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Volumn 316, Issue 5828, 2007, Pages 1148-1153

Forces and bond dynamics in cell adhesion

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; BIOCHEMISTRY; MOLECULAR ANALYSIS; SIGNALING;

EID: 34249936024     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1137592     Document Type: Review
Times cited : (443)

References (54)
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    • o reported for spontaneous dissociation of ligand/receptor bonds range from a fraction of a second to 100 s or more.
    • o reported for spontaneous dissociation of ligand/receptor bonds range from a fraction of a second to 100 s or more.
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    • -10 g wt).
    • -10 g wt).
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    • β), suggesting that the energy landscape changes to increase the length gained in the direction of force when the bond breaks.
    • β), suggesting that the energy landscape changes to increase the length gained in the direction of force when the bond breaks.
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    • Advanced computational methods like the steered molecular dynamics described in the companion review by Sotomayor and Schulten (36) provide valuable tools for investigating how variations in chemical structure affect activation energy barriers and pathways governing bond strength.
    • Advanced computational methods like the "steered molecular dynamics" described in the companion review by Sotomayor and Schulten (36) provide valuable tools for investigating how variations in chemical structure affect activation energy barriers and pathways governing bond strength.
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    • f (pN/nm) to report the force history f(t). Bond events are identified by the cycles showing periods of probe stretch ending in precipitous recoil, as sketched in Fig. 2A.
    • f (pN/nm) to report the force history f(t). Bond events are identified by the cycles showing periods of probe stretch ending in precipitous recoil, as sketched in Fig. 2A.
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    • rf). It is important to note that different cell types possess very different levels of interfacial stiffness and that these levels often change with cell activation or spreading on a stiffer substrate.
    • rf). It is important to note that different cell types possess very different levels of interfacial stiffness and that these levels often change with cell activation or spreading on a stiffer substrate.
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    • As lipid material flows onto a tether, bilayer-spanning proteins (especially those that interact with the cytoskeleton) are expected to remain behind in the cell membrane. However, the acylated proteins bound weakly to the bilayer could build up at the base of the tether, causing some to be expelled from the surface when approaching the tether-cell junction
    • As lipid material flows onto a tether, bilayer-spanning proteins (especially those that interact with the cytoskeleton) are expected to remain behind in the cell membrane. However, the acylated proteins bound weakly to the bilayer could build up at the base of the tether, causing some to be expelled from the surface when approaching the tether-cell junction.
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    • Supported by grants from the National Institutes of Health
    • Supported by grants from the National Institutes of Health.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.