Stem cell therapies for perinatal brain injuries

Seminars in Fetal and Neonatal Medicine

Volumn 12, Issue 4, 2007, Pages 259-272

  Vawda, Reaz ^a   Woodbury, Jennifer ^a   Covey, Matthew ^a   Levison, Steven W ^a   Mehmet, Huseyin ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Children; Head injury; Hypoxia; Ischaemia; Regenerative medicine; Stem cells

Indexed keywords

ADRENOLEUKODYSTROPHY; ARTICLE; BRAIN DISEASE; BRAIN INJURY; CELL DAMAGE; EMBRYONIC STEM CELL; GAUCHER DISEASE; HUMAN; LYSOSOME STORAGE DISEASE; MESENCHYMAL STEM CELL; METABOLIC DISORDER; METABOLIC ENCEPHALOPATHY; NEURAL STEM CELL; NEWBORN CARE; NONHUMAN; STEM CELL TRANSPLANTATION; TRAUMATIC BRAIN INJURY; WHITE MATTER; ZELLWEGER SYNDROME;

ADULT STEM CELLS; BRAIN INJURIES; CLINICAL TRIALS; EMBRYONIC STEM CELLS; FETAL STEM CELLS; HUMANS; HYPOXIA, BRAIN; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; METABOLIC DISEASES; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

EID: 34250023762     PISSN: 1744165X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.siny.2007.02.003     Document Type: Article

References (167)

1. Vannucci R.C., and Vannucci S.J. Perinatal hypoxic-ischemic brain damage: evolution of an animal model. Developmental Neuroscience 27 2-4 (2005) 81-86
2. Hill A. Current concepts of hypoxic-ischemic cerebral injury in the term newborn. Pediatric Neurology 7 5 (1991) 317-325
3. Espinoza M.I., and Parer J.T. Mechanisms of asphyxial brain damage, and possible pharmacologic interventions, in the fetus. American Journal Of Obstetrics & Gynecology 164 6 Pt 1 (1991) 1582-1589
4. Raichle M.E. The pathophysiology of brain ischemia. Annals of Neurology 13 1 (1983) 2-10
5. Hagberg H., Thornberg E., Blennow M., et al. Excitatory amino acids in the cerebrospinal fluid of asphyxiated infants: relationship to hypoxic-ischemic encephalopathy. Acta Paediatrica 82 11 (1993) 925-929
6. Puka-Sundvall M., Gajkowska B., Cholewinski M., Blomgren K., Lazarewicz J.W., and Hagberg H. Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats. Developmental Brain Research 123 (2000) 31-41
7. Puka-Sundvall M., Sandberg M., and Hagberg H. Brain injury after hypoxia-ischemia in newborn rats: relationship to extracellular levels of excitatory amino acids and cysteine. Brain Research 750 (1997) 325-328
8. Blomgren K., Zhu C., Wang X., et al. Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?. Journal of Biological Chemistry 276 13 (2001) 10191-10198
9. Gill R., Soriano M., Blomgren K., et al. Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain. Journal of Cerebral Blood Flow and Metabolism 22 4 (2002) 420-430
10. Wang X., Karlsson J.O., Zhu C., Bahr B.A., Hagberg H., and Blomgren K. Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia. Biology of The Neonate 79 3-4 (2001) 172-179
11. Zhu C., Wang X., Hagberg H., and Blomgren K. Correlation between caspase-3 activation and three different markers of DNA damage in neonatal cerebral hypoxia-ischemia. Journal of Neurochemistry 75 2 (2000) 819-829
12. Romanko M.J., Levison S.W., and Rothstein R.P. Neural stem cells in the subventricular zone are resilient to hypoxia/ischemia whereas progenitors are vulnerable. Journal of Cerebral Blood Flow and Metabolism 24 7 (2004) 814-825
13. Hu B.R., Liu C.L., Ouyang Y., Blomgren K., and Siesjo B.K. Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation. Journal of Cerebral Blood Flow and Metabolism 20 9 (2000) 1294-1300
14. Northington F.J., Ferriero D.M., Flock D.L., and Martin L.J. Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. Journal of Neuroscience 21 6 (2001) 1931-1938
15. Northington F.J., Ferriero D.M., and Martin L.J. Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death. Developmental Neuroscience 23 3 (2001) 186-191
16. Ness J.K., and Wood T.L. Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosis. Molecular and Cellular Neuroscience 20 3 (2002) 476-488
17. Vannucci R.C. Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. Pediatric Research 27 4 Pt 1 (1990) 317-326
18. Hammerman C., and Kaplan M. Ischemia and reperfusion injury. The ultimate pathophysiologic paradox. Clinics in Perinatology 25 3 (1998) 757-777
19. Foster-Barber A., Dickens B., and Ferriero D.M. Human perinatal asphyxia: correlation of neonatal cytokines with MRI and outcome. Developmental Neuroscience 23 3 (2001) 213-218
20. Oygur N., Sonmez O., Saka O., and Yegin O. Predictive value of plasma and cerebrospinal fluid tumour necrosis factor-alpha and interleukin-1 beta concentrations on outcome of full term infants with hypoxic-ischaemic encephalopathy. Archives of Disease in Childhood Fetal and Neonatal Edition 79 3 (1998) F190-F193
21. Counsell S.J., Rutherford M.A., Cowan F.M., and Edwards A.D. Magnetic resonance imaging of preterm brain injury. Archives of Disease in Childhood Fetal and Neonatal Edition 88 4 (2003) F269-F274
22. Maalouf E.F., Duggan P.J., and Rutherford M.A. Magnetic resonance imaging of the brain in a cohort of extremely preterm infants. Journal of Pediatrics 135 3 (1999) 351-357
23. Inder T., Huppi P.S., and Zientara G.P. Early detection of periventricular leukomalacia by diffusion-weighted magnetic resonance imaging techniques. Journal of Pediatrics 134 5 (1999) 631-634
24. Inder T.E., Huppi P.S., and Warfield S. Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term. Annals of Neurology 46 5 (1999) 755-760
25. Peterson B.S., Vohr B., and Staib L.H. Regional brain volume abnormalities and long-term cognitive outcome in preterm infants. Journal of the American Medical Association 284 15 (2000) 1939-1947
26. Peterson B.S., Anderson A.W., and Ehrenkranz R. Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants. Pediatrics 111 5 Pt 1 (2003) 939-948
27. Mcquillen P.S., Sheldon R.A., Shatz C.J., and Ferriero D.M. Selective vulnerability of subplate neurons after early neonatal hypoxia-ischemia. Journal of Neuroscience 23 8 (2003) 3308-3315
28. Sizonenko S.V., Sirimanne E., Mayall Y., Gluckman P.D., Inder T., and Williams C. Selective cortical alteration after hypoxic-ischemic injury in the very immature rat brain. Pediatric Research 54 2 (2003) 263-269
29. Sheldon R.A., Chuai J., and Ferriero D.M. A rat model for hypoxic-ischemic brain damage in very premature infants. Biology of the Neonate 69 5 (1996) 327-341
30. Curristin S.M., Cao A., and Stewart W.B. Disrupted synaptic development in the hypoxic newborn brain. Proceedings of the National Academy of Science of the United States of America 99 24 (2002) 15729-15734
31. Rothstein R.P., and Levison S.W. Gray matter oligodendrocyte progenitors and neurons die caspase-3 mediated deaths subsequent to mild perinatal hypoxic/ischemic insults. Developmental Neuroscience 27 2-4 (2005) 149-159
32. Greisen G. Cerebral blood flow in preterm infants during the first week of life. Acta Paediatrica Scandinavica 75 1 (1986) 43-51
33. Lou H.C., Han B.H., Luo N.L., et al. Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia. Acta Paediatrica Scandinavica 68 1 (1979) 57-63
34. Back S.A., Han B.H., and Luo N.L. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. Journal of Neuroscience 22 2 (2002) 455-463
35. Ness J.K., Romanko M.J., Rothstein R.P., Wood T.L., and Levison S.W. Perinatal hypoxia-ischemia induces apoptotic and excitotoxic death of periventricular white matter oligodendrocyte progenitors. Developmental Neuroscience 23 3 (2001) 203-208
36. Ness J.K., Mitchell N.E., and Wood T.L. IGF-I and NT-3 signaling pathways in developing oligodendrocytes: differential regulation and activation of receptors and the downstream effector Akt. Developmental Neuroscience 24 5 (2002) 437-445
37. Back S.A., Gan X., Li Y., Rosenberg P.A., and Volpe J.J. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. Journal of Neuroscience 18 16 (1998) 6241-6253
38. Keenan H.T., and Bratton S.L. Epidemiology and outcomes of pediatric traumatic brain injury. Developmental Neuroscience 28 4-5 (2006) 256-263
39. Tasker R.C. Changes in white matter late after severe traumatic brain injury in childhood. Developmental Neuroscience 28 4-5 (2006) 302-308
40. Bayir H., Kochanek P.M., and Kagan V.E. Oxidative stress in immature brain after traumatic brain injury. Developmental Neuroscience 28 4-5 (2006) 420-431
41. Robertson C.L., Soane L., Siegel Z.T., and Fiskum G. The potential role of mitochondria in pediatric traumatic brain injury. Developmental Neuroscience 28 4-5 (2006) 432-446
42. Thompson H.J., Lifshitz J., Marklund N., et al. Lateral fluid percussion brain injury: a 15-year review and evaluation. Journal of Neurotrauma 22 1 (2005) 42-75
43. Cortez S.C., Mcintosh T.K., and Noble L.J. Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Research 482 2 (1989) 271-282
44. Hicks R., Soares H., Smith D., and McIntosh T. Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat. Acta Neuropathologica (Berlin) 91 3 (1996) 236-246
45. Rink A., Fung K.M., Trojanowski J.Q., Lee V.M., Neugebauer E., and McIntosh T.K. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat. American Journal of Pathology 147 6 (1995) 1575-1583
46. Conti A.C., Raghupathi R., Trojanowski J.Q., and McIntosh T.K. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period. Journal of Neuroscience 18 15 (1998) 5663-5672
47. Smith D.H., Chen X.H., Pierce J.E., et al. Progressive atrophy and neuron death for one year following brain trauma in the rat. Journal of Neurotrauma 14 10 (1997) 715-727
48. Pullela R., et al. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Developmental Neuroscience 28 4-5 (2006) 396-409
49. Weller S., Gould S.J., and Valle D. Peroxisome biogenesis disorders. Annual Review of Genomics and Human Genetics 4 (2003) 165-211
50. Oglesbee D., and An overview of peroxisomal biogenesis disorders. Molecular Genetics and Metabolism 84 4 (2005) 299-301
51. Powers J.M. Demyelination in peroxisomal diseases. Journal of the Neurological Sciences 228 (2005) 206-207
52. Ginzburg L., Kacher Y., and Futerman A.H. The pathogenesis of glycosphingolipid storage disorders. Seminars in Cell & Developmental Biology 15 (2004) 417-431
53. Futerman A.H., and Van meer G. The cell biology of lysosomal storage disorders. Nature Reviews, Molecular Cell Biology 5 (2004) 554-565
54. Gallo V., and de Vellis J. Preface: white matter disorders. Mental Retardation and Developmental Disabilities Research Reviews 12 2 (2006) 83-84
55. Sen E., and Levison S.W. Astrocytes and developmental white matter disorders. Mental Retardation and Developmental Disabilities Research Reviews 12 2 (2006) 97-104
56. Van Der Knaap M.S., Pronk J.C., and Scheper G.C. Vanishing white matter disease. Lancet Neurology 5 5 (2006) 413-423
57. Kumar S., Mattan N.S., and De Vellis J. Canavan disease: a white matter disorder. Mental Retardation and Developmental Disabilities Research Reviews 12 2 (2006) 157-165
58. Gorospe J.R., and Maletkovic J. Alexander disease and megalencephalic leukoencephalopathy with subcortical cysts: leukodystrophies arising from astrocyte dysfunction. Mental Retardation and Developmental Disabilities Research Reviews 12 (2006) 113-122
59. Counsell S.J., Allsop J.M., Harrison M.C., et al. Diffusion-weighted imaging of the brain in preterm infants with focal and diffuse white matter abnormality. Pediatrics 112 1 Pt 1 (2003) 1-7
60. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., et al. Embryonic stem cell lines derived from human blastocysts. Science 282 5391 (1998) 1145-1147
61. Minguell J.J., Erices A., and Conget P. Mesenchymal stem cells. Experimental Biology and Medicine (Maywood) 226 6 (2001) 507-520
62. Bain G., Kitchens D., Yao M., Huettner J.E., and Gottlieb D.I. Embryonic stem cells express neuronal properties in vitro. Developmental Biology 168 2 (1995) 342-357
63. Brustle O., Spiro A.C., Karram K., Choudhary K., Okabe S., and McKay R.D. In vitro-generated neural precursors participate in mammalian brain development. Proceedings of the National Academy of Sciences of the United States of America 94 26 (1997) 14809-14814
64. Carpenter M.K., Inokuma M.S., Denham J., Mujtaba T., Chiu C.P., and Rao M.S. Enrichment of neurons and neural precursors from human embryonic stem cells. Experimental Neurology 172 2 (2001) 383-397
65. Reubinoff B.E., Itsykson P., Turetsky T., et al. Neural progenitors from human embryonic stem cells. Nature Biotechnology 19 12 (2001) 1134-1140
66. Flax J.D., Aurora S., Yang C., et al. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nature Biotechnology 16 11 (1998) 1033-1039
67. Brustle O., Jones K.N., Learish R.D., et al. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 285 5428 (1999) 754-756
68. Liu S., Qu Y., Stewart T.J., et al. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proceedings of the National Academy of Sciences of the United States of America 97 11 (2000) 6126-6131
69. Svendsen C.N., Clarke D.J., Rosser A.E., and Dunnett S.B. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Experimental Neurology 137 2 (1996) 376-388
70. Mcdonald J.W., Liu X.Z., Qu Y., et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nature Medicine 5 12 (1999) 1410-1412
71. Misson J.P., Austin C.P., Takahashi T., Cepko C.L., and Caviness Jr. V.S. The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cerebral Cortex 1 3 (1991) 221-229
72. Rakic P. Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. Journal of Comparative Neurology 141 3 (1971) 283-312
73. Angevine J.B., and Sidman R.L. Autoadiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature 192 (1961) 766-768
74. Gray G.E., and Sanes J.R. Migratory paths and phenotypic choices of clonally related cells in the avian optic tectum. Neuron 6 (1991) 211-225
75. Campbell K., and Gotz M. Radial glia: multi-purpose cells for vertebrate brain development. Trends in Neurosciences 25 5 (2002) 235-238
76. Hartfuss E., et al. Characterization of CNS precursor subtypes and radial glia. Developmental Biology 229 1 (2001) 15-30
77. Malatesta P., Hartfuss E., and Gotz M. Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development - Supplement 127 24 (2000) 5253-5263
78. Noctor S.C., Flint A.C., Weissman T.A., Dammerman R.S., and Kriegstein A.R. Neurons derived from radial glial cells establish radial units in neocortex. Nature 409 6821 (2001) 714-720
79. Globus J.H., and Kuhlenbeck H. Subependymal cell plate (matrix) and its relation to brain tumors of ependymal type. Journal of Neuropathology 3 (1944) 1-35
80. Thomaidou D., Mione M.C., Cavanagh J.F.R., and Parnavelas J.G. Apoptosis and its relation to the cell cycle in the developing cerebral cortex. Journal of Neuroscience 17 (1997) 1075-1085
81. Altman J. Proliferation and migration of undifferentiated precursor cells in the rat during postnatal gliogenesis. Experimental Neurology 16 3 (1966) 263-278
82. Luskin M.B. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11 (1993) 173-189
83. Levison S.W., Chuang C., Abramson B.J., and Goldman J.E. The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated. Development 119 3 (1993) 611-622
84. Levison S.W., and Goldman J.E. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron 10 2 (1993) 201-212
85. Li G., and Pleasure S.J. Morphogenesis of the dentate gyrus: what we are learning from mouse mutants. Developmental Neuroscience 27 2-4 (2005) 93-99
86. Gould E., Reeves A.J., Graziano M.S.A., and Gross C.G. Neurogenesis in the neocortex of adult primates. Science 286 5439 (1999) 548-552
87. Horner P.J., Power A.E., Kempermann G., et al. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. Journal of Neuroscience 20 6 (2000) 2218-2228
88. Zhao M., Momma S., Delfani K., et al. Evidence for neurogenesis in the adult mammalian substantia nigra. Proceedings of the National Academy Science of the United States of America 100 13 (2003) 7925-7930
89. Dayer A.G., Cleaver K.M., Abouantoun T., and Cameron H.A. New gabaergic interneurons in the adult neocortex and striatum are generated from different precursors. Journal of Cell Biology 168 3 (2005) 415-427
90. Kornack D.R., and Rakic P. Cell proliferation without neurogenesis in adult primate neocortex. Science 294 5549 (2001) 2127-2130
91. Carpenter M.K., Cui X., Hu Z.Y., et al. In vitro expansion of a multipotent population of human neural progenitor cells. Experimental Neurology 158 2 (1999) 265-278
92. Piper D.R., Mujtaba T., Keyoung H., et al. Identification and characterization of neuronal precursors and their progeny from human fetal tissue. Journal of Neuroscience Research 66 3 (2001) 356-368
93. Mayerproschel M., Kalyani A.J., Mujtaba T., and Rao M.S. Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells. Neuron 19 4 (1997) 773-785
94. Morrison S.J. Neuronal potential and lineage determination by neural stem cells. Current Opinion in Cell Biology 13 6 (2001) 666-672
95. Morrison S.J. Neuronal differentiation: proneural genes inhibit gliogenesis. Current Biology 11 9 (2001) R349-R351
96. Ostenfeld T., Joly E., Tai Y.T., et al. Regional specification of rodent and human neurospheres. Developmental Brain Research 134 1-2 (2002) 43-55
97. Rao M.S. Multipotent and restricted precursors in the central nervous system. Anatomical Record 257 4 (1999) 137-148
98. Englund U., Bjorklund A., and Wictorin K. Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain. Developmental Brain Research 134 1-2 (2002) 123-141
99. Englund U., Fricker-Gates R.A., Lundberg C., Bjorklund A., and Wictorin K. Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections. Experimental Neurology 173 1 (2002) 1-21
100. Palmer T.D., Schwartz P.H., Taupin P., Kaspar B., Stein S.A., and Gage F.H. Cell culture. Progenitor cells from human brain after death. Nature 411 6833 (2001) 42-43
101. Howell J.C., Lee W.H., Morrison P., Zhong J., Yoder M.C., and Srour E.F. Pluripotent stem cells identified in multiple murine tissues. Annals of the New York Academy of Sciences 996 (2003) 158-173
102. Meletis K., and Frisen J. Blood on the tracks: a simple twist of fate?. Trends in Neuroscience 26 6 (2003) 292-296
103. Sanchez-Ramos J.R. Neural cells derived from adult bone marrow and umbilical cord blood. Journal of Neuroscience Research 69 6 (2002) 880-893
104. Abuljadayel I.S. Induction of stem cell-like plasticity in mononuclear cells derived from unmobilised adult human peripheral blood. Current Medical Research Opinion 19 5 (2003) 355-375
105. Milhaud G. A human pluripotent stem cell in the blood of adults: towards a new cellular therapy for tissue repair. Bulletin de l'Academie Nationale de Medecine 185 3 (2001) 567-577 [discussion 577-582]
106. Zhao Y., Glesne D., and Huberman E. A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America 100 5 (2003) 2426-2431
107. Ha Y., Choi J.U., Yoon D.H., et al. Neural phenotype expression of cultured human cord blood cells in vitro. Neuroreport 12 16 (2001) 3523-3527
108. Ha Y., Lee J.E., Kim K.N., Cho Y.E., and Yoon D.H. Intermediate filament nestin expressions in human cord blood monocytes (HCMNCs). Acta Neurochirurgica (Wien) 145 6 (2003) 483-487
109. Lee O.K., Kuo T.K., Chen W.M., Lee K.D., Hsieh S.L., and Chen T.H. Isolation of multi-potent mesenchymal stem cells from umbilical cord blood. Blood 103 5 (2004) 669-675
110. Mitchell K.E., Weiss M.L., Mitchell B.M., et al. Matrix cells from Wharton's jelly form neurons and glia. Stem Cells 21 1 (2003) 50-60
111. Weiss M.L., Mitchell K.E., Hix J.E., et al. Transplantation of porcine umbilical cord matrix cells into the rat brain. Experimental Neurology 182 2 (2003) 288-299
112. Kobayashi K., Kubota T., and Aso T. Study on myofibroblast differentiation in the stromal cells of Wharton's jelly: expression and localization of alpha-smooth muscle actin. Early Human Development 51 3 (1998) 223-233
113. Jiang Y., Vaessen B., Lenvik T., Blackstad M., Reyes M., and Verfaillie C.M. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Experimental Hematology 30 8 (2002) 896-904
114. Zhao L.R., Duan W.M., Reyes M., Keene C.D., Verfaillie C.M., and Low W.C. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Experimental Neurology 174 1 (2002) 11-20
115. Lu P., Blesch A., and Tuszynski M.H. Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?. Journal of Neuroscience Research 77 2 (2004) 174-191
116. Brazelton T.R., Rossi F.M., Keshet G.I., and Blau H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290 5497 (2000) 1775-1779
117. Chu K., Kim M., Jeong S.W., Kim S.U., and Yoon B.W. Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia. Neuroscience Letters 343 2 (2003) 129-133
118. Eglitis M.A., and Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proceedings of the National Academy of Sciences of the United States of America 94 8 (1997) 4080-4085
119. Mezey E., Chandross K.J., Harta G., Maki R.A., and McKercher S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290 5497 (2000) 1779-1782
120. Le Blanc K. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 5 6 (2003) 485-489
121. Le Blanc K., Tammik C., Rosendahl K., Zetterberg E., Ringden O., et al. Hla expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Experimental Hematology 31 10 (2003) 890-896
122. Armstrong R.J., Tyers P., Jain M., et al. Transplantation of expanded neural precursor cells from the developing pig ventral mesencephalon in a rat model of Parkinson's disease. Experimental Brain Research 151 2 (2003) 204-217
123. Hori J., Ng T.F., Shatos M., Klassen H., Streilein J.W., and Young M.J. Neural progenitor cells lack immunogenicity and resist destruction as allografts. Stem Cells 21 4 (2003) 405-416
124. Kassem M., Kristiansen M., and Abdallah B.M. Mesenchymal stem cells: cell biology and potential use in therapy. Basic and Clinical Pharmacology and Toxicology 95 5 (2004) 209-214
125. Herzog E.L., Chai L., and Krause D.S. Plasticity of marrow derived stem cells. Blood 102 10 (2003) 3483-3493
126. Kicic A., Shen W.Y., Wilson A.S., Constable I.J., Robertson T., and Rakoczy P.E. Differentiation of marrow stromal cells into photoreceptors in the rat eye. Journal of Neuroscience 23 21 (2003) 7742-7749
127. Magrassi L. Differences and similarities among phenotypes of mesenchymal and neural stem cells. Haematologica 88 2 (2003) 121
128. Magrassi L., Castello S., Ciardelli L., et al. Freshly dissociated fetal neural stem/progenitor cells do not turn into blood. Molecular and Cellular Neuroscience 22 2 (2003) 179-187
129. Ortiz L.A., Gambelli F., McBride C., et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proceedings of the National Academy of Sciences of the United States of America 100 14 (2003) 8407-8411
130. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 5309 (1997) 71-74
131. Zheng T., Steindler D.A., and Laywell E.D. Transplantation of an indigenous neural stem cell population leading to hyperplasia and atypical integration. Cloning Stem Cells 4 1 (2002) 3-8
132. Mezey E., Key S., Vogelsang G., Szalayova I., Lange G.D., and Crain B. Transplanted bone marrow generates new neurons in human brains. Proceedings of the National Academy of Sciences of the United States of America 100 3 (2003) 1364-1369
133. Keene C.D., Ortiz-Gonzalez X.R., Jiang Y., Largaespada D.A., Verfaillie C.M., and Low W.C. Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell Transplant 12 3 (2003) 201-213
134. Borlongan C.V., Saporta S., Poulos S.G., Othberg A., and Sanberg P.R. Viability and survival of hNT neurons determine degree of functional recovery in grafted ischemic rats. Neuroreport 9 12 (1998) 2837-2842
135. Sinden J.D., Rashid Doubell F., Kershaw T.R., et al. Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus. Neuroscience 81 3 (1997) 599-608
136. Tourbah A., Linnington C., Bachelin C., Avellana-Adalid V., Wekerle H., and Baron-Van Evercooren A. Inflammation promotes survival and migration of the cg4 oligodendrocyte progenitors transplanted in the spinal cord of both inflammatory and demyelinated EAE rats. Journal of Neuroscience Research 50 5 (1997) 853-861
137. Franklin R.J., Bayley S.A., and Blakemore W.F. Transplanted Cg4 cells (an oligodendrocyte progenitor cell line) survive, migrate, and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord but not in normal spinal cord. Experimental Neurology 137 2 (1996) 263-276
138. Li Y., and Chopp M. Temporal profile of nestin expression after focal cerebral ischemia in adult rat. Brain Research 838 (1999) 1-10
139. Li Y., Chopp M., Powers C., and Jiang N. Apoptosis and protein expression after focal cerebral ischemia in rat. Brain Research 765 2 (1997) 301-312
140. Lindvall O., and Mckay R. Brain repair by cell replacement and regeneration. Proceedings of the National Academy of Sciences of the United States of America 100 13 (2003) 7430-7431
141. Magavi S.S., Leavitt B.R., and Macklis J.D. Induction of neurogenesis in the neocortex of adult mice. Nature 405 6789 (2000) 951-955
142. Arvidsson A., Collin T., Kirik D., Kokaia Z., and Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nature Medicine 8 9 (2002) 963-970
143. Parent J.M., Vexler Z.S., Gong C., Derugin N., and Ferriero D.M. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Annals of Neurology 52 6 (2002) 802-813
144. Ong J., Plane J.M., Parent J.M., and Silverstein F.S. Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal rat. Pediatric Research 58 3 (2005) 600-606
145. Darsalia V., Heldmann U., Lindvall O., and Kokaia Z. Stroke-induced neurogenesis in aged brain. Stroke 36 8 (2005) 1790-1795
146. Komitova M., Perfilieva E., Mattsson B., Eriksson P.S., and Johansson B.B. Enriched environment increases neural stem/progenitor cell proliferation and neurogenesis in the subventricular zone of stroke-lesioned adult rats. Stroke 36 6 (2005) 1278-1282
147. Chang A., Nishiyama A., Peterson J., Prineas J., and Trapp B.D. Ng2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. Journal of Neuroscience 20 17 (2000) 6404-6412
148. Chang A., Tourtellotte W.W., Rudick R., and Trapp B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. New England Journal of Medicine 346 3 (2002) 165-173
149. Abe K. Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury. [review] [102 Refs]. Journal of Cerebral Blood Flow & Metabolism 20 10 (2000) 1393-1408
150. Liu J., Solway K., Messing R.O., and Sharp F.R. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. Journal of Neuroscience 18 19 (1998) 7768-7778
151. Li Y., Chen J., and Chopp M. Cell proliferation and differentiation from ependymal, subependymal and choroid plexus cells in response to stroke in rats. Journal of the Neurological Sciences 193 2 (2002) 137-146
152. Parent J.M., and Lowenstein D.H. Seizure-induced neurogenesis: are more new neurons good for an adult brain?. Progress in Brain Research 135 (2002) 121-131
153. Parent J.M., Valentin V.V., and Lowenstein D.H. Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway. Journal of Neuroscience 22 8 (2002) 3174-3188
154. Teramoto T., Qiu J., Plumier J.C., and Moskowitz M.A. EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia. Journal of Clinical Investigation 111 8 (2003) 1125-1132
155. Plane J.M., Liu R., Wang T.W., Silverstein F.S., and Parent J.M. Neonatal hypoxic-ischemic injury increases forebrain subventricular zone neurogenesis in the mouse. Neurobiology Disease 16 3 (2004) 585-595
156. Tramontin A.D., Garcia-Verdugo J.M., Lim D.A., and Alvarez-Buylla A. Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment. Cerebral Cortex 13 6 (2003) 580-587
157. Fagel D.M., et al. Cortical neurogenesis enhanced by chronic perinatal hypoxia. Experimental Neurology 199 1 (2006) 77-91
158. Ganat Y., Soni S., Chacon M., Schwartz M.L., and Vaccarino F.M. Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Neuroscience 112 4 (2002) 977-991
159. Englund U., Bjorklund A., Wictorin K., Lindvall O., and Kokaia M. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proceedings of the National Academy of Sciences of the United States of America 99 26 (2002) 17089-17094
160. Zhang R.L., Zhang Z.G., Zhang L., and Chopp M. Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience 105 1 (2001) 33-41
161. Gierdalski M., Sardi S.P., Corfas G., and Juliano S.L. Endogenous neuregulin restores radial glia in a (ferret) model of cortical dysplasia. Journal of Neuroscience 25 37 (2005) 8498-8504
162. Gregg C., and Weiss S. CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain. Development 132 3 (2005) 565-578
163. Nakatomi H., Kuriu T., Okabe S., et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110 4 (2002) 429-441
164. Gieselmann V., Matzner U., Klein D., et al. Gene therapy: prospects for glycolipid storage diseases. Philosophical Transactions of the Royal of Society London Series B. Biological Sciences 358 1433 (2003) 921-925
165. Givogri M.I., Galbiati F., Fasano S., et al. Oligodendroglial progenitor cell therapy limits central neurological deficits in mice with metachromatic leukodystrophy. Journal of Neuroscience 26 12 (2006) 3109-3119
166. Meng X.L., Shen J.S., Ohashi T., Maeda H., Kim S.U., and Eto Y. Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse. Journal of Neuroscience Research 74 2 (2003) 266-277
167. Svendsen C.N., and Caldwell M.A. Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation. [Review] [96 Refs]. Progress in Brain Research 127 (2000) 13-34