Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors

Parasitology Research

Volumn 95, Issue 1, 2005, Pages 73-76

  Steverding, Dietmar ^a   Spackman, Robert W ^a   Royle, Howard J ^a   Glenn, Robert J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 NITROPHENYLACETYLLEUCYLLEUCYLLEUCYLMETHYLVINYLSULFONE; 4 HYDROXY 5 IODO 3 NITROPHENYLACETYLLEUCYLLEUCYLLEUCYLMETHYLVINYLSULFONE; ANTITRYPANOSOMAL AGENT; N BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCYLMETHYLVINYLSULFONE; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ANIMALS; DRUG EVALUATION, PRECLINICAL; OLIGOPEPTIDES; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; SULFONES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPSIN INHIBITORS;

KOBUS; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 12444256377     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-004-1253-y     Document Type: Article

References (23)

1. Adams J (2003) Potential for proteasome inhibition in the treatment of cancer. Drug Discov Today 8:307-315
2. Adams J (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5:417-421
3. Adams J, Palombella VJ, Sausville EA, Johnson J, Destree A, Lazarus DD, Maas J, Pien CS, Prakash S, Elliott PJ (1999) Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 59:2615-2622
4. Baltz T, Baltz D, Giroud C, Crockett J (1985) Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J 4:1273-1277
5. Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H (1997) Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HsIV by a new class of inhibitors. Proc Natl Acad Sci U S A 94:6629-6634
6. Bogyo M, Shin S, McMaster JS, Ploegh HL (1998) Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes. Chem Biol 5:307-320
7. Burchmore RJ, Ogbunude PO, Enanga B, Barrett MP (2002) Chemotherapy of human African trypanosomaisis. Curr Pharm Des 8:256-267
8. Coux O, Tanaka K, Goldberg AL (1996) Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem 65:801-847
9. Glenn RJ, Pemberton AJ, Royle HJ, Spackman RW, Smith E, Rivett AJ, Steverding D (2004) Trypanocidal effect of α′,/β′- epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. Int J Antimicrob Agents 24:286-289
10. Hirumi H, Hirumi K, Doyle JJ, Cross GAM (1980) In vitro cloning of animal-infective bloodstream forms of Trypanosoma brucei. Parasitology 80:371-382
11. Hua S-B, To W-Y, Nguyen TT, Wong M-L, Wang CC (1996) Purification and characterization of proteasomes from Trypanosoma brucei. Mol Biochem Parasitol 78:33-46
12. 50 in studies of drug resistance of malaria parasites. Acta Trop 55:257-261
13. Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS (2001) Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits. Chem Biol 8:913-929
14. Kisselev AF, Goldberg AL (2001) Proteasome inhibitors: from research tools to drug candidates. Chem Biol 8:739-758
15. Matovu E, Seebeck T, Enyaru JCK, Kaminsky R (2001) Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle. Microbes Infect 3:763-770
16. Merschjohann K, Sporer F, Steverding D, Wink M (2001) In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. Planta Med 67:623-627
17. Morrison JF, Walsh CT (1988) The behavior and significance of slow-binding enzyme inhibitors. Adv Enzymol Relat Areas Mol Biol 61:201-301
18. Nazif T, Bogyo M (2001) Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors. Proc Natl Acad Sci U S A 98:2967-2972
19. Nkemgu-Njinkeng J, Rosenkranz V, Wink M, Steverding D (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrob Agents Chemother 46:2038-2040
20. Palmer JT, Rasnick D, Klaus JL, Brömme D (1995) Vinyl sulfones as mechanism-based cysteine protease inhibitors. J Med Chem 38:3193-196
21. Scory S, Steverding D (1997) Differential toxicity of ricin and diphtheria toxin for bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol 90:289-295
22. Wang CC, Bozdech Z, Liu CL, Shipway A, Backes BJ, Harris JL, Bogyo M (2002) Biochemical analysis of the 20S proteasome of Trypanosoma brucei. J Biol Chem 278:15800-15808
23. World Health Organisation (2001) African trypanosomiasis or sleeping sickness. World Health Organ Fact Sheet 259:http://www.who.int/mediacentre/ factsheets/fs259/en