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Volumn 61, Issue 5, 2007, Pages 277-284

Inhibition of phosphatidylinositol 3-kinase causes cell death in rat osteoblasts through inactivation of Akt

Author keywords

LY294002; Osteoblasts; PI3 kinase Akt pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B;

EID: 34249986378     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2007.02.014     Document Type: Article
Times cited : (15)

References (31)
  • 1
    • 0036632368 scopus 로고    scopus 로고
    • The phsophatidylinositol 3-kinase-Akt pathway in human cancer
    • Vivanco I., and Sawyers C.L. The phsophatidylinositol 3-kinase-Akt pathway in human cancer. Nat Rev Cancer 2 (2002) 489-501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 2
    • 0033594480 scopus 로고    scopus 로고
    • PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
    • Balendran A., Casamayor A., Deak M., Paterson A., Gaffney P., Currie R., et al. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol 9 8 (1999) 393-404
    • (1999) Curr Biol , vol.9 , Issue.8 , pp. 393-404
    • Balendran, A.1    Casamayor, A.2    Deak, M.3    Paterson, A.4    Gaffney, P.5    Currie, R.6
  • 3
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PDK1 connection: more than just a road to PKB
    • Vanhaesebroeck B., and Alessi D.R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346 (2000) 561-576
    • (2000) Biochem J , vol.346 , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 5
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signaling
    • Romashkova J.A., and Makarov S.S. NF-kappaB is a target of AKT in anti-apoptotic PDGF signaling. Nature 401 (1999) 86-90
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 6
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
    • Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96 (1999) 857-868
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 7
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couple survival signals to the cell-intrinsic death machinery
    • Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., et al. Akt phosphorylation of BAD couple survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6
  • 9
    • 0033628571 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation
    • Krasilnikov M.A. Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry (Mosc) 65 (2000) 59-67
    • (2000) Biochemistry (Mosc) , vol.65 , pp. 59-67
    • Krasilnikov, M.A.1
  • 10
    • 27344455191 scopus 로고    scopus 로고
    • Co-induction of cell death and survival pathways by phosphoinositide 3-kinase
    • Lee S.B., Hong S.H., Kim H., and Um H.D. Co-induction of cell death and survival pathways by phosphoinositide 3-kinase. Life Sci 78 1 (2005) 91-98
    • (2005) Life Sci , vol.78 , Issue.1 , pp. 91-98
    • Lee, S.B.1    Hong, S.H.2    Kim, H.3    Um, H.D.4
  • 11
    • 14844329891 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3 kinases on cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    • Gottschalk A.R., Doan A., Nakamura J.L., Hass-Kogan D.A., and Stokoe D. Inhibition of phosphatidylinositol-3 kinases on cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism. Int J Radiat Oncol Biol Phys 61 4 (2005) 1183-1188
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , Issue.4 , pp. 1183-1188
    • Gottschalk, A.R.1    Doan, A.2    Nakamura, J.L.3    Hass-Kogan, D.A.4    Stokoe, D.5
  • 12
    • 0034647674 scopus 로고    scopus 로고
    • Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors
    • Borgatti P., Martelli A.M., Bellacosa A., Casto R., Massari L., Capitani S., et al. Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors. FEBS Lett 477 (2000) 27-32
    • (2000) FEBS Lett , vol.477 , pp. 27-32
    • Borgatti, P.1    Martelli, A.M.2    Bellacosa, A.3    Casto, R.4    Massari, L.5    Capitani, S.6
  • 13
  • 14
    • 16544387699 scopus 로고    scopus 로고
    • Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts
    • Kang H.Y., Cho C.L., Huang K.L., Wang J.C., Hu Y.C., Lin H.K., et al. Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts. J Bone Miner Res 19 (2004) 1181-1190
    • (2004) J Bone Miner Res , vol.19 , pp. 1181-1190
    • Kang, H.Y.1    Cho, C.L.2    Huang, K.L.3    Wang, J.C.4    Hu, Y.C.5    Lin, H.K.6
  • 15
    • 21244494046 scopus 로고    scopus 로고
    • Possible involvement of phosphatidylinositol 3-kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts
    • Noda T., Tokuda H., Yoshida M., Yasuda E., Hanai Y., Takai S., et al. Possible involvement of phosphatidylinositol 3-kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts. Horm Metab Res 37 (2005) 270-274
    • (2005) Horm Metab Res , vol.37 , pp. 270-274
    • Noda, T.1    Tokuda, H.2    Yoshida, M.3    Yasuda, E.4    Hanai, Y.5    Takai, S.6
  • 17
    • 0034012322 scopus 로고    scopus 로고
    • Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
    • Bursch W., Hochegger K., Torok L., Marian B., Ellinger A., and Hermann R.S. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 113 7 (2000) 1189-1198
    • (2000) J Cell Sci , vol.113 , Issue.7 , pp. 1189-1198
    • Bursch, W.1    Hochegger, K.2    Torok, L.3    Marian, B.4    Ellinger, A.5    Hermann, R.S.6
  • 18
    • 0642345196 scopus 로고    scopus 로고
    • Cytoskeletal reorganization during process of apoptosis induced by cytostatic drugs in K-562 and HL-60 leukemia cell lines
    • Grzanka A., Grzanka D., and Orlikowska M. Cytoskeletal reorganization during process of apoptosis induced by cytostatic drugs in K-562 and HL-60 leukemia cell lines. Biochem Pharmacol 66 8 (2003) 1611-1617
    • (2003) Biochem Pharmacol , vol.66 , Issue.8 , pp. 1611-1617
    • Grzanka, A.1    Grzanka, D.2    Orlikowska, M.3
  • 19
    • 0030957458 scopus 로고    scopus 로고
    • Actin is cleaved during constitutive apoptosis
    • Brown S.B., Bailey K., and Savill J. Actin is cleaved during constitutive apoptosis. J Biochem 323 (1997) 233-237
    • (1997) J Biochem , vol.323 , pp. 233-237
    • Brown, S.B.1    Bailey, K.2    Savill, J.3
  • 20
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos C.J., Matter W.F., Hui K.Y., and Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269 (1994) 5241-5248
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 21
    • 0036713283 scopus 로고    scopus 로고
    • Apoptosis of rat osteoblasts in process of calcification in vitro
    • Gu Q., Zhu H.M., and Zhang X.J. Apoptosis of rat osteoblasts in process of calcification in vitro. Acta Pharmacol Sin 23 9 (2002) 808-812
    • (2002) Acta Pharmacol Sin , vol.23 , Issue.9 , pp. 808-812
    • Gu, Q.1    Zhu, H.M.2    Zhang, X.J.3
  • 23
    • 0032540289 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms
    • Harada-Shiba M., Kinoshita M., Kamido H., and Shimokado K. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. J Biol Chem 273 (1998) 9681-9687
    • (1998) J Biol Chem , vol.273 , pp. 9681-9687
    • Harada-Shiba, M.1    Kinoshita, M.2    Kamido, H.3    Shimokado, K.4
  • 24
    • 1342306723 scopus 로고    scopus 로고
    • Mitochondrial involvement in RP-1 mediated apoptosis in U87 cells
    • Agrawala P.K., Mittal A., Bala M., and Goel H.C. Mitochondrial involvement in RP-1 mediated apoptosis in U87 cells. Biomed Pharmacother 58 (2004) 129-135
    • (2004) Biomed Pharmacother , vol.58 , pp. 129-135
    • Agrawala, P.K.1    Mittal, A.2    Bala, M.3    Goel, H.C.4
  • 25
    • 3042801429 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway
    • Uddin S., Hussain A., Al-Hussein K., Platanias L.C., and Bhatia K.G. Inhibition of phosphatidylinositol 3-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway. Biochem Biophys Res Commun 320 (2004) 932-938
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 932-938
    • Uddin, S.1    Hussain, A.2    Al-Hussein, K.3    Platanias, L.C.4    Bhatia, K.G.5
  • 26
    • 0037428872 scopus 로고    scopus 로고
    • LY294002, an inhibitor of phosphatidylinositol-3-kinase, causes preferential induction of apoptosis in human multidrug resistant cells
    • Nicholson K.M., Quinn D.M., Kellett G.L., and Warr J.R. LY294002, an inhibitor of phosphatidylinositol-3-kinase, causes preferential induction of apoptosis in human multidrug resistant cells. Cancer Lett 190 1 (2003) 31-36
    • (2003) Cancer Lett , vol.190 , Issue.1 , pp. 31-36
    • Nicholson, K.M.1    Quinn, D.M.2    Kellett, G.L.3    Warr, J.R.4
  • 27
    • 0038718799 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3′-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac
    • Yip-Schneider M.T., Wiesenauer C.A., and Schmidt C.M. Inhibition of the phosphatidylinositol 3′-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac. J Gastrointest Surg 7 3 (2003) 354-363
    • (2003) J Gastrointest Surg , vol.7 , Issue.3 , pp. 354-363
    • Yip-Schneider, M.T.1    Wiesenauer, C.A.2    Schmidt, C.M.3
  • 29
    • 0033844188 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase translocation to the nucleus of osteoblast-like MC3T3-E1cells in response to insulin-like growth factor 1 and platelet-derived growth factor but not to the proapoptotic cytokine tumor necrosis factor
    • Martelli A.M., Borgatti P., Bortul R., Marmiroli L., Capitani S., and Neri L.M. Phosphatidylinositol 3-kinase translocation to the nucleus of osteoblast-like MC3T3-E1cells in response to insulin-like growth factor 1 and platelet-derived growth factor but not to the proapoptotic cytokine tumor necrosis factor. J Bone Miner Res 15 (2000) 1716-1730
    • (2000) J Bone Miner Res , vol.15 , pp. 1716-1730
    • Martelli, A.M.1    Borgatti, P.2    Bortul, R.3    Marmiroli, L.4    Capitani, S.5    Neri, L.M.6
  • 30
    • 0037057801 scopus 로고    scopus 로고
    • The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system
    • Neri L.M., Borgatti P., Capitani S., and Martelli A.M. The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim Biophys Acta 1584 (2002) 73-80
    • (2002) Biochim Biophys Acta , vol.1584 , pp. 73-80
    • Neri, L.M.1    Borgatti, P.2    Capitani, S.3    Martelli, A.M.4
  • 31
    • 20344386701 scopus 로고    scopus 로고
    • Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B.
    • Fujita H., Utsumi T., Muranaka S., Ogino T., Yano H., Akiyama J., et al. Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B. Biochem Pharmacol 69 12 (2005) 1773-1784
    • (2005) Biochem Pharmacol , vol.69 , Issue.12 , pp. 1773-1784
    • Fujita, H.1    Utsumi, T.2    Muranaka, S.3    Ogino, T.4    Yano, H.5    Akiyama, J.6


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