The metabolism of L-DOPA and L-threo-3,4-dihydroxyphenylserine and their effects on monoamines in the human brain: Analysis of the intraventricular fluid from parkinsonian patients

Journal of the Neurological Sciences

Volumn 139, Issue 1, 1996, Pages 141-148

  Maruyama, Wakako ^a   Naoi, Makoto ^b   Narabayashi, Hirotaro ^c  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^c Neurological Clinic   (Japan)

Author keywords

Catechol O methyltransferase; Intraventricular fluid; L DOPA; L Threo dihydroxyphenylserine; Monoamine; Parkinson's disease

Indexed keywords

CARBIDOPA PLUS LEVODOPA; DOPAMINE; LEVODOPA; NORADRENALIN;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MONOAMINE METABOLISM; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0030200671     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(96)00049-4     Document Type: Article

References (15)

1. Bonnet, A.M., Loria, Y., Saint-Hilaire, M.H., Lhermitte, F. and Agid, Y. (1987) Does long-term aggravation of Parkinson's disease result from nondopaminergic lesions? Neurology, 37: 1539-1542.
2. Garelis, E., Young, S.N., Lal, S. and Sourkes, L. (1974) Monoamine metabolism in lumbar CSF: the question of their origin in relation to clinical studies. Brain Res., 79: 1-8.
3. Gordonsmith, R.H., Raxworthy, M.J. and Gulliver, P.A. (1982) Substrate stereospecificity and selectivity of catechol-O-methyltransferase for DOPA. DOPA derivatives and α-substituted catecholamines. Biochem. Pharmacol., 31: 433-437.
4. Kopin, I.J., Gordon, E.K., Jimerson, D.C. and Polinsky, R.J. (1983) Relation between plasma and cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol. Science, 219: 73-75.
5. Maruyama, W., Naoi, M., Takahashi, A., Watanabe, H., Konagaya, Y., Mokuno, K., Hasegawa, S. and Nakahara, D. (1992) The mechanism of perturbation in monoamine metabolism by L-DOPA therapy: in vivo and in vitro studies. J. Neural Transm. [GenSect], 90: 183-197.
6. Maruyama, W., Nakahara, D. and Naoi, M. (1994a) A new metabolic pathway of L-threo-3,4-dihydroxyphenylserine, a precursor amino acid of norepinephrine, in the brain. Studies by in vivo microdialysis. J. Neural Transm. [P-D Sect], 7: 21-33.
7. Maruyama, W., Narabayashi, H. and Naoi, M. (1994b) Study on the metabolism of droxidopa in humans. Rinsho Shinkeigaku, 34: 991-995 (in Japanese).
8. Nagatsu, T., Wakui, Y., Kato, T., Fujita, K., Kondo, T., Yokochi, F. and Narabayashi, H. (1982) Dopamine beta-hydroxylase activity in cerebrospinal fluid of parkinsonian patients. Biomed. Res., 3: 95-98.
9. Naoi, M., Takahashi, T., Kuno, N. and Nagatsu, T. (1987) L-Threo-3,4-dihydroxyphenylserine (DOPS) aldolase: a new enzyme cleaving DOPS into protocatechualdehyde and glycine. Biochem. Biophys. Res Commun. 13, 482-488.
10. Naoi, M., Maruyama, W., Acworth, I.N., Nakahara, D. and Parvez, H. (1993) Multi-electrode detection system for determination of neurotransmitters. In: Parvez S.H., Naoi M., Nagatsu T., Parvez S., (Eds.), Methods in Neurotransmitter and Neuropeptide Research, Part I, Elsevier, Amsterdam, pp. 1-39
11. Narabayashi, H., Kondo, T., Hayaishi, A., Suzuki, T. and Nagatsu, T. (1981) L-Threo-3,4-dihydroxyphenylserine treatment for akinesia and freezing of parkinsonism. Proc. Japan. Acad., 57: 351-354.
12. Nic a'Bhaird, N., Goldberg, R. and Tipton, K.F. (1990) Catechol-O-methyltransferase and its role in catecholamine metabolism. In: Streifler M.B., Korczyn A.D., Melamed E. and Youdim M.B.H. (Eds.), Advances in Neurology, Vol. 53 Raven press, New York, pp. 489-495.
13. Papeschi, R., Molina-Negro, P., Sourkes, T.L. and Erba, G. (1972) The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Neurology, 22: 1151-1159.
14. Tabaddor, K., Wolfson, L.I. and Sharpless, N.S. (1978) Ventricular fluid homovanillic acid concentrations in patients with movement disorders. Neurology, 28: 1249-1253.
15. Wester, P., Bergstroem, U., Eriksson, A., Gezelius, C., Hardy, J. and Winblad, B. (1990) Ventricular cerebrospinal fluid monoamine transmitter and metabolite concentrations reflect human brain neurochemistry in autopsy cases. J. Neurochem., 54: 1148-1156.