Perinatal hypoxia-ischemia induces apoptotic and excitotoxic death of periventricular white matter oligodendrocyte progenitors

Developmental Neuroscience

Volumn 23, Issue 3, 2001, Pages 203-208

  Ness, Jennifer K ^a   Romanko, Michael J ^a   Rothstein, Raymond P ^a   Wood, Teresa L ^a   Levison, Steven W ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspases; Cell death; Cerebral palsy; Neuroglia; Oligodendrocytes; Rats; Stroke

Indexed keywords

CASPASE 3; DNA FRAGMENT; GLUTAMIC ACID; OXYGEN RADICAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BRAIN INJURY; CELL HYPOXIA; CELL MATURATION; CEREBRAL PALSY; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME LOCALIZATION; FEMALE; HYBRID CELL; ISCHEMIA; NERVE CELL NECROSIS; NEWBORN; NEWBORN MORTALITY; NONHUMAN; OLIGODENDROGLIA; PERINATAL ASPHYXIA; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; RAT; STEM CELL; WHITE MATTER;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CEREBRAL PALSY; CEREBRAL VENTRICLES; FEMALE; HYPOXIA-ISCHEMIA, BRAIN; MICROSCOPY, ELECTRON; NEUROTOXINS; OLIGODENDROGLIA; PREGNANCY; RATS; RATS, WISTAR; STEM CELLS;

EID: 0035742015     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000046144     Document Type: Conference Paper

References (19)

1. Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury
2. Brain injury in the premature infant - From pathogenesis to prevention
3. Cellular and molecular pathogenesis of periventricular white matter injury
4. White matter injury in the pre-term infant: An important determination of abnormal neurodevelopmental outcome
5. Maturation-dependant vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion
6. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors mediate excitotoxicity in the oligodendroglial lineage
7. Multiple classes of the oligodendrocyte lineage are highly vulnerable to excitotoxicity
8. NBQX attenuates excitotoxic injury in developing white matter
9. Preferential injury of oligodendroblasts by a short hypoxic-ischemic insult
10. Subcellular distribution of calcium and ultra-structural changes after cerebral hypoxia-ischemia in immature rats
11. The influence of immaturity on hypoxic-ischemic brain damage in the rat
12. Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature rat brain
13. Selective apoptosis within the rat subependymal zone: A plausible mechanism for determining which lineages develop from neural stem cells
14. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan
15. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
16. Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transient forebrain ischemia in the adult gerbil
17. Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: A light microscopic study
18. Hypoxic/ischemic insult alters ferritin expression and myelination in neonatal rat brains