Potent inhibition of scrapie prion replication in cultured cells by bis-acridines

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 6, 2003, Pages 3416-3421

  May, Barnaby C H ^a,b   Fafarman, Aaron T ^a   Hong, Septima B ^a,b   Rogers, Michael ^c   Deady, Leslie W ^c   Prusiner, Stanley B ^a,b   Cohen, Fred E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LA TROBE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

(6 CHLORO 2 METHOXYACRIDIN 9 YL)[3 [4 [3 (6 CHLORO 2 METHOXYACRIDIN 9 YLAMINO)PROPYL]PIPERAZIN 1 YL]PROPYL]AMINE; [1 [[4 (6 CHLORO 2 METHOXYACRIDIN 9 YLAMINO)BUTYL][3 (6 CHLORO 2 METHOXYACRIDIN 9 YLAMINO)PROPYL]CARBAMOYL]ETHYL]CARBAMIC ACID TERT BUTYL ESTER; ACRIDINE DERIVATIVE; BIS(6 CHLORO 2 METHOXYACRIDIN 9 YL) DERIVATIVE; BIS(7 CHLORO 2 METHOXYBENZO[B][1,5]NAPHTHYRIDIN 10 YL) DERIVATIVE; MEPACRINE; N,N' BIS(6 CHLORO 2 METHOXYACRIDIN 9 YL) 1,8 DIAMINO 3,6 DIOXAOCTANE; PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; MOUSE; NEUROBLASTOMA; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN FOLDING; SCRAPIE; STRUCTURE ACTIVITY RELATION;

ACRIDINES; ANIMALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; PRION DISEASES; PRPSC PROTEINS; QUINACRINE;

ANIMALIA; SCRAPIE PRION;

EID: 0037452925     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2627988100     Document Type: Article

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