Assessing the reliability of PBPK models using data from methyl chloride-exposed, non-conjugating human subjects

Archives of Toxicology

Volumn 75, Issue 4, 2001, Pages 189-199

  Jonsson, Fredrik ^a   Bois, Frédéric Y ^b   Johanson, Gunnar ^a,c  

^a NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^b INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Intra individual variability; Methyl chloride; Non conjugators; PBPK

Indexed keywords

METHYL CHLORIDE;

ADULT; ARTICLE; BAYES THEOREM; DRUG CONJUGATION; DRUG ELIMINATION; ENVIRONMENTAL EXPOSURE; EXHALATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MODEL; NORMAL HUMAN; PRIORITY JOURNAL; RELIABILITY; SYSTEM ANALYSIS; TOXICOKINETICS;

ADULT; BAYES THEOREM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; METHYL CHLORIDE; MIDDLE AGED; MODELS, BIOLOGICAL; MONTE CARLO METHOD; OBSERVER VARIATION; PHARMACOKINETICS; RISK ASSESSMENT; SOLVENTS; SWEDEN;

EID: 0034992283     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040100221     Document Type: Article

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