRATE;

EID: 34250795558     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.179.1.682     Document Type: Article

References (39)

1. Powell, D. W., R. C. Mifflin, J. D. Valentich, S. E. Crowe, J. I. Saada, and A. B. West. 1999. Myofibroblasts. I. Paracrine cells important in health and disease. Am. J. Physiol. 277: C1-C9.
2. Brewster, C. E., P. H. Howarth, R. Djukanovic, J. Wilson, S. T. Holgate, and W. R. Roche. 1990. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 3: 507-511.
3. Gizycki, M. J., E. Adelroth, A. V. Rogers, P. M. O'Byrne, and P. K. Jeffery. 1997. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am. J. Respir. Cell Mol. Biol. 16: 664-673.
4. Elias, J. A., Z. Zhu, G. Chupp, and R. J. Homer. 1999. Airway remodeling in asthma. J. Clin. Invest. 104: 1001-1006.
5. Varga, J., J. Rosenbloom, and S. A. Jimenez. 1987. Transforming growth factor β (TGF β) causes a persistent increase in steady-state amounts of type 1 and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem. J. 247: 597-604.
6. Batra, V., A. I. Musani, A. T. Hastie, S. Khurana, K. A. Carpenter, J. G. Zangrilli, and S. P. Peters. 2004. Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-β1, TGF-β2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on a-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts. Clin. Exp. Allergy 34: 437-444.
7. Sommer, M., U. Eismann, J. Gerth, and G. Stein. 2002. Interleukin 4 co-stimulates the PDGF-BB- and bFGF-mediated proliferation of mesangial cells and myofibroblasts. Nephron 92: 868-880; discussion 880-862.
8. Redington, A. E., J. Madden, A. J. Frew, R. Djukanovic, W. R. Roche, S. T. Holgate, and P. H. Howarth. 1997. Transforming growth factor-β1 in asthma: measurement in bronchoalveolar lavage fluid. Am. J. Respir. Crit. Care Med. 156: 642-647.
9. Thomas, S. M., and J. S. Brugge. 1997. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 13: 513-609.
10. Twamley-Stein, G. M., R. Pepperkok, W. Ansorge, and S. A. Courtneidge. 1993. The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells. Proc. Natl Acad. Sci. USA 90: 7696-7700.
11. 28 in the N-terminus of Fyn affects Fyn activation. Biochem. Biophys. Res. Commun. 241: 355-362.
12. Thannickal, V. J., D. Y. Lee, E. S. White, Z. Cui, J. M. Larios, R. Chacon, J. C. Horowitz, R. M. Day, and P. E. Thomas. 2003. Myofibroblast differentiation by transforming growth factor-β1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J. Biol. Chem. 278: 12384-12389.
13. Sicheri, F., and J. Kuriyan. 1997. Structures of Src-family tyrosine kinases. Curr. Opin. Struct. Biol. 7: 777-785.
14. Cen, O., M. M. Gorska, S. J. Stafford, S. Sur, and R. Alam. 2003. Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. J. Biol. Chem. 278: 8837-8845.
15. Gorska, M. M., S. J. Stafford, O. Cen, S. Sur, and R. Alam. 2004. Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J. Exp. Med. 199: 369-379.
16. Frankel, S. K., G. P. Cosgrove, S. I. Cha, C. D. Cool, M. W. Wynes, B. L. Edelman, K. K. Brown, and D. W. Riches. 2006. TNF-α sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am. J. Respir. Cell Mol. Biol. 34: 293-304.
17. Maduro, M., and D. Pilgrim. 1995. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141: 977-988.
18. Maduro, M. F., M. Gordon, R. Jacobs, and D. B. Pilgrim. 2000. The UNC-119 family of neural proteins is functionally conserved between humans, Drosophila and C. elegans. J. Neurogenet. 13: 191-212.
19. Knobel, K. M., W. S. Davis, E. M. Jorgensen, and M. J. Bastiani. 2001. UNC-119 suppresses axon branching in C. elegans. Development 128: 4079-4092.
20. Manning, A. G., B. D. Crawford, A. J. Waskiewicz, and D. B. Pilgrim. 2004. unc-119 homolog required for normal development of the zebraflsh nervous system. Genesis 40: 223-230.
21. Higashide, T., and G. Inana. 1999. Characterization of the gene for HRG4 (UNCI 19), a novel photoreceptor synaptic protein homologous to unc-119. Genomics 57: 446-450.
22. Kobayashi, A., T. Higashide, D. Hamasaki, S. Kubota, H. Sakuma, W. An, T. Fujimaki, M. J. McLaren, R. G. Weleber, and G. Inana. 2000. HRG4 (UNC119) mutation found in cone-rod dystrophy causes retinal degeneration in a transgenic model. Invest. Ophthalmol. Vis. Sci. 41: 3268-3277.
23. Zhan, X., C. Plourde, X. Hu, R. Friesel, and T. Maciag. 1994. Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin. J. Biol. Chem. 269: 20221-20224.
24. Kypta, R. M., Y. Goldberg, E. T. Ulug, and S. A. Courtneidge. 1990. Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62: 481-492.
25. Abram, C. L., and S. A. Courtneidge. 2000. Src family tyrosine kinases and growth factor signaling. Exp. Cell Res. 254: 1-13.
26. Kilkenny, D. M., J. V. Rocheleau, J. Price, M. B. Reich, and G. G. Miller. 2003. c-Src regulation of fibroblast growth factor-induced proliferation in murine embryonic fibroblasts. J. Biol. Chem. 278: 17448-17454.
27. Sperber, B. R., E. A. Boyle-Walsh, M. J. Engleka, P. Gadue, A. C. Peterson, P. L. Stein, S. S. Scherer, and F. A. McMorris. 2001. A unique role for Fyn in CNS myelination. J. Neurosci. 21: 2039-2047.
28. Phan, S. H. 2002. The myofibroblast in pulmonary fibrosis. Chest 122: 286S-289S.
29. Pardo, A., and M. Selman. 2002. Idiopathic pulmonary fibrosis: new insights in its pathogenesis. Int. J. Biochem. Cell Biol. 34: 1534-1538.
30. Redington, A. E. 2000. Fibrosis and airway remodelling. Clin. Exp. Allergy 30(Suppl. 1): 42-45.
31. Gabbiani, G. 2003. The myofibroblast in wound healing and fibrocontractive diseases. J. Pathol. 200: 500-503.
32. Ina, K., H. Kitamura, S. Tatsukawa, T. Takayama, Y. Fujikura, and T. Shimada. 2002. Transformation of interstitial fibroblasts and tubulointerstitial fibrosis in diabetic nephropathy. Med. Electron Microsc. 35: 87-95.
33. Kissin, E. Y., and J. H. Korn. 2003. Fibrosis in scleroderma. Rheum. Dis. Clin. North Am. 29: 351-369.
34. Hashimoto, S., Y. Gon, I. Takeshita, K. Matsumoto, S. Maruoka, and T. Horie. 2001. Transforming growth factor-β1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. Am. Respir. Crit. Care Med. 163: 152-157.
35. Javelaud, D., and A. Mauviel. 2005. Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-β: implications for carcinogenesis. Oncogene 24: 5742-5750.
36. Hu, Y., J. Peng, D. Feng, L. Chu, X. Li, Z. Jin, Z. Lin, and Q. Zeng. 2006. Role of extracellular signal-regulated kinase, p38 kinase, and activator protein-1 in transforming growth factor-β1-induced α smooth muscle actin expression in human fetal lung fibroblasts in vitro. Lung 184: 33-42.
37. Furukawa, F., K. Matsuzaki, S. Mori, Y. Tahashi, K. Yoshida, Y. Sugano, H. Yamagata, M. Matsushita, T. Seki, Y. Inagaki, et al. 2003. p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Hepatology 38: 879-889.
38. Gallucci, R. M., E. G. Lee, and J. J. Tomasek. 2006. IL-6 modulates α-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J. Invest. Dermatol. 126: 561-568.
39. Aoki, H., H. Ohnishi, K. Hama, S. Shinozaki, H. Kita, H. Yamamoto, H. Osawa, K. Sato, K. Tamada, and K. Sugano. 2006. Existence of autocrine loop between interleukin-6 and transforming growth factor-β1 in activated rat pancreatic stellate cells. J. Cell. Biochem. 99: 221-228.