Selectins: Lectins that initiate cell adhesion under flow

Current Opinion in Cell Biology

Volumn 14, Issue 5, 2002, Pages 581-586

  McEver, Rodger P ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LECTIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; RAF PROTEIN; RAS PROTEIN; SELECTIN;

ANIMAL CELL; CELL ADHESION; CELL SURFACE; ENDOTHELIUM CELL; LEUKOCYTE ADHERENCE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW;

ANIMALIA;

EID: 0036775765     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(02)00367-8     Document Type: Review

References (50)

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3. x bound to P- and E-selectin and of an amino-terminal glycosulfopeptide of PSGL-1 bound to P-selectin.
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19. x on extended core-1 O-glycans, which bind L-selectin.
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36. Ramachandran V., Yago T., Epperson T.K., Kobzdej M.M.A., Nollert M.U., Cummings R.D., Zhu C., McEver R.P. Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow. Proc Natl Acad Sci USA. 98:2001;10166-10171. Using dimeric and monomeric forms of P-selectin and PSGL-1, the authors show that dimerization of these molecules strengthens tethers of rolling cells. The data indicate that transient adhesive tethers may have more than one bond, suggesting that the mechanical strengths of single selectin-ligand bonds may be less than the initial estimates.
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