메뉴 건너뛰기




Volumn 47, Issue 1, 2003, Pages 174-180

In vitro activities of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes against Leishmania infantum

Author keywords

[No Author keywords available]

Indexed keywords

9 AMINO 2 METHOXYACRIDINE DERIVATIVE; 9 CHLORO 2 METHOXYACRIDINE DERIVATIVE; ANTILEISHMANIAL AGENT; UNCLASSIFIED DRUG;

EID: 12244272194     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.1.174-180.2003     Document Type: Article
Times cited : (51)

References (33)
  • 1
    • 0036464507 scopus 로고    scopus 로고
    • Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: Implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons
    • Adams, A., J. M. Guss, W. A. Denny, and L. P. Wakelin. 2002. Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons. Nucleic Acids Res. 30:719-725.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 719-725
    • Adams, A.1    Guss, J.M.2    Denny, W.A.3    Wakelin, L.P.4
  • 3
    • 0035959980 scopus 로고    scopus 로고
    • Synthesis, antitumor cytotoxicity and DNA-binding of novel N-5,2-di(ω-aminoalkyl)-2,6-dihydropyrazolo[3,4, 5-k]acridine-5-carbomamides
    • Antonini, I., P. Polucci, A. Magnano, and M. Sante. 2001. Synthesis, antitumor cytotoxicity and DNA-binding of novel N-5,2-di(ω-aminoalkyl)-2,6-dihydropyrazolo[3,4, 5-k]acridine-5-carbomamides. J. Med. Chem. 56:3329-3333.
    • (2001) J. Med. Chem. , vol.56 , pp. 3329-3333
    • Antonini, I.1    Polucci, P.2    Magnano, A.3    Sante, M.4
  • 4
    • 0031239574 scopus 로고    scopus 로고
    • Leishmania infantum promastigotes: Flow cytometry as a possible tool for assessing the effects of drugs on cellular functions
    • Azas, N., C. Di Giorgio, F. Delmas, M. Gasquet, and P. Timon-David. 1997. Leishmania infantum promastigotes: flow cytometry as a possible tool for assessing the effects of drugs on cellular functions. Exp. Parasitol. 87:1-7.
    • (1997) Exp. Parasitol. , vol.87 , pp. 1-7
    • Azas, N.1    Di Giorgio, C.2    Delmas, F.3    Gasquet, M.4    Timon-David, P.5
  • 5
    • 0018187043 scopus 로고
    • Diacridines, bifunctional intercalators. Chemistry and antitumor activity
    • Chen, T. K., R. Fico, and E. S. Canellakis. 1978. Diacridines, bifunctional intercalators. Chemistry and antitumor activity. J. Med. Chem. 21:868-874.
    • (1978) J. Med. Chem. , vol.21 , pp. 868-874
    • Chen, T.K.1    Fico, R.2    Canellakis, E.S.3
  • 7
    • 0036240055 scopus 로고    scopus 로고
    • Chemotherapy of leishmaniasis
    • Croft, S. L., and Y. Yardley V. 2002. Chemotherapy of leishmaniasis. Curr. Pharmacol. 8:319-342.
    • (2002) Curr. Pharmacol. , vol.8 , pp. 319-342
    • Croft, S.L.1    Yardley, V.Y.2
  • 8
    • 0034781209 scopus 로고    scopus 로고
    • Interest of acridine derivatives in the anticancer chemotherapy
    • Demeunynck, M., F. Charmantray, and A. Martelli. 2001. Interest of acridine derivatives in the anticancer chemotherapy. Curr. Pharmacol. Des. 7:1703-1724.
    • (2001) Curr. Pharmacol. Des. , vol.7 , pp. 1703-1724
    • Demeunynck, M.1    Charmantray, F.2    Martelli, A.3
  • 9
    • 0022376055 scopus 로고
    • Potential antitumor agents. Synthesis and antitumor activity of new classes of diacridines. The importance of the linker chain rigidity for DNA binding kinetics and biological activity
    • Denny, W. A., G. J. Atwell, B. C. Baguley, and L. P. Wakelin. 1985. Potential antitumor agents. Synthesis and antitumor activity of new classes of diacridines. The importance of the linker chain rigidity for DNA binding kinetics and biological activity. J. Med. Chem. 28:1568-1574.
    • (1985) J. Med. Chem. , vol.28 , pp. 1568-1574
    • Denny, W.A.1    Atwell, G.J.2    Baguley, B.C.3    Wakelin, L.P.4
  • 10
    • 0034047105 scopus 로고    scopus 로고
    • Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs
    • Finlay, G. J., and B. C. Baguley. 2000. Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs. Cancer Chemother. Pharmacol. 45:417-422.
    • (2000) Cancer Chemother. Pharmacol. , vol.45 , pp. 417-422
    • Finlay, G.J.1    Baguley, B.C.2
  • 11
    • 0035175731 scopus 로고    scopus 로고
    • Development status of miltefosine as first oral drug in visceral and cutaneous leishmaniasis
    • Fischer, C., A. Voss, and J. Engel. 2001. Development status of miltefosine as first oral drug in visceral and cutaneous leishmaniasis. Med. Microbiol. Immunol. (Berlin) 190:85-87.
    • (2001) Med. Microbiol. Immunol. (Berlin) , vol.190 , pp. 85-87
    • Fischer, C.1    Voss, A.2    Engel, J.3
  • 14
    • 0034644136 scopus 로고    scopus 로고
    • Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino6-chloro-2-methoxyacridines): Influence of the linker
    • Girault, S., P. Grellier, A. Berecibar, L. Maes, E. Mouray, P. Lemiere, M. A. Debreu, E. Davioud-Charvet, and C. Sergheraert. 2000. Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino6-chloro-2-methoxyacridines): influence of the linker. J. Med. Chem. 43: 2646-2654.
    • (2000) J. Med. Chem. , vol.43 , pp. 2646-2654
    • Girault, S.1    Grellier, P.2    Berecibar, A.3    Maes, L.4    Mouray, E.5    Lemiere, P.6    Debreu, M.A.7    Davioud-Charvet, E.8    Sergheraert, C.9
  • 15
    • 0021923858 scopus 로고
    • Nile red: A selective fluorescent stain for intracellular lipid droplets
    • Greenspan, P., E. P. Mayer, and S. D. Fowler. 1985. Nile red: a selective fluorescent stain for intracellular lipid droplets. J. Cell Biol. 100:965-973.
    • (1985) J. Cell Biol. , vol.100 , pp. 965-973
    • Greenspan, P.1    Mayer, E.P.2    Fowler, S.D.3
  • 16
    • 0024853396 scopus 로고
    • A review of the geographic distribution and epidemiology of leishmaniasis in the New World
    • Grimaldi, R., G. R. Tesh, and C. McMahon-Pratt. 1989. A review of the geographic distribution and epidemiology of leishmaniasis in the New World. Am. J. Trop. Med. Hyg. 41:687.
    • (1989) Am. J. Trop. Med. Hyg. , vol.14 , pp. 687
    • Grimaldi, R.1    Tesh, G.R.2    McMahon-Pratt, C.3
  • 17
    • 0033517487 scopus 로고    scopus 로고
    • Leishmaniasis
    • Herwalt, B. L. 1999. Leishmaniasis. Lancet 354:1191-1199.
    • (1999) Lancet , vol.354 , pp. 1191-1199
    • Herwalt, B.L.1
  • 18
    • 0033737778 scopus 로고    scopus 로고
    • PASS: Prediction of activity spectra for biologically active substances
    • Lagunin, A., A. Stepanchikova, D. Filimonov, and V. Poroikov. 2000. PASS: prediction of activity spectra for biologically active substances. Bioinformatics 16:747-748.
    • (2000) Bioinformatics , vol.16 , pp. 747-748
    • Lagunin, A.1    Stepanchikova, A.2    Filimonov, D.3    Poroikov, V.4
  • 21
    • 0033652949 scopus 로고    scopus 로고
    • Quantitative analysis of structure-activity relationship in the acridine series. 1. Antiparasitic 9-thioaryl-acridine derivatives
    • Mrozek, A., J. Karolak-Wojciechowska, N. Bsiri, and J. Barbe. 2000. Quantitative analysis of structure-activity relationship in the acridine series. 1. Antiparasitic 9-thioaryl-acridine derivatives. Acta Pol. Pharm. 57:345-351.
    • (2000) Acta Pol. Pharm. , vol.57 , pp. 345-351
    • Mrozek, A.1    Karolak-Wojciechowska, J.2    Bsiri, N.3    Barbe, J.4
  • 22
    • 0033658753 scopus 로고    scopus 로고
    • Treatment of visceral leishmaniasis (kala-azar): A decade of progress and future approaches
    • Murray, H. W. 2000. Treatment of visceral leishmaniasis (kala-azar): a decade of progress and future approaches. Int. J. Infect. Dis. 4:158-177.
    • (2000) Int. J. Infect. Dis. , vol.4 , pp. 158-177
    • Murray, H.W.1
  • 23
    • 0025275478 scopus 로고
    • Interactions between the human monocytic leukaemia THP1 cell line and Old and New World species of Leishmania
    • Ogunkolade, B. W., I. Colomb-Valet, L. Monjour, A. Rhodes-Feuillette, J. P. Abita, and D. Frommel. 1990. Interactions between the human monocytic leukaemia THP1 cell line and Old and New World species of Leishmania. Acta Trop. 47:171-176.
    • (1990) Acta Trop. , vol.47 , pp. 171-176
    • Ogunkolade, B.W.1    Colomb-Valet, I.2    Monjour, L.3    Rhodes-Feuillette, A.4    Abita, J.P.5    Frommel, D.6
  • 24
    • 0034320172 scopus 로고    scopus 로고
    • Robustness of biological activity spectra predicting by computer program pass for non-congeneric sets of chemical compounds
    • Poroikov, V. V., D. Filimonov, Y. Borodina, A. Lagunin, and A. Kos. 2000. Robustness of biological activity spectra predicting by computer program pass for non-congeneric sets of chemical compounds. J. Chem. Inform. Comput. Sci. 40:1349-1355.
    • (2000) J. Chem. Inform. Comput. Sci. , vol.40 , pp. 1349-1355
    • Poroikov, V.V.1    Filimonov, D.2    Borodina, Y.3    Lagunin, A.4    Kos, A.5
  • 25
    • 0033800421 scopus 로고    scopus 로고
    • Microbial analysis at the single-cell level: Tasks and techniques
    • Shapiro, H. M. 2000. Microbial analysis at the single-cell level: tasks and techniques. J. Microbiol. Methods 42:3-16.
    • (2000) J. Microbiol. Methods , vol.42 , pp. 3-16
    • Shapiro, H.M.1
  • 26
    • 0000428427 scopus 로고    scopus 로고
    • Synthesis of new bisand tetra-acridines
    • Sourdon, V., S. Mazoyer, V. Pique, and J. P. Galy. 2001. Synthesis of new bisand tetra-acridines. Molecules 6:673-682.
    • (2001) Molecules , vol.6 , pp. 673-682
    • Sourdon, V.1    Mazoyer, S.2    Pique, V.3    Galy, J.P.4
  • 27
    • 0036131936 scopus 로고    scopus 로고
    • Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-targeted anticancer drugs
    • Spicer, J. A., S. A. Gamage, G. J. Finlay, and W. A. Denny. 2002. Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-targeted anticancer drugs. Bioorg. Med. Chem. 10:19-29.
    • (2002) Bioorg. Med. Chem. , vol.10 , pp. 19-29
    • Spicer, J.A.1    Gamage, S.A.2    Finlay, G.J.3    Denny, W.A.4
  • 28
    • 0034780949 scopus 로고    scopus 로고
    • Drug resistance in Indian visceral leishmaniasis
    • Sundar, S. 2001. Drug resistance in Indian visceral leishmaniasis. Trop. Med. Int. Health 6:849-854.
    • (2001) Trop. Med. Int. Health. , vol.6 , pp. 849-854
    • Sundar, S.1
  • 29
    • 0035470269 scopus 로고    scopus 로고
    • Prediction of n-octanol/water partition coefficients from PHYSPROP database using artificial neural networks and E-state indices
    • Tekto, I. V., Y. Tanchuk, and A. Villa. 2001. Prediction of n-octanol/water partition coefficients from PHYSPROP database using artificial neural networks and E-state indices. J. Chem. Infect. Comput. Sci. 41:1407-1421.
    • (2001) J. Chem. Infect. Comput. Sci. , vol.41 , pp. 1407-1421
    • Tekto, I.V.1    Tanchuk, Y.2    Villa, A.3
  • 33
    • 4244165673 scopus 로고    scopus 로고
    • World Health Organization, Geneva, Switzerland. [Online.]
    • World Health Organization. 2002. Programme for the surveillance and control of leishmaniasis. World Health Organization, Geneva, Switzerland. [Online.] http://www.who.int/emc/diseases/leish/leishmaniasis.pdf.
    • (2002) Programme for the Surveillance and Control of Leishmaniasis


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.